In a method of treating a patient having a solid tumor, the solid tumor is completely or partially resected or ablated and then a therapeutically-effective amount of an oligonucleotide that kills tumor cells is applied or administered in a body cavity created by the resection or ablation in order to kill tumor cells remaining in, or in the surroundings of, a tumor bed and/or to suppress metastases. Thus, the oligonucleotide counteracts the development of recurrences of the solid tumor or new metastases. The oligonucleotide may act, e.g., in a pleiotropic manner in at least one type of tumor cell.

The invention is directed to a composition comprising a fibrin hydrogel conjugated to peptides of laminin-111 (L1) and methods for repairing damaged salivary tissue using the composition.

The methods and compositions described herein address the need in the art by providing peptides and polypeptides comprising a growth factor binding domain. In some embodiments, the peptides have an amino acid sequence that is at least 80% identical to one of SEQ ID NOS:1-7, 13-15, 49-50, or 66-70, or a fragment thereof; wherein the peptide is less than 300 amino acids in length.

An atelocollagen according to an embodiment is characterized in that, when analyzed by high-performance liquid chromatography (HPLC), a peak area (Sβ) for a β chain is larger than a second peak area for an α chain (Sα2) so that, when a physiologically active material is loaded therein, the atelocollagen may decrease rapid initial release of the physiologically active material or may control reduction in effects of the physiologically active material due to too slow initial release. Further, the atelocollagen of the present invention may exhibit excellent cancer metastasis inhibitory effects.

The present disclosure relates to compositions, such as siRNA molecules and FN3 domains conjugated to the same, as well as methods of making and using the molecules.

The present disclosure relates to polypeptides, such as fibronectin type III (FN3) domains that can bind EpCAM, their conjugates, isolated nucleotides encoding the molecules, vectors, host-cells, as well as methods of making and using the molecules.

Provided herein are polypeptides which include tenth fibronectin type III domains (.sup.10Fn3) that bind to glypican-3. Also provided are fusion molecules comprising a .sup.10Fn3 domain that bind to glypican-3 for use in diagnostic and therapeutic applications. Glypican-3 .sup.10Fn3 drug conjugates are also provided.

The targeted delivery of growth factors, vasoactive peptides and other representative anabolic peptide drugs from different signaling cascades to bone fracture for accelerated healing is disclosed herein.

The present invention provides a biomatrix layer comprising, consisting essentially of or consisting of a sulfated oligosaccharide at a concentration in the range of 0.1 μM to 1,000 μM and a peptide-polyethylene glycol-conjugate according to formula (I): PEG-R1-(BX)n (I) wherein B is lysine or arginine, X is selected from alanine, glycine, serine, threonine, tyrosine, glutamic acid or aspartic acid and n is an integer selected from 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 and 20; R.sub.1 may be absent or is a peptide comprising 5 to 30 amino acids; PEG is comprised at a concentration in the range of 0.1 μM to 1,000 μM; R1, if present, is comprised at a concentration in the range of 0.1 μM to 4,000 μM; (BX)n is comprised at a concentration in the range of 0.25 μM to 1,000 μM. The invention further relates to processes for assembling the biomatrix layer. The biomatrix layer can be used in various biomedical applications, such as neuroprostheses, biosensors, nerve grafts, cell culture and encapsulation of cells and microorganisms as well as for drug delivery.

Described herein are targeting moieties that can be capable of specifically targeting muscle cells and can include an n-mer motif. In some embodiments, the n-mer motif contains an RGD motif. Also described herein are vector systems, particles, polypeptides that can encode and/or contain one or more targeting moieties. Also described herein are methods of delivering a cargo to a cell, such as a muscle cell, using one or more of the targeting moieties described herein.