Embodiments described herein relate to methods and apparatus for extracting a fluid from a container. In some aspects, an extraction member can comprise a first coupling portion configured to removably couple the extraction member to a medicament container containing a medicament, a puncture member defining a fluidic channel and configured to pierce the septum seal to establish fluidic communication between the medicament container and the medicament injector, and a seal disposed between the first coupling portion and the second coupling portion, and defining an opening through which the puncture member is disposed and extends therefrom towards the first coupling portion thereby defining a medicament collection area circumferentially surrounding a portion of the puncture member between the seal and a distal end of the puncture member.

In certain embodiments, a vial adaptor comprises a housing configured to couple the adaptor with a vial, an access channel, a regulator channel, and a regulator assembly. The access channel is configured to facilitate withdrawal of fluid from the vial when the adaptor is coupled to the vial. The regulator channel is configured to facilitate a flow of a regulating fluid from the regulator assembly to compensate for changes in volume of a medical fluid in the vial. In some embodiments, the regulator assembly includes a flexible member configured to expand and contract in accordance with changes in the volume of the medical fluid in the vial. In some embodiments, the flexible member is substantially free to expand and contract. In some embodiments, the flexible member is not partly or completely located in a rigid enclosure.

The invention relates to a fluid valve and fluid connection system, comprising a casing having a chamber with a first internal connection element and a first external connection element; comprising a first movable valve element in the chamber; and comprising an actuating element which has a fluid communication system with a second internal connection element and a second external connection element; wherein the first internal connection element cooperates with the second internal connection element and the valve element to establish or block a fluid connection between the first and second external connection elements.

A system includes a vial access device including a vial access housing having a wall defining an elongate opening between an opening proximal end and an opening distal end, the vial access housing including a spike and a vial connection element attachable to a first vial defining a first vial size to secure the vial access device to the first vial, and an adapter movable within the elongate opening of the vial access housing. The adapter is transitionable between a first position where the adapter is adjacent the opening distal end of the vial access housing and the adapter is attachable to a second vial defining a second vial size and a second position where the adapter is adjacent the opening proximal end of the vial access housing and the vial connection element of the vial access device is attachable to the first vial.

A fluid transfer device can include a first attachment portion configured to engage a first port of a source container and a second attachment portion configured to engage a second port of an intermediate container. The first attachment portion can include a first projection defining a first fluid passage and the second attachment portion can include a second projection defining a second fluid passage. The fluid transfer device can further include a selector portion for selectively transitioning the fluid transfer device from a first configuration in which a flow path between the first and second fluid passages is closed to a second configuration in which the flow path between the first and second fluid passages is open. The fluid transfer device can further include a limiter configured to inhibit the selector portion from selectively transitioning the fluid transfer device from the first configuration to the second configuration.

A syringe adaptor includes a body, shaped to define a body lumen, a syringe fitting at a proximal end of the body, configured to connect to a distal end of a syringe, a needle extending distally from the syringe fitting into the body lumen, a septum housing, and an elastomeric septum mounted inside the septum housing. The septum includes a proximal face, shaped to define an aperture having an aperture diameter, and a distal face. The septum is shaped to define a cavity, joined to the aperture, having a cavity diameter that is larger than the aperture diameter. The septum housing is configured to slide proximally within the body lumen such that a distal end of the needle contained in the cavity passes through the distal face of the septum. Other embodiments are also described.

A method of preparing liquid medication doses using an automated dosing device may include securing a vial within a vial holder. The vial includes a liquid medicament. An empty syringe is secured within a syringe holder with a plunger of the syringe being secured by a plunger gripper and a luer lock of the syringe within a luer lock gripper. The syringe holder and the vial holder are moved closer together to insert a needle of the syringe through a septum of the vial while longitudinal axes of the syringe and the vial are at a downward angle and while the vial holder is lower than the syringe holder. The syringe holder and the vial holder are rotated to vertically align the longitudinal axes with the vial holder above the syringe holder. The plunger gripper is pulled away from the luer lock gripper to transfer liquid medicament into the syringe.

A drug transfer adapter includes a body having a first end and a second end positioned opposite the first end, a transfer spike extending from the body and defining an opening, with the transfer spike configured to pierce a closure of a container, a connector extending from the body, and a securing member extending from the body. The securing member has a first side and a second side positioned opposite the first side, with the first side of the securing member including an adhesive surface configured to secure the body to a container.

A reconstitution device comprising a cartridge (212) containing a first substance, the cartridge having a plunger (238) at one end and a piercable septum (222) at a second end, a vial (218) containing a second substance, the vial having a piercable septum (224), a housing (210), a cartridge needle hub (226), the cartridge needle hub (226) having a needle (228) protruding therefrom, a vial needle hub (229), the vial needle hub having a needle (222) protruding therefrom, the vial needle hub (229) and the cartridge needle hub (226) being releasably securable together, cartridge latches (240) holding the cartridge needle hub (226) within the housing, vial needle hub latches (231) extending to engage the housing, and a plunger rod (232), the plunger rod having an inner portion (234) engageable with the plunger (238) of the cartridge, the plunger rod (232) having an outer portion (236) which is adapted to engage the vial needle hub latches (240) to release the vial needle hub (229) from engagement with the cartridge needle hub (226), whereby the vial (218) and the vial needle hub (229) may be released from the housing.

A system for the closed transfer of fluids that provides substantially leak-proof sealing and pressure equalization during engagement of a cannula with a vial, during transfer of a substance from a vial chamber to a barrel chamber via the cannula, and during disengagement of the cannula from the vial is disclosed. The leak-proof sealing of the system substantially prevents leakage of both air and liquid during use of the system. The system of the present disclosure also permits pressure equalization between a vial and the system when the system is attached to the vial. The system is compatible with a needle and syringe assembly for accessing a medication contained within a vial for administering the medication to a patient.