A drug preparation kit is disclosed that includes an adapter and a funnel unit. The adapter has a stud section with an in-container side and an out-container side. The stud section of the adapter is dimensioned to tightly fit into an opening of a container. The adapter has an access passage extending from the out-container side to the in-container side through the stud section. The funnel unit has a neck portion dimensioned to tightly fit into the access passage of the adapter. The funnel unit has a degassing channel formation arranged to provide a degassing channel extending from the in-container side of the stud section of the adapter to the out-container side of the stud section of the adapter when the neck portion of the funnel unit is fitted into the access passage of the adapter.

In one aspect, a combinatorial drug delivery device is provided for delivering a predetermined selection of drug components. The device includes a plurality of modules, each including: a body having an interior volume; a spike plate movably disposed in the interior volume, the spike plate having a protruding cannula and first and second ports. The device also includes a base tray which includes: a framework defining a plurality of wells, each of the wells formed to insertingly receive one of the modules; for each of the wells, first and second inlet ports formed to interface with the first and second ports of the module being received in the respective well; passageways to connect certain wells with adjacent wells to permit fluid flow therebetween. For each of the wells, the spike plate of the respective module being maintained in a stationary position with the module being inserted into the well.

The invention relates to an adapter (1) for a transfer device (20) for a fluid, for the connection of a container (17) containing the fluid, wherein the container (17) is closed by a pierceable closure element (18), and the adapter (1) has an attachment (4) which can be fitted sealingly, in an attachment direction, onto a container mouth closed by the closure element. A penetration element (6) is mounted on the attachment (4) in such a way that the penetration element (6) is movable, with the aid of guide means, between a rest position (R) and a withdrawal position (E), wherein the penetration element (6) has a hollow needle (9) with which the closure element (18) can be pierced in the withdrawal position (E). The adapter (1) has a connector stub (3) with a coupling for the fluid-tight connection of a further adapter (1′), and a transfer channel (10) runs from a mouth on the connector stub (3) to a mouth on the hollow needle (9), such that the mouth of the transfer channel (10) on the connector stub (3) communicates with an interior of the connected container (17) in the withdrawal position (E) of the penetration element (6). The invention is characterized in that the connector stub (3) is arranged transversely, in particular substantially perpendicularly, with respect to the attachment direction (H), preferably on the penetration element (6).

An assembly for mixing drug components includes a housing to at least partially hold a first drug component container and a second drug component container. The assembly also includes a transfer member having first and second ends to fluidly couple the respective first and second drug component containers. The assembly further includes a pressure member to fluidly couple the first drug component container to a pressure generation chamber. In addition, the assembly includes an energy storage member to generate pressure in the pressure generation chamber to transfer a fluid from the first drug component container into the second drug component container. Moreover, the assembly includes an exit member to fluidly couple the second drug component container to an exterior of the assembly.

A closure for dispensing one or more active agents into a container comprises a sealed or sealable chamber having a breakable wall and a hollow piston slidably mounted in a piston guide. Said hollow piston comprises an outer wall having an end in the chamber and at least one ventilation aperture. Said end has a cutting formation. Said hollow piston is slidable in the piston guide between a ventilation position in which the at least one ventilation aperture allows ventilation of the chamber and a sealed position in which the at least one ventilation aperture is sealed to prevent ventilation of the chamber and a deployed position in which the cutting formation has broken through at least a portion of the breakable wall. The outer wall has a retaining formation which engages with the piston guide to releasably resist sliding of the hollow piston between the ventilation position and the sealed position and the deployed position. The hollow piston may have an outer wall, and said outer wall has an end within the chamber, facing the breakable wall, wherein the cutting end has a first edge having a cutting formation and a gap in said cutting formation.

In certain embodiments, a vial adaptor comprises a housing configured to couple the adaptor with a vial, an access channel, a regulator channel, and a regulator assembly. The access channel is configured to facilitate withdrawal of fluid from the vial when the adaptor is coupled to the vial. The regulator channel is configured to facilitate a flow of a regulating fluid from the regulator assembly to compensate for changes in volume of a medical fluid in the vial. In some embodiments, the regulator assembly includes a flexible member configured to expand and contract in accordance with changes in the volume of the medical fluid in the vial. In some embodiments, the flexible member is substantially free to expand and contract. In some embodiments, the flexible member is not partly or completely located in a rigid enclosure.

A closure for dispensing one or more active agents into a container comprises a sealed or sealable chamber having a breakable wall and a hollow piston slidably mounted in a piston guide. Said hollow piston comprises an outer wall having an end in the chamber and at least one ventilation aperture. Said end has a cutting formation. Said hollow piston is slidable in the piston guide between a ventilation position in which the at least one ventilation aperture allows ventilation of the chamber and a sealed position in which the at least one ventilation aperture is sealed to prevent ventilation of the chamber and a deployed position in which the cutting formation has broken through at least a portion of the breakable wall. The outer wall has a retaining formation which engages with the piston guide to releasably resist sliding of the hollow piston between the ventilation position and the sealed position and the deployed position. The hollow piston may have an outer wall, and said outer wall has an end within the chamber, facing the breakable wall, wherein the cutting end has a first edge having a cutting formation and a gap in said cutting formation.

An exemplary vial adapter may include a moveable member, an elongated member with a first passage, a second passage coupled to an expandable first reservoir, and a third passage coupled to an expandable second reservoir. In a first orientation of an exemplary vial adapter, a fluid may be directed through the first passage into the first reservoir or the second reservoir. In a second orientation of an exemplary vial adapter, a fluid may be drawn through the first passage and a fluid drawn through an air passage into the second passage. In a second orientation of an exemplary vial adapter, a fluid may be directed through the first passage and through the third passage into the second reservoir. In a first orientation of an exemplary vial adapter, a moveable member may be activated to direct a fluid from the second reservoir through the third passage.

The present disclosure discloses a feeding system for treating liquid medical waste. The feeding system comprises a receiving container for storing liquid medical waste and a feeding container for accommodating a coagulant. The feeding container comprises an outlet and a seal for closing the outlet, and the receiving container comprises a feeding connector with a feeding channel. The feeding container and the receiving container are provided with a guide mechanism comprising guide lugs and guide slots, and the feeding connector is provided with a plurality of splitting portions arranged along the circumferential direction of the feeding channel and spaced apart from each other by a certain distance. The guide mechanism allows the operation of rotating the feeding container by a predetermined angle relative to the receiving container, and this operation causes the splitting portions to cut the seal along the circumference of the feeding channel to destruct the seal, thereby causing the coagulant accommodated in the feeding container flows into the receiving container through the outlet. The present disclosure provides a safe and convenient operation manner for adding a coagulant into a storage container of liquid medical waste.

A topical applicator of the propel/repel type includes a reservoir, an attachable applicator cap, and a metered dosing system. The reservoir is suitable for mixing a topical formulation of multiple constituents using an electronic mortar and pestle and is closed using the applicator cap. Alternatively, the reservoir may be prefilled with a ready-to-use cream and medicament formulation, then sealed with a removable seal. The topical applicator can include a fast purge feature that overrides the metered dosing system to facilitate removal of air from the reservoir. The topical applicator can also include a one-way ratcheting feature to prevent reverse movement (repel) of the metered dosing system. Metered doses can be dispensed through holes in the applicator cap by rotating a knob, which has detent positions that correspond to discrete doses, and which provides audible and tactile feedback.