A system for closed transfer of fluids includes a syringe adapter including a cannula having a first end and a second end with the second end positioned within the housing, and a seal arrangement positioned within the housing and movable within the housing with the seal arrangement including a membrane. The system including a second component including a membrane and a locking mechanism. The second component configured to be received by the syringe adapter such that the membrane of the seal arrangement engages the membrane of the second component. The locking mechanism including a biasing member and an engagement member positioned on the biasing member, with the engagement member configured to engage a portion of the housing of the syringe adapter to secure the second component to the syringe adapter when the second component is received by the syringe adapter.

A vial adapter includes a body having a component connection interface and a vial connection interface, with the component connection interface configured to engage a connection interface of a mating component, a pressure equalization assembly including a chamber configured to expand from a first volume to a second volume larger than the first volume, and a piercing member having a first end connected to the body and a second end positioned opposite the first end. The second end of the piercing member includes a piercing point configured to pierce a closure of a vial, with the first and second fluid ports extending from a position intermediate the first and second ends of the piercing member to the second end of the piercing member. The first and second fluid ports and a portion of the piercing member define a V-shaped profile at the second end of the piercing member.

A robotic system and method are provided for transfer of fluid between a container accessible via a container-septum and a fluid transfer assembly accessible via a fluid transfer connector septum. The robotic system includes a controller and a manipulator controllable by the controller to manipulate at least one of the container and the fluid transfer assembly. The controller is configured to operate the manipulator to secure contact between the container-septum and the fluid transfer connector septum during at least a portion of the transfer of the fluid.

A syringe of a syringe assembly is provided with a body portion capable of being filled with a drug solution and a female port nozzle portion which extends from a distal end of the body portion and includes a communication port on a proximal end of the female port nozzle. The body portion includes a distal end wall surface and a side wall surface to which a liquid lubricant is applied. The distal end wall surface includes a concave portion arranged radially outside an inner edge portion adjacent to the communication port and concave in a distal end direction more than at least a part of the inner edge portion, and the concave portion is arranged to fully surround the communication port and may store the liquid lubricant.

A system including an adapter for sequential engagement with a cartridge containing a first substance and a vial containing a second substance is disclosed. The adapter is configured to first engage with the vial and subsequently engage with the cartridge such that the cartridge is in fluid communication with the vial via the adapter. The system includes a latch member engageable with a portion of the cartridge. A plunger rod includes a protrusion and is adapted to communicate with the latch member, the plunger rod being transitionable from a disengaged position, in which the protrusion of the plunger rod is disengaged from the latch member and the latch member is locked to the cartridge, to an engaged position, in which the protrusion is engaged with the latch member and the latch member is unlocked from the cartridge and locked to the plunger rod.

The present disclosure relates to medical vials pre-attached with a vial adapter assembly for the transfer of gases/liquids/fluid or other substances to/from medical vials.

An adapter (14) for transferring a substance from a first container (10) into a second container, having a circumferential wall (47) suitable for housing the first container, along which a cannula body (64) extends and by which said cannula body is coaxially surrounded at least in part, said adapter also comprising a hollow cylindrical section (26) connected to the cannula body and connectable to the second container. The cannula body extends with the longitudinal axis thereof perpendicular to one side of a wall (24) running transversely with respect to the circumferential wall and the hollow cylindrical section extends with the longitudinal axis perpendicular to the other side of the wall. The adapter (14) has a cup-shaped outer body (18) having an outer circumferential wall (32) and the wall (24), running transversely to the longitudinal axis of the outer body, which has an insert (46) having the circumferential wall (47).

Described are improvements to components of fluid transfer apparatuses comprising a first component, e.g. a syringe, a connector component configured to connect between the first component and an adapter component that is configured to allow connection of the connector component to a second component of the drug transfer apparatus, e.g. to a drug vial. The improvements include inter alia changes to the sealing elements that seal the proximal end of the syringe, redesign of a septum holder inside the connector component and corresponding redesign of the housing of the connector component; changes to the structure of the end of the connector component that connects to the first component to allow the first component to swivel relative to the connector component; and changes to the design of the adapter component to a second component of the drug transfer apparatus to allow it to mate with the redesigned housing of the connector component.

An assembly for adding a medication or like substance to a liquid solution in a flexible bag (10) is provided. The flexible bag (10) contains a liquid solution, such as dialysate. An adapter (14) extends from the flexible bag (10) and includes a skirt (20) having an array of resilient sections (22) for engaging and snapping onto a neck finish (106) of a separate vial (100) containing a medication or like substance. A locking device (16) is adapted to be secured about the skirt (20) in a locking position that prevents outward movement of the array of resilient sections (22) and thereby prevents disengagement of the vial (100) from the adapter (14). A method of transferring the liquid solution from the bag (10) to the vial (100), mixing the medication with the liquid solution, and returning the mixture to the bag (10) is also provided.

A device for training users in a proper mixing of pharmaceutical components, or for aiding in the mixing, or for performing the mixing, and administration of pharmaceutical components is disclosed. The device comprises a housing for receiving a pharmaceutical delivery device containing the pharmaceutical components. There is also a microcontroller disposed in the housing and a motion/orientation detection device disposed within or on the housing and in communication with the microcontroller. A method for use of the device is also disclosed, along with a substance for use as one of the pharmaceutical components.