A mixing and/or reconstitution system reduces the possibility of user error and provides a well mixed and/or reconstituted drug in a short time. The system comprises a device containing a first material within a first chamber, a housing, and a plunger, the plunger comprising a second chamber containing a second material, wherein one of the first and the second material is a fluid, and a movable element with an electric, magnetic, or paramagnetic characteristic, wherein the second chamber is initially closed; and a base unit comprising a recess for accommodation of the device, a control unit, and an electromagnetic unit which is adapted to produce an electromagnetic field penetrating the recess, wherein the control unit can electrically operate the electromagnetic unit such that the element contained in the second chamber moves in a direction of the device determined by the electromagnetic field and fluidly communicates the first and second chambers.

A convenience kit for sterilizing and delivering liquids into the safety of a sterile environment inside a plastic bag (which can be disposed in a field environment) wherein a so sterilized liquid is dispensed into a vessel which is capped and sealed before removal from the bag. The convenience kit can be provided in a solitary format or, as a subkit combined with other associated items in a more inclusive convenience kit. In short, convenience kits made according to the present invention provide opportunity for accomplishing an aseptic liquid sterilizing transfer, a task which is commonly associated with on-hand capability of a laminar flow hood, in field environments and other areas which are remote from facilities having laminar flow hoods.

Vessel having sterile contents containing in predetermined proportions (i) a foamable liquid and (ii) a gas or gas mixture other than air. The contents are at a pressure above atmospheric pressure. The vessel has an outlet which is adapted to cooperate with a syringe nozzle and which has associated with it a breakable seal or a valve.

A vial adapter for reconstituting a drug and drawing a drug from a vial. The vial adapter includes a passageway for passage of a diluent into the vial to mix with and reconstitute the drug and a chamber containing the reconstituted drug drawn from the vial. A vacuum is applied through the adapter to draw the reconstituted drug from the vial. The reconstituted drug can be accessed in one or two ways, either via a luer locked syringe or via a needled syringe.

A closure for an ampoule, the closure comprising: a cap portion arranged to engage with a broken neck of an opened ampoule; and a cylindrical skirt portion extending from the cap portion, the skirt portion being elastically deformable and being arranged to move from a first position in which it is at least partially folded back on itself to a second position in which it is unfolded and extends away from the cap portion. The closure can close off an opening such as that formed in an ampoule when the neck is snapped and the top removed. As the cap portion engages with the broken neck, it reduces the chances of users receiving lacerations from the sharp edges. The cap portion also seals the ampoule, preventing the contents from being spilled and/or wasted. The closure also provides a degree of impact protection, reinforcement and strengthening to the now weakened open end of the ampoule, e.g. in case the ampoule is dropped. The skirt portion not only provides a seal around the ampoule body by being in close contact therewith, but also holds the cap portion firmly against the broken rim of the open ampoule, thus holding the closure in place by means of the friction between the skirt portion and the outer surface of the ampoule body.

A device for aseptic delivery of biological material from a vial includes a tubular barrel, a filter assembly, and a dispersion assembly. The dispersion assembly is at least partially disposed within the tubular barrel. The dispersion assembly includes a dispersion element, a piston, and a one-way valve. The dispersion element is in fluid communication with the vial to disperse the biological material from the vial. The piston is disposed at the distal end of the dispersion assembly and is in sealing contact with the tubular barrel. The one-way valve forms a fluid passageway in fluid communication with the dispersion element and the tubular barrel. The one-way valve is configured to allow a flow of the dispersed biological material from the dispersion element, through the fluid passageway, and into the tubular barrel, and to prevent a flow of the dispersed biological material from the tubular barrel into the dispersion assembly.

A system for reconstituting and sterilizing a concentrate includes a mixing container, a filtration device, and a product bag. The a mixing container has an inlet port and outlet port in fluid communication with a mixing chamber disposed between the inlet port and the outlet port. The mixing chamber is adapted to contain a product concentrate. The filtration device has an inlet and an outlet, the inlet of the filtration device coupled to the outlet port of the mixing container. The filtration device includes a filter membrane with a nominal pore size in a range of approximately 0.1 m to approximately 0.5 m. The product bag has an inlet port coupled to the outlet of the filtration device, and has a bladder defining an empty sterile chamber for receiving sterilized and reconstituted product resulting from mixing a diluent with a product concentrate in the mixing chamber to obtain a mixture then introduced through the filtration device to obtain the reconstituted and sterilized product.

A vial and system are configured to simplify fluid input and extraction therefrom. The vial has a first end opposite a second end and with a collapsible sidewall. The sidewall can be collapsed, such as by imparting a differential pressure between an interior and exterior of the vial, for simplified fluid extraction and smooth extraction without disturbing boundaries between separated components. The vial typically has a bulb at a first end and a neck extending away from the bulb and toward the second end. An inlet spaced from the first end can be configured to attach to various different interfaces or processing elements for input and output of fluids. A support cup can be provided for use with the vial during centrifugation to allow the vial to withstand any centrifugation forces. Various fluid processing methodologies are supported by the collapsible vial, especially including methods of separation of components of blood.

A liquid handling system and method, e.g., for testing blood samples. The system comprises a cartridge, and a transfer device couplable to a liquid reservoir. The cartridge comprises compartments with an inlet, closed by a seal, and an outlet, closed by a gas-permeable liquid-tight filter. Keying portions define a relative position and orientation of the cartridge and the transfer device. Penetrating elements of the transfer device penetrate the seal of each compartment, the penetrating elements having lumina for fluidly connecting the reservoir and each compartment cavity of the cartridge.

A bone fragment and osteomedullary tissue harvesting system that includes a harvesting device, a collection vessel and tubing. The harvesting device includes a needle portion and a handle portion. The needle portion that has a needle bore that extends through at least part of the needle portion. The handle portion is operably attached to the needle portion. The handle portion includes a connection port and a vacuum control mechanism that are in communication with a handle bore that extends through the handle portion. The needle bore is in communication with the handle bore. The vacuum control mechanism includes a vacuum aperture that extends through a surface of the handle portion and is in communication with the handle bore. The collection vessel is capable of receiving aspirated bone fragments and tissue. The tubing operably connects the connection port and the collection vessel.