A syringe is disclosed. The syringe comprises a plunger and a barrel. The plunger can be rotated relative to the barrel to lock, unlock and/or translate the components relative to each other.

An incremental syringe configured for displacement of fluid, such as medicaments is disclosed. The syringe may comprise detents on the syringe plunger configured to provide tactile feedback, audible feedback, or both, for discrete units of fluid aspirated or injected to or from the syringe. In some embodiments, a second set of detents is included, and in some embodiments a third set of detents is included.

Apparatus and methods for medicament delivery. The apparatus may include, and the methods may involve, a delivery device for delivering a target amount of the medicament from a distal end of the device. The device may include a rod for moving a plunger that discharges the medicament from the distal end. The device may avoid or reduce deformation of the plunger during the discharge. The plunger motion may be stopped by detent that interacts with the rod. The apparatus and the methods may provide an operator indication of progress of stages of operation. The device may feature triggers corresponding to stages of medicament displacement from the device, such as pre-delivery stages, including priming.

A substance delivery device (autoinjector) for use with a container (such as a syringe) containing the substance includes: a body arranged to house or hold the container; a plunger which is movable with respect to at least a portion of the body, the plunger being arranged to act upon the container so as to move the container with respect to the portion of the body; wherein the plunger is also arranged to expel at least a portion of the substance from the container; and wherein the device includes elements for adjusting the amount of substance to be expelled from the container. The device can also have elements for priming the container, and can accommodate containers of different size or shape.

A retractable needle assembly includes a housing having a sidewall defining a hollow bore, and an elongate plunger, the distal end of the plunger forming a reservoir within the hollow bore for containing a fluid therein. The plunger is adapted for slideable movement within the hollow bore. The assembly includes a hub disposed within the hollow bore and at least partially supporting a cannula therewith, and a needle retraction member engaged with the hub for manually selectable advancement with respect to a portion of the housing. The needle retraction member may be advanced from an initial position in which at least a portion of the needle is disposed outside the housing, to a retracted position in which the needle is fully surrounded by the housing. The elongate plunger may be advanced about the hub for extracting the fluid into the reservoir or expelling the fluid from the reservoir.

Disclosed are systems that include a syringe having a barrel configured to hold a fluid and a plunger configured to draw the fluid into the barrel when the plunger is pulled backward through the barrel. The syringe is configured to inhibit forward movement of the plunger. For example, the systems can include mating pockets configured to engage barbs to inhibit forward movement of the plunger.

An injector comprises a cylindrical barrel, a movable body housed in the barrel, and a plunger coming into separable contact with the movable body. The movable body includes a main body having an outer diameter smaller than an inner diameter of the barrel, a disk-shaped seal body disposed on the main body and including an outer circumferential end brought into close contact with an inner circumferential surface of the barrel, and at least one projecting portion projecting from the main body toward the inner circumferential surface of the barrel. A distance from a central axis of the movable body to a leading end of the at least one projecting portion is smaller than a half of an outer diameter of the seal body.

An apparatus includes a housing, a medicament container, an actuator, and a biasing member. The actuator is configured to move the medicament container within the housing when the actuator is moved from a first configuration to a second configuration. The actuator includes a gas container and a puncturer. When the actuator is in the first configuration, a portion of the puncturer is disposed apart from the gas container. When the actuator is in the second configuration, the portion of the puncturer is disposed within the gas container. The gas container has a longitudinal axis offset from a longitudinal axis of the medicament container. The biasing member is configured to bias the actuator toward the second configuration.

Disclosed herein are devices and methods for delivering a predetermined volume of a drug substance or other product including a fluid. An exemplary device may include a body configured to receive a drug substance therein, and a plunger rod disposed at least partially inside the body to distally move a stopper in the body. The device may include a component configured to regulate distal movement of the plunger rod in a priming step and in a subsequent delivery step, so that the device may be accurately primed and may accurately dispense a predetermined volume of a drug substance.

The present disclosure is generally directed to a drive mechanism for use in a drug delivery device having a cylindrical cartridge, i.e. a handheld injection device for selecting and dispensing a number of user variable doses of a medicament. The drive mechanism includes a base element, a toothed piston rod, which is guided within and movable relative to the base portion, and a drive gear having a pinion, which is rotatably held in the base element and in meshed engagement with the toothed piston rod. The toothed piston rod includes multiple rigid rod pieces which are connected by hinges. The rigid rod pieces comprise a flat plate provided with a straight toothed rack.