An injector may include a container having a wall with an interior surface defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a sterile container needle that is in fluid communication with the container in a delivery state, but may or may not be in fluid communication with the container in a storage state. Further, the injector may include an actuator that is adapted to move the container needle from the storage state to the delivery state.

Methods and systems for selection of dosimetry levels and sphere amounts of radioactive compounds for use in a radioembolization procedure for procedure planning may include inputting activity parameter information into a dosimetry portal of a dosimetry selection tool; determining a customized activity based on the activity parameter information and one or more customized activity algorithms; generating one or more sphere amount and dosage recommendations based on the customized activity and one or more dosimetry selection algorithms; selecting one of the one or more sphere amount and dosage recommendations as a selected sphere amount and dosage recommendation; and generating a radioactive compound order for the radioembolization procedure based on the customized activity and the selected sphere amount and dosage recommendation.

Handheld drug delivery devices for injection of a medicament into a target location are disclosed herein. The drug delivery devices of the present disclosure include drive mechanisms, needle insertion mechanisms, and fluid pathway connectors. These components may be arranged within a housing. The arrangement of these components may provide an easy to use device that is capable of delivering volumes larger than traditionally injected using syringes. Translation of a drug container of the device may cause connection of a fluid pathway from the drug container for delivery of a medicament to a target location.

The present disclosure relates to a administration assembly for a medicament delivery device, comprising: an elongated tubular delivery member cover (7), a cartridge holder (11) configured to be received by the delivery member cover (7) and configured to accommodate a medicament cartridge (31), the cartridge holder (11) having a radially flexible and radially inwards extending cartridge blocking protrusion (11b) configured to prevent the medicament cartridge (31) from moving proximally until being subjected to a proximally directed force larger than a threshold value, a needle assembly (13) comprising a double-edged needle having a proximally extending needle portion (13a) and a distally extending needle portion (13b), wherein the needle assembly (13) is configured to be assembled with the cartridge holder (11) so that the distally extending needle portion (13b) extends into the cartridge holder (11), and an administration mechanism including a plunger rod (27) configured to be proximally biased, wherein the delivery member cover (7) is configured to be linearly displaced in the distal direction relative to the cartridge holder (11), and wherein the delivery member cover (7) is configured to activate the administration mechanism when moved in the distal direction, causing the administration mechanism to move the cartridge holder (11) in the proximal direction and to subsequently move the plunger rod (27) in the proximal direction inside the cartridge holder (11) with a force larger than the threshold value.

A method of delivering epinephrine includes placing a distal end surface of a medical injector into contact with a target location of a patient. The medical injector includes a housing, an energy storage member, and a medicament container containing a dose of epinephrine effective for administration to the patient experiencing anaphylaxis and having a weight of less than 15 kg. The medicament container is coupled to a needle. The medical injector is actuated such that the energy storage member produces a force to move the needle from a first needle position to a second needle position. A distal tip of the needle extends from the distal end surface by a distance of between 7 millimeters and 8 millimeters when the needle is in the second needle position. A portion of the force is exerted to expel the dose of epinephrine when the needle is in the second position.

A fluid delivery device comprises a housing having a base including a bottom surface; a locking assembly including a cartridge receiver configured to receive a cartridge, the cartridge having a fluid reservoir and a septum configured to be generally perpendicular to the bottom surface when the cartridge is engaged with the cartridge receiver; and a needle assembly having a needle, the needle having a delivery end, a fluid coupling end, and a central portion located between the delivery end and the fluid coupling end, the needle assembly configured to move in laterally relative to the base to a first position and vertically relative to the base to a second position. The locking assembly prevents the needle assembly from moving to one or both of the first and second positions unless the cartridge is engaged with the cartridge receiver.

A drug delivery system for injecting a medicament includes a housing defining a cavity, a container received within the cavity and configured to receive a medicament, the container comprising a stopper configured to move within the container and a closure, a drive assembly received within the cavity and configured to drive the stopper within the container, a needle actuator assembly received within the cavity and comprising a needle configured to be placed in fluid communication with the container, the needle moveable from a first position and a second position spaced from the first position, and a sterilizer received within the cavity and configured to sterilize at least one of the container, the drive assembly, and the needle actuator assembly upon activation of the drug delivery system.

Methods and systems for determination of flow parameters of administered fluid from a radioembolization delivery device may include translationally moving a device delivery arm of the radioembolization delivery device in a translational direction, wherein the device delivery arm is coupled to a syringe holder such that move in the translational direction one of proximally or distally advances the syringe holder; sensing, via one or more pattern sensors, a corresponding movement of a pattern associated with the translational device delivery arm movement as a sensed pattern movement; generating, via the one or more pattern sensors, one or more output signals based on the sensed pattern movement; and generating, via a processor, a flow rate of the administered fluid, a flow amount of the administered fluid, and/or the translational direction of movement of the device delivery arm with respect to the syringe holder based on the one or more

A drug delivery device includes a housing, a needle having a retracted position and an extended position, a needle actuator body received within the housing and configured to move from a pre-use position where the needle is in the retracted position to a use position where the needle is in the extended position, a container received within the housing, with the container having a first position and a second position spaced axially from the first position, and an actuator button moveable relative to the housing from a first position to a second position to actuate the needle actuator body from the pre-use position to the use position. The actuator button includes a container holder configured to restrict movement of the container from the first position to the second position when the needle actuator body is in the pre-use position.

The present invention relates to a medicament delivery device comprising, a housing (10, 114) having a proximal and a distal end, a delivery member connected to the housing; a medicament container (84) operably arranged within the housing; a drive mechanism (102, 108) capable of acting on the medicament container (84) for priming and for expelling a dose of medicament. The invention is characterised in that the device further comprisesan activator mechanism configured to interact with the drive mechanism, such that a first interaction between the activator mechanism and the drive mechanism causes the container to move towards the delivery member wherein the container is primed and such that a subsequent second interaction between the activator mechanism and the drive mechanism causes a dose of medicament to be expelled through the delivery member.