A hard-packaged safety needle device comprises a needle hub comprising a distal portion and a proximal portion, a needle cannula extending from the distal portion of the needle hub, and a hard needle enclosure comprising a needle cover, an adapter and a cap. The needle cover is configured to house the needle cannula, and the adapter has a tapered aperture configured to create an interference fit and a sterility barrier with the tapered outer surface of the needle cover. The caps includes a distal opening defining a first cavity, the cap being configured to interdigitate with the adapter by the first cavity of the cap receiving a proximal portion of the adapter.

A syringe assembly of a pre-filled syringe that includes a syringe cap having a tubular cover member that covers a cap body. The cover member includes a substantially opaque first tubular section and a second tubular section having a display section. An inner peripheral surface of the cover member is roughened at least from a vicinity of a distal end of the first tubular section to a vicinity of a proximal end section of a proximal end tubular section.

A medical injector including a cap remover or second cap is disclosed. The medical injector includes an injector housing defining a reservoir, a plunger rod, and a stopper engaged with a portion of the plunger rod and slidably disposed within the reservoir. The stopper being sized relative to an interior of the injector housing to provide sealing engagement with a sidewall of the injector housing. The medical injector further includes a needle having a sharpened first end and a second end in communication with the reservoir, a first cap covering the sharpened first end of the needle, and a second cap covering at least a part of the first cap. The second cap is engaged with the first cap such that removal of the second cap simultaneously removes the first cap from the first end of the needle.

Device for dispensing a substance having: a dispensing element through which the substance can be dispensed, a displaceable protective element for the dispensing element, a drive element that is coupled with the protective element and a feedback element which can generate a signal when or after a predefined quantity or the entire quantity of the substance to be dispensed has been dispensed characterized in that the feedback device is coupled with the drive element.

A method for providing a passivation layer or pH protective coating on a substrate surface by PECVD is provided, the method comprising generating a plasma from a gaseous reactant comprising polymerizing gases. The lubricity, passivation, pH protective, hydrophobicity, and/or barrier properties of the passivation layer or pH protective coating are set by setting the ratio of the O.sub.2 to the organosilicon precursor in the precursor feed, and/or by setting the electric power used for generating the plasma. In particular, a passivation layer or pH protective coating made by the method is provided. Pharmaceutical packages coated by the method and the use of such packages protecting composition contained in the vessel against mechanical and/or chemical effects of the surface of the package without a passivation layer or pH protective coating material are also provided.

Provided are devices and methods for injecting viable transplant tissues into a subject. The device includes a fluid exchange chamber having a funneled portion connected to a pre-injection tube. The chamber includes fluid transfer holes and is disposed in an outer shell having a central bore connecting a top inlet and a bottom outlet from which the pre-injection tube exits the shell. A plunger having a central channel and a tapered bottom is disposed in the central bore such that the tapered bottom mates the funneled bottom when depressed and a stylet plunger is disposed in the central channel of the plunger.

An assembly for a drug delivery device is provided, the assembly comprising: a housing for receiving a reservoir, and a cap releasable with respect to the housing, wherein the assembly has a capped state and an uncapped state, wherein the cap comprises a member to be gripped by a user for releasing the cap from the housing, wherein the member is rotatable to release the cap from the housing, wherein the assembly comprises an interface to convert rotational movement of the member into axial movement of the member, the interface comprising a track configured to guide movement of the member, wherein the track has a first region and a second region, wherein, when the first region guides the movement, the member is displaced from the housing by a first distance, and when the second region guides the movement, the member is displaced from the housing by a second distance.

A cap assembly for a drug delivery device is described comprising a cap, and a clip element which is configured to be attached to the cap, the clip element comprising a first component, and a second component, wherein the first component is at least partly received by the second component, wherein the first component and the second component are firmly connected to one another, and wherein the connection between the first component and the second component is the means by which the second component is attached to the cap. Moreover, a method for assembling a cap assembly is described.

A syringe including a barrel, a plunger, and a vented closure. The barrel has a bore, and an end with an opening in communication with the bore and a barrel flange disposed outwardly of the opening. The plunger is disposed in the bore, and is movable along the bore. The vented closure is attached to the barrel at the end, and includes a stopper, a cap and a filter. The stopper is disposed over and/or in the opening in communication with the bore. The cap includes a body disposed over the stopper, and a fastener engaged with the barrel flange. The filter is disposed between the stopper and the cap, or in at least one of the stopper and the cap.

A method for providing a passivation layer or pH protective coating on a substrate surface by PECVD is provided, the method comprising generating a plasma from a gaseous reactant comprising polymerizing gases. The lubricity, passivation, pH protective, hydrophobicity, and/or barrier properties of the passivation layer or pH protective coating are set by setting the ratio of the O.sub.2 to the organosilicon precursor in the precursor feed, and/or by setting the electric power used for generating the plasma. In particular, a passivation layer or pH protective coating made by the method is provided. Pharmaceutical packages coated by the method and the use of such packages protecting composition contained in the vessel against mechanical and/or chemical effects of the surface of the package without a passivation layer or pH protective coating material are also provided.