The invention relates in particular to a device (100) for collecting a sample of a liquid in a container, characterized in that it has: a housing (10) with a longitudinal axis (AL); a component (20, 20′, 20″) comprising: a body (26) provided with at least one channel (21) having a proximal end (21p) and a distal end (21d); a receptacle (24) fixed with respect to the body (26) and situated in the continuation of the proximal end (21p) of said at least one channel (21), said component (20) being mounted rotatably with respect to the housing (10) about the longitudinal axis of this housing (10) between a closure position, in which the distal end (21d) of said at least one channel (21) is closed by the housing (10), and an open position, in which the distal end (21d) of said at least one channel (21) is able to establish a fluidic communication with the container; and an elastic valve (30) housed in the receptacle (24).

An infusion adapter for connection with an infusion fluid container includes a connection portion configured to engage an injection port of an infusion fluid container, and a port configured to connect to an intravenous line, with the port in fluid communication with the connection portion. The connection portion includes a retaining ring extending radially outward from the connection portion, with the retaining ring configured to securely connect the infusion adapter to the infusion fluid container to substantially prevent disconnection of the infusion adapter from the infusion fluid container once the infusion adapter is connected to the infusion fluid container. The retaining ring includes an indicator configured to provide visualization of insertion of the connection portion into an injection port of an infusion fluid container.

A closure for use with a specimen collection container is disclosed. The closure includes a base portion having a first end adapted for engagement with an open end of the specimen collection container, and a second end adapted for receiving a portion of a syringe assembly therein. The closure also includes a luer fitting connected to the base portion and having at least one channel for venting an interior of the specimen collection container to atmosphere during introduction of a fluid specimen from the syringe assembly into the specimen collection container. The closure further includes a shielding portion connected to the base portion and adapted to transition from an open position in which fluid communication is established between the first end and the second end through the luer fitting, to a closed position in which the luer fitting is fully shielded by the shielding portion.

The invention concerns a method and an apparatus for transferring an amount of a liquid drug (11) from a supply container (1) having stored the liquid drug (11) to a collapsible reservoir (2), the method including and the apparatus enabling the steps of: a) providing a fluid connection (3) between the supply container (1) and the collapsible reservoir (2); b) subjecting the liquid drug (11) stored in the supply container (1) to an environmental pressure; c) subjecting the collapsible reservoir (2) to a positive pressure relative to the environmental pressure, thereby collapsing the collapsible reservoir (2) and transferring gas comprised in the collapsible reservoir (2) from the collapsible reservoir (2) to the supply container (1); d) subjecting the collapsible reservoir (2) to a negative pressure relative to the environmental pressure, thereby expanding the collapsible reservoir (2) and transferring the amount of the liquid drug (11) from the supply container (1) to the collapsible reservoir (2).

The package comprises a sterile bag (3) filled with liquid diluent, a bottle (9) equipped with a pierceable cap (26) to contain a medicinal or nutritional substance and a tube (12) extending from the bag and ending with a coupling and perforation device (16) for the cap of the bottle. Said bag is housed in a flexible sterile sealed casing (1), while the bottle and the coupling and perforation device are accommodated in a second flexible sterile sealed casing (2). The tube (12) has a portion (13) between the first and second casing, housing a flow diverter (18) adjustable from a first position in which it impedes any communication between the bottle and the bag, to a second position in which it allows the bag to be put in communication with a sealed side opening (19) for a syringe (22), or a third position in which it allows the bottle to be connected with said side opening. To another side opening (41) of the flow diverter a flexible tube (42) with hydrophobic filter (43) is attached, terminating into one and/or the other of said sterile sealed casings and serving as a pressure compensator.

Transfer devices with vial adapter and/or an infusion set for reducing overdosing/underdosing of an infusion bag are provided. The transfer device provides user- controlled fluid transferring between an infusion liquid container and a drug-containing container. In one aspect, the transfer device provides user-controlled venting that can be used during liquid transfer between the infusion liquid container and a drug-containing container.

A syringe adapter includes a housing having a first end and a second end positioned opposite the first end, with the housing including a connector body positioned at the first end of the housing and configured to be secured to a syringe barrel, a cannula positioned within the housing, with the cannula defining a transfer opening and a valve opening, a seal arrangement positioned within the housing and movable within the housing, and an aspiration assembly comprising an aspiration housing defining an aspiration opening, a filter received by the aspiration housing, and one-way valve received by the aspiration housing, where the valve opening of the cannula is positioned within the aspiration housing, and where air is configured to flow into the filter via the aspiration opening, into the one-way valve, and into the valve opening of the cannula.

A piercing part for a medical infusion system includes a housing with a piercing mandrel, a fluid channel and a ventilation channel with a first channel portion extending at least substantially parallel to the fluid channel and with a second channel portion diverted towards an outside of the housing and to which an air filter element and a fluid shut-off member are assigned. A drip chamber can include a piercing part. The piercing part can be produced by an injection molding tool. The second channel portion in the housing is oriented parallel to the first channel portion and open towards an inside of the housing. An open region of the channel portion is closed by a separately produced closure part. The piercing part can be used with a medical infusion system.

In one aspect, the subject invention is directed to a method of preparing a combinatorial drug delivery device based on a predetermined selection of drug components. The method includes: preparing a plurality of containers, each accommodating one of the selected drug components; coupling the containers to a common outlet so that the drug components may be extracted from the containers and dispensed through the common outlet; and, applying negative pressure to extract the drug components from the containers and urge the drug components towards the common outlet.

A drug mixing system including at least one receptacle port adaptor adapted to be inserted into a port of a fluid receptacle, at least one syringe adaptor adapted to be attached to a syringe and to the at least one receptacle port adaptor and at least one vial adaptor adapted for connection to a vial containing a drug and adapted for connection to the at least one syringe adaptor, the system being characterized in that at least one of the receptacle port adaptor, the at least one syringe adaptor and the at least one vial adaptor being vented to the atmosphere in a manner which prevents release to the atmosphere of possibly harmful contents of the vial in a liquid, solid or gaseous form.