Patent classifications
A61K31/4355
TETRAHYDROPYRIDO[3',2':4,5]PYRROLO[1,2-a]PYRAZINE-2-CARBOXAMIDE DERIVATIVES USEFUL AS RSK INHIBITORS
Described herein are carboxamide derivatives that are useful as inhibitors of p90 ribosomal S6 kinase (RSK), pharmaceutical compositions comprising the derivatives, and methods of using the derivatives in treating diseases or conditions associated with RSK activity.
AMINO ACID TRANSPORT INHIBITORS AND THE USES THEREOF
These compounds are glutamine transporter inhibitors, e.g., alanine, serine, cysteine-preferring transporter 2 (ASCT2) inhibitors. Glutamine transporter inhibitors are useful to treat a variety of diseases, disorders, or conditions including cancer.
AMINO ACID TRANSPORT INHIBITORS AND THE USES THEREOF
These compounds are glutamine transporter inhibitors, e.g., alanine, serine, cysteine-preferring transporter 2 (ASCT2) inhibitors. Glutamine transporter inhibitors are useful to treat a variety of diseases, disorders, or conditions including cancer.
Inhibitors of short-chain dehydrogenase activity for treating coronary disorders
A method of treating preventing, minimizing, and/or reversing congestive heart failure, cardiomyopathy, and/or reduction of cardiac ejection fraction in a subject in need thereof includes administering to the subject a therapeutically effective amount of a 15-PGDH inhibitor.
Inhibitors of short-chain dehydrogenase activity for treating coronary disorders
A method of treating preventing, minimizing, and/or reversing congestive heart failure, cardiomyopathy, and/or reduction of cardiac ejection fraction in a subject in need thereof includes administering to the subject a therapeutically effective amount of a 15-PGDH inhibitor.
METHOD FOR RELIEF OF AND TREATMENT OF PRURITUS
A method for treating pruritus by topically applying a composition comprising a hedgehog inhibitor compound is provided.
METHOD FOR RELIEF OF AND TREATMENT OF PRURITUS
A method for treating pruritus by topically applying a composition comprising a hedgehog inhibitor compound is provided.
Methods of treating cancer using PD-1 axis binding antagonists and MEK inhibitors
The present invention describes combination treatment comprising a PD-1 axis binding antagonist and a MEK inhibitor and methods for use thereof, including methods of treating conditions where enhanced immunogenicity is desired such as increasing tumor immunogenicity for the treatment of cancer.
Methods of treating cancer using PD-1 axis binding antagonists and MEK inhibitors
The present invention describes combination treatment comprising a PD-1 axis binding antagonist and a MEK inhibitor and methods for use thereof, including methods of treating conditions where enhanced immunogenicity is desired such as increasing tumor immunogenicity for the treatment of cancer.
Small molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and uses thereof
Provided herein are small molecule activators of Nicotinamide Phosphoribosyltransferase (NAMPT), compositions comprising the compounds, and methods of using the compounds and compositions.