A medicament delivery device comprising a cannula for delivery of medicament, a cartridge assembly comprising a cartridge having a medicament chamber and a collar adjacent a distal end opening of the chamber, a sealing element for sealing the distal end opening, and a coupling element for retaining the sealing element against a distal end of the cartridge. The device further comprises a hub assembly comprising a hub body and a sealing element release member. The device is switchable from a starting configuration in which the release member is spaced from the sealing element to an activated configuration in which the release member cooperates with the sealing element to connect the medicament chamber to the cannula. The coupling element comprises an annular clamping portion for applying a clamping force to the sealing element to seal the sealing element against the distal end of the cartridge, and a generally tubular engagement portion.

A medicament delivery device is disclosed, comprising a cartridge assembly that comprises a cartridge having a medicament chamber for containing a medicament, a sealing element for sealing a distal end of the medicament chamber and a coupling element attached to the cartridge. The device also includes a sealing element release member, a cannula for delivery of the medicament, and a removable cap. The device is switchable from a starting configuration in which the release member is spaced from the sealing element to an activated configuration in which the release member cooperates with the sealing element to connect the medicament chamber to the cannula. A proximal end of the release member is sealed in a release member chamber defined in part by, the sealing element and in part by the coupling element.

A cartridge (100) for packaging a medicament and being suitable for use with multiple different types of dosing device is described, together with dosing devices and adaptors for dosing devices. The cartridge includes a generally tubular body (102) having an interior cavity (104), a closure member (106) disposed at a distal end of the body and comprising a sealing element (128), a piston member (108) disposed in the cavity to contain the medicament between the piston member and the sealing element (128), a coupling element (114) disposed at the distal end of the body for coupling the cartridge to a dosing device (200) or to an adaptor for a dosing device, and a seal arrangement (126, 129) for receiving a sealing element release member (214) of the dosing device or adaptor. The coupling element (114) is arranged for engagement with an engagement part (220) of the dosing device or adaptor to clip the cartridge (100) to the dosing device or adaptor (200) upon insertion of the cartridge to the dosing device or adaptor, and the seal arrangement (126, 129) is disposed distally with respect to the sealing element (128) and is arranged to form a seal around the release member (214; 254) when the cartridge is coupled to the dosing device or adaptor.

In one aspect, a connector assembly includes a delivery conduit defining a conduit lumen and a securable connector configured to secure the delivery conduit to a medical device hub defining a medical device hub lumen. The conduit lumen includes a constant diameter region along a portion of the delivery conduit and a transition region extending from the delivery conduit to the distal end. A transition region diameter of the transition region gradually increases from the constant diameter region to a distal end of the delivery conduit. The securable connector is coupled to an outer surface of the delivery conduit and is slidable along a portion thereof. The securable connector is configured to receive the medical device hub. The securable connector is secured relative to the delivery conduit so as to fluidically couple the conduit lumen with the medical device hub lumen.

An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.

A discharger for discharging a predetermined amount of fluid includes a housing defining a longitudinal first axis and having a proximal end and a distal end, a discharge section having a discharge passage for the fluid extending between an inlet opening and an outlet opening of the discharge section, a carriage cooperating with the proximal end region of the housing such that the carriage is moveable relative to the housing along the first axis, the carriage including a receiving space for the fluid, and a piercing tip having a flow channel for establishing a flow connection for the fluid from the receiving space to the inlet opening of the discharge section, the piercing tip defining a centrally extending longitudinal second axis and having a shell surface. The shell surface of the piercing tip has an essentially convexly curved.

The invention relates to an injection device which includes a handle and a guard which together enclose a movable cartridge which can contain liquid material to be injected, and further enclose a movable injector that includes a needle, the needle being attached to a housing where the housing is attached to the cartridge, the device also including a delivery mechanism whereby the needle is moved from a retracted to an extended position, and independently the volume of the chamber may be adjusted to expel the contents thereof through the needle and into a subject in need thereof. The injection device may be communicatively connected to a control unit so as to provide a dermal injection system.

The present disclosure relates to a drug delivery device (10), comprising a housing (11) adapted to receive a primary package (24), the housing (11) comprising a distal surface (11.1) adapted to be placed against an injection site and a proximal surface (11.2) opposite the distal surface (11.1), the proximal surface (11.2) adapted to be held in the palm of a user's hand during drug delivery, the housing (11) having a flat form-factor in such a manner that a first extension of the housing (11) between the distal surface (11.1) and the proximal surface (11.2) is less than at least one extension at right angles to the first extension.

Multiphase microspheres for radioembolization include two-phase microspheres and three-phase microspheres prepared by a microfluidic process. The multiphase microspheres include a primary phase and a first secondary phase surrounded by the primary phase. The primary phase includes a first resin. The first secondary phase includes a second resin and at least one of a radioactive isotope or a compound including at least one radioactive element. Three-phase microspheres additionally include a second secondary phase discrete from the first secondary phase and also surrounded by the primary phase. The second secondary phase may be a gas such as air. The microspheres may be formed by a microfluidic process.

Apparatus for removably attaching a syringe to a container for extracting fluid therefrom into the syringe, which is particularly beneficial for fluid having a relatively high viscosity. The disclosed container adapter holds a syringe adapter securely therein (the syringe adapter configured for providing a fluid path between a container and a syringe) while also securing the syringe adapter to the container, and provides an attachment point for securely attaching the syringe to the syringe adapter and thus to the container (at least) while the fluid is withdrawn from the container into the syringe. The syringe is removably attached to an end of the syringe adapter during the withdrawal, and a cap is provided that closes entry and exit to this attachment point when the syringe is not in place. The cap preferably attaches to the syringe adapter using a connection that mimics the connection used by the syringe.