Fluid transfer systems are disclosed that can be configured to transfer precise amounts of fluid from a source container to a target container. The fluid transfer system can have multiple fluid transfer stations for transferring fluids into multiple target containers or for combining different types of fluids into a single target container to form a mixture. The fluid transfer system can include a pump and a destination sensor, such as a weight sensor. The fluid transfer system can be configured to flush remaining fluid out of a connector to reduce waste, using air or a flushing fluid.

Dual vial adapter assemblages similar to U.S. Pat. No. 6,558,365 to Zinger et al. and U.S. Pat. No. 8,752,598 to Denenburg et al. and including a quick release drug vial adapter with an upright finger grip extension pair oppositely for manually urging inwards towards one another for releasing same from a drug vial. The quick release drug vial adapter ensures correct usage of a dual vial adapter assemblage by preventing immediate removal of a drug vial adapter from a drug vial after forming a liquid drug therein thereby assisting a healthcare provider to follow an administration protocol requiring an initial aspiration of some liquid drug for immediate administration purposes to a patient prior to subsequent infusion of the liquid drug remainder.

A bag having two accesses, an inlet and an outlet, both containing closing devices for releasing or stopping the flow of a liquid that flows into or out of the bag. The inlet has a filtering element for retaining particles possibly produced by the coring phenomenon which can occur when the spike of the inlet ruptures the plug of the bottle. Also provided is a safety device used for permanently attaching the bottle to the inlet.

A fluid transfer system includes packaging having a body with a sidewall extending between an open top end and a bottom end and defining an interior cavity, and at least one protrusion extending radially inward from the sidewall into the interior cavity. The system also includes a fluid transfer device including an inner member and an outer member surrounding at least a portion of the inner member. The inner member having a first position where the inner member is configured to rotate freely relative to the outer member and a second position where rotation of the inner member relative to the outer member is restricted in a first rotational direction. The fluid transfer device also including a locking arrangement configured for cooperating with the at least one protrusion to prevent rotation of the inner member relative to the outer member upon an application of a compressive force on the packaging.

In certain embodiments, a vial adaptor comprises a housing configured to couple the adaptor with a vial, an access channel, a regulator channel, and a regulator assembly. The access channel is configured to facilitate withdrawal of fluid from the vial when the adaptor is coupled to the vial. The regulator channel is configured to facilitate a flow of a regulating fluid from the regulator assembly to compensate for changes in volume of a medical fluid in the vial. In some embodiments, the regulator assembly includes a flexible member configured to expand and contract in accordance with changes in the volume of the medical fluid in the vial. In some embodiments, the flexible member is substantially free to expand and contract. In some embodiments, the flexible member is not partly or completely located in a rigid enclosure.

A fluid transfer device can include a first attachment portion configured to engage a first port of a source container and a second attachment portion configured to engage a second port of an intermediate container. The first attachment portion can include a first projection defining a first fluid passage and the second attachment portion can include a second projection defining a second fluid passage. The fluid transfer device can further include a selector portion for selectively transitioning the fluid transfer device from a first configuration in which a flow path between the first and second fluid passages is closed to a second configuration in which the flow path between the first and second fluid passages is open. The fluid transfer device can further include a limiter configured to inhibit the selector portion from selectively transitioning the fluid transfer device from the first configuration to the second configuration.

Provided is a pressure equalizing device for facilitating drug reconstitution in a closed system. The pressure equalizing device includes a container for attachment to a receptacle, to permit pressure equalization between the container and the receptacle. The container includes a first chamber and a second chamber. The device further includes a vent channel extending between the first chamber and a distal opening of the vent channel. In accordance with the invention, when the receptacle is connected to the pressure equalizing device, the vent channel establishes direct fluid communication between the first chamber and the receptacle. Additionally, a longitudinal axis of the pressure equalizing device is configured to be aligned with or parallel to a longitudinal axis of the receptacle when the pressure equalizing device is attached to the receptacle.

A fluidic group (21) couplable to a first container (24) adapted to contain a drug and a second container (22) adapted to contain an ingredient, comprising: a syringe (154) comprising a movable piston (150) defining a chamber (162a) having a variable volume; a first (171, 172) and a second (25) coupling group selectively fixable to the second (22) and, respectively, to the first (24) container; a forking element (166) having a first (166′), a second (166″) and a third (166′″) inlet in fluid communication with each other and, respectively, with the first coupling group (171, 172), with the second coupling group (25) and with the chamber (162a); a first one-way valve (168) interposed between the first coupling group (171, 172) and the forking element (166) and controllable to allow the passage of the ingredient from the second container (22) to the chamber (162a); and a second one-way valve (176) interposed between the second coupling group (25) and the forking element (166) and controllable to allow the passage of the ingredient from the chamber (162a) to the first container (24).

Liquid drug transfer devices with universal drug vial adapters for use with a drug vial of a small drug vial and a large drug vial. Some universal drug vial adapters employ the same generally opposite upright flex members for clamping a small drug vial and a large drug vial. Other universal drug vial adapters include a set of minor flex members for clamping a small drug vial and a set of major flex members encircling the set of minor flex members for clamping a large drug vial whereupon the large drug vial underlies the set of minor flex members. Liquid drug transfer devices with a universal injection port connector for attachment on an injection port of an infusion bag.

A drug container closure for mounting on an open-topped drug container to form a ready-to-use drug reconstitution assemblage for use with a needleless syringe. The drug container closure includes a drug container stopper for sealing the drug container and a fluid transfer member with an integral needleless syringe connector and a puncturing cannula. The fluid transfer member is manually disposed along a diametric inverted L-shaped track pair from an initial non-puncturing position to a puncturing position. The inverted L-shaped track pair includes one-way snap members to prevent a user returning the fluid transfer member to an earlier position and indicating progress of the user activation.