A vial adaptor comprises first and second housings coupled to each other, a sheath enclosing the first and second housings, and a spike disposed in the first and second housings. The first and second housings form a first chamber therein. The sheath and the first and second housings form therebetween a second chamber in air communication with the first chamber. The second housing is slidable relative to the first housing to cause the spike piercing through a front stopper to establish air and fluid communication with a vial attached to the vial adaptor, meanwhile to vary the volume of the first chamber and press the air into the second chamber. Upon a fluid being drawn from the vial, the air in the first and second chambers enters the vial to compensate the pressure reduction caused by the fluid drawn out to prevent fluid spillage or aerosolizing from the vial.

The present invention relates to a device for vacuum and vent tube stoppering a medical container. The device includes a main body defining an internal volume that has a first variable pressure chamber configured to be connected to a vacuum pump, the main body being configured to receive the proximal end of a medical container so that said medical container is in communication with the first variable pressure chamber. A vent device including a vent tube is moveable inside the internal volume of the main body along a longitudinal axis between a proximal rest position and a distal operative position. A piston rod is moveable inside the internal volume of the vent tube along the longitudinal axis between a proximal rest position and a distal operative position. A container holder system is provided in the main body, in communication with the first variable pressure chamber.

Connection equipment includes an equipment connector comprising a first connecting section, a first liquid flow path that communicates with a equipment, and a first valve that is to open and close the first liquid flow path, a container connector comprising a second connecting section, a second liquid flow path that communicates with the container, and a second valve that is to open and close the second liquid flow path, and a lock mechanism that locks the equipment connector and the container connector in a state where the first liquid flow path is in communication with the second liquid flow path, and that unlocks the connectors in a state where the first valve and the second valve are closed.

The invention relates to a fluid transfer system (1) for transferring medical substances or drugs. It further relates to components and parts of such a transfer system (1), in particular its connecting components (2, 6) and the parts equipped with such connecting components (2, 6), such as syringes (4), containers (vials) (8) or application systems. According to the invention, a screw connection of the connecting components (2, 6) to each other is provided with regard to a particularly good dosability of the applied holding forces. In addition, a needle cap (2) made of comparatively soft, elastic material is provided as a seal and sealing closure for the hollow needles (40, 42) provided as actual transfer channels in the connection component (2).

Systems for destroying or inhibiting cancer cells and other rapidly-dividing cells including an alternating polarity (AP) magnetic field generator and at least one AP electromagnetic coil adapted to be coupled to a target body area, and a controller to control the AP magnetic field generator and at least one AP electromagnetic coil and cause the field generator and coil to apply AP magnetic field having a frequency of 0.5-500 kHz and a field strength of 0.5-5 mT to the target body area to achieve a desired inhibiting effect on cancer cells or other rapidly-dividing cells. Treatments provided by the system may be co-administered with an anti-cancer drug such as a chemotherapy drug, a hormone therapy drug, targeted therapy drugs, immunotherapy drugs, or an angiogenesis inhibitor drug.

Systems and method for destroying or inhibiting cancer cells and other rapidly-dividing cells include applying AP magnetic fields having a frequency of 0.5-500 kHz and a field strength of 0.5-5 mT to a target body area that includes the cancer or other rapidly-dividing cells.

Devices, systems, and methods used to compound a first medicament and second medicament are disclosed. The devices include a single-use or single-dose vial containing a first medicament and configured to receive an ampule containing a second medicament. The vial includes a stopper and needle configured to inject the first medicament into the ampule to compound with the second medicament.

A drug mixing system including at least one receptacle port adaptor adapted to be inserted into a port of a fluid receptacle, at least one syringe adaptor adapted to be attached to a syringe and to the at least one receptacle port adaptor and at least one vial adaptor adapted for connection to a vial containing a drug and adapted for connection to the at least one syringe adaptor, the system being characterized in that at least one of the receptacle port adaptor, the at least one syringe adaptor and the at least one vial adaptor being vented to the atmosphere in a manner which prevents release to the atmosphere of possibly harmful contents of the vial in a liquid, solid or gaseous form.

In certain embodiments, a vial adaptor for removing liquid contents from a vial comprises a piercing member and a bag. The bag can be contained within the piercing member such that the bag is introduced to the vial when the vial adaptor is coupled with the vial. In some embodiments, the bag expands within the vial as liquid is removed from the vial via the adaptor, thereby regulating pressure within the vial. In other embodiments, a vial comprises a bag for regulating pressure within the vial as liquid is removed therefrom. In some embodiments, a vial adaptor is coupled with the vial in order to remove the liquid. In some embodiments, as the liquid is removed from the vial via the adaptor, the bag expands within the vial, and in other embodiments, the bag contracts within the vial.

A safety vial system has a vial adapter subsystem irreversibly mountable to the top of a vial containing a hazardous medicament and a vial base subsystem sealingly engaging a lower portion of the vial adapter subsystem and telescopically movable therein from a first position providing a path for gas sterilization around the vial to a second position wherein the path is closed to form a sterilized expandable, neutral pressure bellows chamber around and below the vial. The device has a removable top cap, a pierceable barrier film, a normally closed needleless valve in fluid communication with a dual lumen spike initially disposed above the film and a frangible product integrity ring holding the activation housing in place for sealed telescopic movement on a main body that surrounds the vial. The user pulls the product integrity ring and removes it, and then pushes the activation housing axially downward until it clicks to lock the device in the activated position wherein both lumens of the spike are in communication with the inside of the vial. The user removes the top cap on the activation housing assembly, and then uses a needleless syringe with an adapter thereon to add diluent and mixes if needed and withdraw drug from the vial via the valve.