An engagement mechanism associated with a reciprocally movable piston of a fluid injector is configured for releasably engaging an engagement portion at a proximal end of a rolling diaphragm syringe having a flexible sidewall configured for rolling upon itself when acted upon by the piston. The engagement mechanism has a plurality of engagement elements reversibly and pivotally movable about a pivot pin relative to the engagement portion of the syringe between a first position, where the plurality of engagement elements are disengaged from the engagement portion of the syringe, and a second position, where the plurality of engagement elements are pivotally movable about the pivot pin in a radially inward direction to engage with the engagement portion of the syringe. The engagement mechanism further has a drive mechanism for moving the plurality of engagement elements between the first position and the second position.

Provided herein is a system for homogeneous injection of medicine including a device for homogeneous injection of medicine, which may include a cylinder holding part having a cylinder of a syringe held therein, a plunger resting part being configured to be independent from the cylinder holding part and having an end of the plunger of the syringe rest therein, first and second pressurized lead screw supporting parts each being provided on one side of the cylinder holding part and one side of the plunger resting part, respectively, and being connected to a pressurized lead screw being provided with a screw thread, and a motor being connected to one side of the first pressurized lead screw supporting part so as to rotate the pressurized lead screw; and a monitoring unit monitoring injection dosage and having one side connected to a needle of the syringe or a medicine outlet of the syringe cylinder and having its opposite side connected to a tube providing medicine to a patient, thereby monitoring physical quantities related to the injection of the medicine.

A fat suction and graft syringe includes a negative pressure adjustment mechanism. The negative pressure state in a barrel can be maintained during a procedure only by pulling and releasing a plunger, and only by slightly rotating the plunger. The plunger can be pushed inside the barrel without being constrained by a multi-level holding plate and a single-surface rotation clip, whereby the syringe has enhanced convenience in the use and production thereof so that many practitioners accustomed to using a normal syringe can easily use the syringe without separately learning how to manipulate the syringe.

A dosage sensing module for or in a pen drug delivery device and comprising a power source unit, a processor unit and a dosage sensor unit with a first sensor part adapted to be fixed to a part not rotating during dose expelling and comprising a flexible printed circuit board sheet on which a pattern of individual electrical conductive sensor areas are arranged. The sensor unit further comprises a second sensor part adapted to be fixed to the piston rod to follow the rotation thereof during dose expelling. The second sensor part comprises individual structures that together with the conductive sensor areas are adapted to, upon relative rotational movement between the first and second sensor part, provide electrical signals to a processor unit indicative of the relative rotational position between the first and second sensor part.

A plunger rod (104) for use in connection with a syringe barrel (102) is provided. The plunger rod (104) comprises a distal plunger top (105), having a proximal bottom surface (113), and a proximal elongated shaft (106) comprising a proximal end (107a) adapted to receive an applied force along an axis (1000) and a distal end plate (107b) adapted to transmit said applied force along said axis (1000). The plunger rod (104) is adapted to be inserted into the barrel (102) of a syringe (100) extending along the axis (1000). The distal plunger top (105) and the proximal elongated shaft (106) are connected to each other by a releasable connection (115). The releasable connection (115) comprises: distal top rupture means (116) comprising at least one distal top rib (125a) disposed eccentrically from the axis (1000) on the proximal bottom surface (113), and proximal shaft rupture means (117) comprising at least one proximal shaft rib (125b) disposed eccentrically from the axis (1000) on the distal end plate (107b). Each said at least one distal top rib (125a) is connected to a corresponding at least one proximal shaft rib (125b), said ribs (125a, 125b) being connected at a contact area (118), and wherein said distal top rupture means (116) is configured to detach from the proximal shaft rupture means (117) due to compression failure when the distal plunger top (105) is pushed into a distal end (110) of the barrel (102). A syringe is also provided.

A device (100) having a proximal end (20) and end a distal end (40) for withdrawal of a liquid sample, fractionation, and separation of one or more fractions comprising: a piston assembly (300) comprising a piston (302) dismountably attached at its proximal end (20) to an actuating rod (350); a container (200) having a body (202) disposed with a cylindrical chamber (204) for slidable movement of the piston (302) therein; wherein the cylindrical chamber (204) is provided at the distal end (40) with a resealable septum (410) for co-operation with a puncture needle assembly (600) for withdrawal of the liquid sample, an at the proximal end (20) with a stop member (206), which stop member (206) limits movement of the piston (300) in a proximal direction, wherein the container body (202) is dimensioned to fit inside a centrifuge rotor, and is configured for breakability into two parts at a temperature of 0 deg C. or lower at a breakable zone (210).

A device for administering a fluid can include a cylinder, a piston connected to a piston rod, and a tensioning device connected to the piston rod. The tensioning device includes a ramp which is rotatable via a motor, a ramp track, and a roller which is in contact with the ramp track and which is mounted rotatably in a driver. The device can further include a front part, which includes the cylinder and the open dispensing end, and a rear part, which includes the tensioning device. The front part and the rear part can be formed from different materials.

A medicine injection pen includes a body, a drive member within the body and configured to move relative thereto upon actuation, a cartridge housing releasably engageable with the body and configured to retain a medicine cartridge, at least one sensor, and at least one detector. The medicine cartridge has a liquid medicine therein and includes a piston configured to slide therein. The drive member is configured to move relative to the body to urge the piston to slide within the medicine cartridge to dispense at least some of the liquid medicine from the medicine cartridge. The sensor(s) is configured to sense movement of the drive member relative to the body to enable determination of an amount of the liquid medicine dispensed. The detector(s) is configured to detect a gap between the drive member and the piston.

A syringe system includes a syringe and a pressurization device for a syringe. The pressurization device for a syringe is configured so that the plunger advances by a forward rotation of the plunger, and the plunger retracts by a reverse rotation of the plunger. The plunger is advanceable by pressing the gasket at the time of the forward rotation and is retractable with respect to the barrel without pulling the gasket in the proximal end direction at the time of the reverse rotation.

A device for positioning a needle tip to a desired location by signaling pressure change is provided. The device includes a barrel, a piston, a biasing element, and a plunger. The barrel defines a reservoir, and it includes a distal end connectable to a puncturing apparatus. The plunger is slidably engaged with the piston, and both are movable within the reservoir. The biasing element connects the plunger and the piston, and its change in length corresponds to the relative position of the plunger and piston. In operation, the piston is at a first position relative to the plunger when the biasing element is at a first length. The piston later moves to a second relative position in response to the biasing element's change of the length resulting from a pressure change inside the reservoir when the puncturing apparatus reaches a location of a mass. The position's change of the piston is visually detectable.