The present invention provides a drug composition comprising particles comprising a biodegradable or bioerodable polymer and a drug, a soluble, biodegradable or bioerodible excipient, a bulking agent and a reconstitution aid. The invention also provides a pharmaceutical formulation and a unit dosage form of the pharmaceutical formulation. The invention provides methods of treatment of a disease or condition accordingly. The invention also provides a drug composition for use in a cannulation device.

A stopper retainer comprises a base having an upper surface, a lower surface, and a perimeter; a sidewall joined to the base around the perimeter, the sidewall having a raised height to define an interior cavity with the base; and a plurality of projections extending from the lower surface of the base, each of the plurality of projections being sized to at least partially fit within a lumen of a syringe barrel.

An exchangeable cartridge for an injection device is disclosed. The cartridge (3) comprises a container (4) and a plunger (10) connectable with a plunger rod (9). The container receives the plunger rod from its rear end. The plunger comprises a rod connector (12) connectable with a front portion (13), and the rod connector has a base portion (24), an outer wall section (15), an inner wall section (16), and a rod stop portion (17) encircled by the inner wall section. The inner wall section comprises several tongues (22) protruding rearwards from the base portion and defining an entrance opening (18) for the plunger rod. The inner wall section receives a front portion (13) of the plunger rod through the entrance, and the tongues are provided with retaining portions arranged to retain the front end portion during retraction of the plunger rod within the housing.

A device for administering a fluid can include a cylinder, a piston connected to a piston rod, and a tensioning device connected to the piston rod. The tensioning device includes a ramp which is rotatable via a motor, a ramp track, and a roller. A dose setting means can be provided which comprises a spacer and a movement unit. The spacer moves from a neutral position into an active position such that the driver is stopped by the spacer so the piston stroke during the movement of the piston to the open dispensing end is shorter in comparison to the case in which the spacer is in its neutral position. The spacer has a through bore in which a spindle with a spindle thread is guided. A pin protrudes into the spindle thread. The spindle thread leads at at least one of its two ends into an annular groove.

An injection system and apparatus comprises a housing with a loading tray configured to accept a medication cartridge, a needle configured to transport medication from the medication cartridge to an injection site, a retractable sheath formed on an injection end of the housing, and a telescoping plunger comprising at least two telescoping sections, wherein the plunger is configured to impart downward force on the medication cartridge in order to release medication in the medication cartridge through the needle to an injection site.

A syringe assembly includes a substantially cylindrical syringe barrel including a fluid dispensing end, an open end, and at least one protrusion adjacent the open end, the at least one protrusion projecting inwardly from an inner surface of the syringe barrel, a stopper configured to be received within the open end of the syringe barrel, and a plunger rod having a plunger rod body extending along a longitudinal axis from a proximal end to a distal end and at least one support disk provided on the distal end thereof. The support disk on the plunger rod is configured to bear against the protrusion of the syringe barrel upon misalignment of the plunger rod in the syringe barrel.

A plunger assembly (100) for use with an auto-injector and comprising: a cartridge (102); and a firing assembly (103) comprising a plunger rod (104) and a drive portion (105), the firing assembly (103) being axially moveable relative to the cartridge (102), wherein the firing assembly (103) is configured to couple to the cartridge (102) at a coupling point along a length of the cartridge (102) to fix an axial position of the drive portion (105) relative to the cartridge (102), and wherein the length of the cartridge (102) is configured to be extended in a rearward direction such that the coupling point and a forward end (106) of the plunger rod (104) move rearwards.

A torque-limiting device comprises a plunger rod holder defining a piston cavity for receiving at least a portion of a plunger rod, a moveable stop element, a dowel disposed adjacent the stop element, a spring disposed adjacent the dowel, and a syringe barrel holder defining a barrel cavity for receiving at least a portion of a syringe barrel.

Systems, devices, and methods for a syringe holder. A system embodiment may include: a base platform defining a syringe flange opening and a set of adjustment openings, a latch assembly movably attached to the base platform, the latch assembly comprising an adjustment screw threaded between the base platform and the latch assembly, and a guidepost oriented parallel to the adjustment screw, wherein the guidepost is threaded between the base platform and the latch assembly, a valve assembly attached to the base platform, and a hose attached to the base platform.

A plunger for use with a syringe has a plunger body with a proximal end, a distal end, and a circumferential sidewall extending between the proximal end and the distal end along a plunger longitudinal axis. The plunger further has at least one resiliently deflectable retaining member having a first segment attached to the plunger body and a second segment protruding toward the distal end of the plunger body and deflectable relative to the first segment. The plunger further has at least one actuation member associated with the at least one resiliently deflectable retaining member. The at least one actuation member interacts with a piston to deflect the at least one resiliently deflectable retaining member upon rotation of the plunger relative to the piston. The plunger is engageable with the piston regardless of a rotational orientation of the piston relative to the plunger.