The present disclosure relates to capillary dialyzers for blood purification, in particular, capillary dialyzers suitable for home hemodialysis systems.

Systems, devices, and methods are provided for removing carbon dioxide from a target fluid, such as, for example, blood, to treat hypercarbic respiratory failure or another condition. A device is provided including first and second membrane components for removing dissolved gaseous carbon dioxide and bicarbonate from the fluid, which can be done simultaneously. The device can be in the form of a cartridge configured for use in a dialysis system. A method of treatment is also provided, involving drawing blood from a patient and bringing the patient's blood in contact with a first membrane component having a sweep gas passing therethrough, and a second membrane component having a dialysate passing therethrough. The dialysate's composition can be selected such that charge neutrality is maintained.

Excess water can be removed from blood by passing the blood through channels that are surrounded by nanotubes with spaces therebetween. Each channel is wide enough for blood to flow through, and the nanotubes are spaced close enough to each other to retain the blood within the channels. Gas passing through the spaces between the nanotubes outside the channels comes into contact with the blood at the outer boundaries of the channels, and the excess water in the blood evaporates into the gas. In other embodiments, an undesirable molecule (e.g., ammonia) can be removed from blood by passing the blood through channels that are surrounded by nanotubes with spaces therebetween. Gas passing through the spaces between the nanotubes outside the channels comes into contact with the blood at the outer boundaries of the channels, and the undesirable molecule in the blood diffuses into the gas.

A molecule can be removed from blood by passing the blood through channels that are surrounded by nanotubes with spaces therebetween. Each channel is wide enough for blood to flow through, and the nanotubes are spaced close enough to each other to retain the blood within the channels. Gas passing through the spaces between the nanotubes outside the channels comes into contact with the blood at the outer boundaries of the channels, and the molecule in the blood diffuses into the gas. In other embodiments, a molecule can be introduced into blood by passing the blood through channels that are surrounded by nanotubes with spaces therebetween. Gas that includes the molecule passes through the spaces between the nanotubes outside the channels. The gas comes into contact with the blood at the outer boundaries of the channels, and the molecule in the gas diffuses into the blood.

Despite therapeutic advances in the field of oncology, treatment toxicity, drug resistance, and inadequate tumor site delivery restrict the benefit of cancer chemotherapy regimens. Disclosed are extracorporeal devices comprising adsorbent components that are suitable for treating a subject prior to and following administration of a dose of a chemotherapy drug, wherein the devices are configured to remove circulating factors comprising a chemotherapy drug from blood or plasma. Also disclosed herein are methods of reducing the bloodstream presence of circulating factors that mediate drug resistance, drug toxicity, and cancer metastasis, wherein circulating factors include without limitation, tumor-derived and/or chemotherapy-induced extracellular vesicles or exosomes.

The present invention provides a hollow fiber membrane oxygenator comprising a housing comprising a blood flow path; a blood inlet port and a blood outlet port disposed in the housing so as to allow blood to flow through the blood flow path; a gas exchange part comprising a bundle of a plurality of hollow fiber membranes disposed in the blood flow path, a gas inflow port and a gas outflow port provided in the housing so as to allow an oxygen-containing gas to flow through lumens of the hollow fiber membranes, and a gas temperature control part for adjusting the temperature of a gas flowing through the lumens of the hollow fiber membranes.

Dialyzer systems can consolidate multiple technologies and functionalities of blood treatment systems in a significantly integrated fashion. For example, this disclosure describes dialyzer systems that include a magnetically driven and magnetically levitating pump rotor integrated into the dialyzer. Such a dialyzer can be used with treatment modules that include a magnetic field-generating pump drive unit. In some embodiments, the dialyzers include pressure sensor chambers with flexible membranes with which corresponding pressure transducers of the treatment modules can interface to detect arterial and/or venous pressures.

Dialyzer systems can consolidate multiple technologies and functionalities of blood treatment systems in a significantly integrated fashion. For example, this disclosure describes dialyzer systems that include a magnetically driven and magnetically levitating pump rotor integrated into the dialyzer. Such a dialyzer can be used with treatment modules that include a magnetic field-generating pump drive unit. In some embodiments, the dialyzers include pressure sensor chambers with flexible membranes with which corresponding pressure transducers of the treatment modules can interface to detect arterial and/or venous pressures.

The present invention relates to a multi-stage blood purification apparatus designed to remove substances from a bodily fluid of a subject. In one aspect, the present invention relates to a sorbent stage containing a sorbent material by which a substance, or substances, is removed from a bodily fluid when in contact with the bodily fluid. In another aspect, the present invention provides a multi-stage blood purification apparatus containing a sorbent stage and a membrane stage. Further, methods of purifying a bodily fluid utilizing apparatuses of the present disclosure are provide.

To provide an optimized hemodialysis system such as capable of suppressing variations in a blood pressure according to the individual difference of a patient.

The system is configured to include: blood related information acquiring means configured to acquire blood flow information and patient biological information in a blood circuit for hemodialysis, the patient biological information being peripheral vascular resistance information, blood pressure information, face information, body movement information, temperature information, and humidity information and the like; individual difference information managing means configured to acquire and manage patient individual difference information from the blood related information; and optimized dialysis means configured to perform optimized dialysis treatment for the patients on the basis of the patient individual difference information.