In certain embodiments, a vial adaptor for removing liquid contents from a vial comprises a piercing member and a bag. The bag can be contained within the piercing member such that the bag is introduced to the vial when the vial adaptor is coupled with the vial. In some embodiments, the bag expands within the vial as liquid is removed from the vial via the adaptor, thereby regulating pressure within the vial. In other embodiments, a vial comprises a bag for regulating pressure within the vial as liquid is removed therefrom. In some embodiments, a vial adaptor is coupled with the vial in order to remove the liquid. In some embodiments, as the liquid is removed from the vial via the adaptor, the bag expands within the vial, and in other embodiments, the bag contracts within the vial.

An object is to provide an apparatus and method for generating a hydrogen-containing liquid that are capable of generating a hydrogen-containing liquid of which the hydrogen concentration after 10 minutes exceeds 6 ppm and the hydrogen concentration after 24 hours exceeds 10 ppm. The apparatus comprises a hydrogen generating agent (11) reacting with water to generate hydrogen gas, a capsule (20) configured to be charged with the hydrogen generating agent (11) and discharge the hydrogen gas generated in the capsule (20) to external, and a container (3) configured to be charged with a liquid (L) that is an object to which the hydrogen gas generated in the capsule (20) is added. The ratio (V/W) of a volume (V ml) of the capsule (20) to a weight (W g) of the hydrogen generating agent (11) is 11.4 or less and more preferably 8.2 or less.

In certain embodiments, a vial adaptor for removing liquid contents from a vial comprises a housing and a bag. In some embodiments, an initial volume of a regulating fluid can be contained within the bag. In some embodiments, the regulating fluid flows into the vial as liquid is removed from the vial via the adaptor, thereby regulating pressure within the vial. In some embodiments, a vial adaptor is coupled with the vial in order to remove the liquid. In some embodiments, as the liquid is removed from the vial via the adaptor, the bag expands, and in other embodiments, the bag contracts.

The invention relates to a device (1) for reconstituting a pharmaceutical composition from at least a first component contained in a first container (2A) and a second component contained in a second container (2B), comprising: a fluidic unit (100) comprising: a first connector (101) coupled to the first container (2A), a second connector (102) coupled to the second container (2B), a pump (103), a fluidic circuit (104) connecting the first connector (101), the second connector (102) and the pump (103), wherein the first connector (101) comprises a crankpin (1011) in rotating engagement within a body (1010), said crankpin comprising a unique axial port (1011A) intended to fluidically couple to the first container, a radial port (1011B) fluidically connected to said axial port (1011A), and at least one channel (1011C) arranged therein so as to cooperate with the radial ports of the body (1010) to selectively connect the axial port (1011A) of the first connector with at least one channel portion of the fluidic circuit (104) depending on the angular position of the crankpin (1011) with respect to the body (1010), a power unit (200) releasably coupled to the fluidic unit (100), comprising: a power mechanism (203) for actuating the pump, transmission means connected between an actuator and the crankpin (1011) for rotating the first container (2A).

According to some embodiments of the present disclosure, an adaptor configured to couple with a sealed vial can include a connector interface. The adaptor can include one or more access channels (e.g., passages). In some cases the one or more access channels are in fluid communication with the connector interface. The adaptor can include a piercing member. The piercing member can include a regulator channel. The adaptor can include a regulator assembly. The regulator assembly can include a first regulator inlet. In some cases, the regulator includes a second regulator inlet. One or more of the first and second regulator inlets can include a filter configured to filter fluid passing into and/or out of the respective regulator inlets. One or more valves can be positioned between the first and/or second regulator inlets and the piercing member.

A template frame for holding a container and one or more additional components in a predetermined first arrangement is disclosed. The template frame has a first pair of stanchions for engaging the container; and additional pairs of stanchions provided for engaging the one or more additional components, wherein each of the additional pairs of stanchions is for engaging one of the one or more additional components, wherein the stanchions are arranged on the template frame for holding the container and the one or more additional components out of direct physical contact from one another in the predetermined first arrangement to be subsequently assembled into a second arrangement

The present disclosure is directed to a vial adapter for interconnecting a vial and a fluid delivery device, and, more particularly, to a vial adapter having a modular design consisting of separately constructed components cooperatively arranged and coupled to one another. The modular construction allows for rapid manufacturing reconfigurations of one or more components with minimal costs to create new vial adapter configurations that meet specific needs.

A vial access device is described comprising an upper housing having a fluid connecter in fluid communication with the upper housing; a vial access spike projecting from the upper housing; a fluid filter body within the upper housing or connectable thereto, the fluid filter body in fluid communication with the vial access spike and the fluid connector. Methods of reducing or eliminating particulate matter from medicament solutions are also provided.

A system for manufacturing parenteral solutions includes a drug dosage module and a mixing module. The drug dosage module includes a source of one or more parenteral drug solutes, and one or more metering devices configured to discharge a metered dosage of each of the parenteral drug solutes. The mixing module includes a container configured to receive water-for-injection (WFI) and the parenteral drug solutes discharged from the one or more metering devices, and a mixer configured to mix water-for-injection (WFI) and the parenteral drug solutes in the container to form a parenteral solution.

The drug delivery device (1) connects an syringe barrel (6) and a drug container (2) by means of a closed system, and delivers a drug between the syringe barrel and drug container through said closed system. This drug delivery device includes a first member (8) connected to the drug container (2) on the side of a stopper (4), and a second member (30) connected at one end to the first member and connected at the other end to the syringe barrel (6). The first member and the second member are connected by a fitting mechanism. A second hollow needle member (34) provided on the second member faces towards the first member, and the tip portion (36) and the base portion (38) are fixed. The first member has a first hollow needle member (12). The first member and the second member each have an elastic member (18 and 40).