[Problem]

To provide a compound having a 15-PGDH inhibitory effect.

[Solution]

A compound represented by general formula (1) or a pharmacologically acceptable salt thereof.

The present invention relates to a combination product and its use in therapy.

The present invention relates to a combination product and its use in therapy.

The present invention relates to novel Amido-Substituted Heterocycle Compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein X, R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are as defined herein. The present invention also relates to compositions comprising at least one Amido-Substituted Heterocycle Compound, and methods of using the Amido-Substituted Heterocycle Compounds for treating or preventing a herpesvirus infection in a patient.

##STR00001##

The present invention relates to novel Amido-Substituted Heterocycle Compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein X, R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are as defined herein. The present invention also relates to compositions comprising at least one Amido-Substituted Heterocycle Compound, and methods of using the Amido-Substituted Heterocycle Compounds for treating or preventing a herpesvirus infection in a patient.

##STR00001##

The present disclosure relates generally to therapeutic agents that may be useful as modulators of Integrated Stress Response (ISR) pathway.

The present disclosure relates generally to therapeutic agents that may be useful as modulators of Integrated Stress Response (ISR) pathway.

A group of known compounds has been found to have polymerase inhibitor qualities and are presumed to be efficacious in the protection of human cells from damage by the SARS-CoV-2 virus, which causes the COVID-19 disease. These compounds, referred to herein as Special Phenyl Compounds, provide such protection by inhibiting replication of the virus, which is done by interfering with its RNA transcription process. These compounds can also be used to treat diseases caused by structurally related viruses such as West Nile virus, Marburg virus, Ebola virus, dengue virus, HIV, hepatitis C virus (HepC), and coronaviruses other than SARS-CoV2. Patients are treated by administering effective doses of one or more of the compounds.

A group of known compounds has been found to have polymerase inhibitor qualities and are presumed to be efficacious in the protection of human cells from damage by the SARS-CoV-2 virus, which causes the COVID-19 disease. These compounds, referred to herein as Special Phenyl Compounds, provide such protection by inhibiting replication of the virus, which is done by interfering with its RNA transcription process. These compounds can also be used to treat diseases caused by structurally related viruses such as West Nile virus, Marburg virus, Ebola virus, dengue virus, HIV, hepatitis C virus (HepC), and coronaviruses other than SARS-CoV2. Patients are treated by administering effective doses of one or more of the compounds.

Described herein are compounds, compositions and methods useful for inhibiting Kelch-like ECH-associated protein 1 (KEAP1). The compounds, compositions and methods described herein are useful for treating diseases, disorders or conditions associated with KEAP1.