This drug delivery device delivers a drug between a syringe barrel and a drug container, and, by enveloping the entire the drug container used in drug delivery, prevents exposure to hazardous drugs adhering to the drug container. This drug delivery device includes: a first member connected to the drug container on the side of a stopper; a second member connected to the first member and to the syringe barrel; and a third member connected to the first member and covering the drug container in a sealed state. The first member has a first hollow needle member and a drug container holder, and the second member has a second hollow needle member. The third member has an opening portion, a bottom surface portion where the drug container is stably mounted, and a flexible member which is connected to the opening portion and the bottom surface portion.

The package comprises a sterile bag (3) filled with liquid diluent, a bottle (9) equipped with a pierceable cap (26) to contain a medicinal or nutritional substance and a tube (12) extending from the bag and ending with a coupling and perforation device (16) for the cap of the bottle. Said bag is housed in a flexible sterile sealed casing (1), while the bottle and the coupling and perforation device are accommodated in a second flexible sterile sealed casing (2). The tube (12) has a portion (13) between the first and second casing, housing a flow diverter (18) adjustable from a first position in which it impedes any communication between the bottle and the bag, to a second position in which it allows the bag to be put in communication with a sealed side opening (19) for a syringe (22), or a third position in which it allows the bottle to be connected with said side opening. To another side opening (41) of the flow diverter a flexible tube (42) with hydrophobic filter (43) is attached, terminating into one and/or the other of said sterile sealed casings and serving as a pressure compensator(Fig. 1).

In certain embodiments, a vial adaptor for removing liquid contents from a vial comprises a piercing member and a bag. The bag can be contained within the piercing member such that the bag is introduced to the vial when the vial adaptor is coupled with the vial. In some embodiments, the bag expands within the vial as liquid is removed from the vial via the adaptor, thereby regulating pressure within the vial. In other embodiments, a vial comprises a bag for regulating pressure within the vial as liquid is removed therefrom. In some embodiments, a vial adaptor is coupled with the vial in order to remove the liquid. In some embodiments, as the liquid is removed from the vial via the adaptor, the bag expands within the vial, and in other embodiments, the bag contracts within the vial.

A convenience kit being formed by a pair of associated sub-kits which provide capability for bench-top medicine prescription compounding without need for clean room surroundings or such protective equipment as laminar flow hoods. The sub-kits include an exterior sub-kit which provides for access, volumetric measurement and compounding of medicine derived from vials and an enclosing sub-kit housed within a plastic bag which provides a sterile environment for filling a medical treatment vessel for use. The two sub-kits are joined together and communicate by bag entry technology to provide a system which not only protects and, in some cases, provides product sterility, but also assures full containment of all fluid being used in a medical preparation.

In certain embodiments, a vial adaptor comprises a housing configured to couple the adaptor with a vial, an access channel, a regulator channel, and a regulator assembly. The access channel is configured to facilitate withdrawal of fluid from the vial when the adaptor is coupled to the vial. The regulator channel is configured to facilitate a flow of a regulating fluid from the regulator assembly to compensate for changes in volume of a medical fluid in the vial. In some embodiments, the regulator assembly includes a flexible member configured to expand and contract in accordance with changes in the volume of the medical fluid in the vial. In some embodiments, the flexible member is substantially free to expand and contract. In some embodiments, the flexible member is not partly or completely located in a rigid enclosure.

A processing device (10) for a therapeutic product or biological sample is provided with a proximal end (12b) and a distal end (12a). The device includes first and second compartments (40, 42) and a first substantially tubular portion (20). The first compartment (40) is in fluid communication with the second compartment (42) via a filtered opening (28) which is arranged in or along the first substantially tubular portion (20). The processing device (10) may be provided in kit form. A method of using the processing device (10) or kit is also disclosed.

According to some embodiments of the present disclosure, an adaptor configured to couple with a sealed vial can include a connector interface. The adaptor can include one or more access channels (e.g., passages). In some cases the one or more access channels are in fluid communication with the connector interface. The adaptor can include a piercing member. The piercing member can include a regulator channel. The adaptor can include a regulator assembly. The regulator assembly can include a first regulator inlet. In some cases, the regulator includes a second regulator inlet. One or more of the first and second regulator inlets can include a filter configured to filter fluid passing into and/or out of the respective regulator inlets. One or more valves can be positioned between the first and/or second regulator inlets and the piercing member.

Presented herein are a robotic system that is configured for compounding and preparation of medications comprising non-hazardous drugs and a vented drug vial adapter. The robotic system comprises: a laminar flow cabinet; and at least one robotic arm. The vented drug vial adapter is designed to connect a drug vial to another component of a drug transfer system. The adapter comprises a hydrophobic filter that prevents passage of liquid while allowing air to pass through it and a vent hole to the atmosphere. The vent hole is located above the filter thereby allowing equalization of the internal pressure while preventing the drug from contaminating the atmosphere.

A package includes a sterile bag filled with liquid diluent, a bottle equipped with a pierceable cap to contain a medicinal or nutritional substance, and a tube extending from the bag and ending with a coupling and perforation device for the cap of the bottle. The bag is housed in a flexible sterile sealed casing. The tube has a middle portion located between the first casing and the bottle. The package includes an adjustable flow diverter disposed in the middle portion of the tube. The adjustable flow diverter includes a first side opening to receive a syringe. The package includes a pressure compensator that includes a flexible tube with a hydrophobic filter connected to a second side opening of the flow diverter and terminates in the first casing.

In certain embodiments, a vial adaptor comprises a housing configured to couple the adaptor with a vial, an access channel, a regulator channel, and a regulator assembly. The access channel is configured to facilitate withdrawal of fluid from the vial when the adaptor is coupled to the vial. The regulator channel is configured to facilitate a flow of a regulating fluid from the regulator assembly to compensate for changes in volume of a medical fluid in the vial. In some embodiments, the regulator assembly includes a flexible member configured to expand and contract in accordance with changes in the volume of the medical fluid in the vial. In some embodiments, the flexible member is substantially free to expand and contract. In some embodiments, the flexible member is not partly or completely located in a rigid enclosure.