An automatic injection device with flow regulation. The automatic injection device has an insertion needle configured to be inserted into a patient and a drug container which contains a pharmaceutical product and includes a plunger. The automatic injection device also has a fluid path which fluidly connects the drug container to the patient via an insertion needle, a potential energy source, and a regulator configured to restrict release of potential energy and restrict linear movement of the plunger and the pharmaceutical product into the fluid path at a proscribed pace. The regulator includes a clock escapement mechanism and a wire and pulley system including a wire coupled to at least one pulley. The potential energy source may be a spring that surrounds the drug container and may be directly coupled to the plunger and the wire such that movement of the spring and the wire is restricted over time.

A drug injection device is disclosed. A drug injection device, according to the present invention, comprises: an injection unit which is provided with an ampoule accommodation portion for accommodating an ampoule that contains an injectable solution, and injects the injectable solution into a person being operated on; and an injection speed adjustment unit which is connected to the injection unit, applies pressure to the injectable solution, and adjusts the injection speed of the injectable solution, being injected into the body of the person being operated on, by selectively adjusting the speed of the pressure applied to the injectable solution, wherein the injection speed adjustment unit comprises: an injection unit attachment portion to which the ampoule accommodation portion is detachably attached; a pressurizing plunger which is connected to the ampoule accommodated in the ampoule accommodation portion and applies pressure to the injectable solution; and a pressurizing plunger up/down driving module which is provided on the same axis as the pressurizing plunger and drives the pressurizing plunger up or down.

A method of assembling a drug delivery device, comprising the steps of: inserting a piston rod in a nut portion of a cartridge assembly and rotating the piston rod until the piston rod distal end engages the cartridge piston, mounting a drive member on the piston rod in a rota-tional position being closest to a pre-determined rotational position, and rotating the drive member to the pre-determined rotational position.

Syringe assemblies are described herein. A syringe assembly includes an assembly housing, a first syringe, a second syringe, and a connecting gear. The first syringe is disposed within the assembly housing. Each plunger is movable within the respective syringe cavity and defines a respective chamber in the respective syringe cavity, wherein the respective chamber is in fluid communication with the respective syringe port, the respective plunger comprising a respective gear rack extending longitudinally along the respective plunger. The connecting gear is rotatably coupled to the assembly housing. The connecting gear is configured to be in meshed engagement with at least one of the first gear rack and the second gear rack of the syringes.

An automatic injection device with flow regulation is disclosed. The automatic injection device has an insertion needle configured to be inserted into a patient and a drug container which contains a pharmaceutical product and includes a plunger. The automatic injection device also has a fluid path which fluidly connects the drug container to the patient via the insertion needle, a potential energy source, and a regulator configured to restrict release of potential energy and restrict linear movement of the plunger and the pharmaceutical product into the fluid path at a proscribed pace. The regulator includes a clock escapement mechanism. The potential energy source may be a spring that surrounds the drug container and may be magnetically coupled to the plunger. The clock escapement mechanism is configured to control the spring at a regulated rate over a time interval using a gearbox and a rotational-to-linear translator comprising a rack and a pinion.

A drug injection control device has a structure in which a rod lock screw-coupled to a piston rod can make a linear motion under restricted rotation within a rod holder with the rotation of a rod guide and the sub-linear motion of the piston rod. When the injection amount of drug is preset through an injection amount setting module to make a rotational motion with a dose dial in a housing to set the amount of drug to be injected by storing the twisting moment in a torsion spring, in actuating a drug delivery module switchably coupled to the injection amount setting module, the rod lock can make a linear motion by the sliding motion of a lock protrusion through a lock guide formed through the rod holder along the lengthwise direction on the rotation of the rod guide and the sub-linear motion of the piston rod.

The present invention provides a sensor module (50) adapted to be arranged in a cartridge based drug delivery device between a rotatable piston rod and a cartridge piston. The sensor module (50) comprises a first sensor structure (52, 152, 252, 352) adapted to be at least substantially rotationally locked with respect to the cartridge piston and comprising a transversal sensor surface (52.2, 152.2, 252.2, 352.2), and a second sensor structure (53, 153, 253, 353) adapted to be rotationally locked with respect to the piston rod and comprising one or more flexibly supported and axially deflectable contact members (53.1, 53.2, 153.2, 253.2, 353.1, 353.2), which are positioned distally of the transversal sensor surface (52.2, 152.2, 252.2, 352.2) and are adapted to apply a proximally directed force thereto. The first sensor structure (52, 152, 252, 352) and the second sensor structure (53, 153, 253, 353) are adapted to undergo relative rotational motion, whereby the one or more contact members (53.1, 53.2, 153.2, 253.2, 353.1, 353.2) sweep the transversal sensor surface (52.2, 152.2, 252.2, 352.2). A processor (52.5, 152.5, 252.5) determines a relative angular displacement between the first sensor structure (52, 152, 252, 352) and the second sensor structure (53, 153, 253, 353) from signals generated as the one or more contact members (53.1, 53.2, 153.2, 253.2, 353.1, 353.2) sweep the transversal sensor surface (52.2, 152.2, 252.2, 352.2).

The invention relates to a pre-filled injection device with a non-removable cartridge wherein the drive mechanics comprises a threaded piston rod which is moved helically in a nut secured to a housing structure. During assembly of the injection device it is possible to rotate the nut member to thereby advance the piston rod into a position eliminating any air-gap otherwise occurring between the piston rod and the plunger inside the cartridge

A reusable safety syringe training device is provided. The device comprises a syringe contained within a syringe protective member. The syringe protective member is movable vertically within an outer protective sheath from a first position to a second position and back to the first position. In the first position, the device is in an injection-ready position with the needle exposed and the syringe protective member in a locked vertical position with respect to the outer protective sheath. In the second position, the device is in a post-injection position such that the syringe protective member is no longer vertically locked with respect to the outer protective sheath and has moved vertically upward thereby rendering the needle within the outer protective sheath. The plunger carries a release flange sufficient to engage release latches that otherwise retain the syringe protective member in the first position. The release flange engages that release latches when the user pushes the plunger down to effectuate the injection. Once pressure is removed from the plunger after the injection has concluded, a springe mechanism drives the syringe protective member upwards to the second position. The user can then turn the plunger such that the release flange is no longer able to engage the release latches and push the plunger back down to lock the syringe protective member in its first position. The user is then able to pull the plunger back up while the syringe protective member remains locked, turn the plunger back to a position where the release flange is in a position to engage the release latches again, and perform another injection.

Systems and methods for delayed delivery of a drug are disclosed. A drug delivery system may include a delivery member for insertion into a patient and a reservoir configured to receive a volume of a drug. An energy source may be activatable by the patient to actuate the reservoir to deliver the drug to the patient as a single bolus. A lockout system may be configured to have a locked state, wherein the lockout system prevents movement of the delivery member and/or activation of the energy source, and an unlocked state, wherein the lockout system permits movement of the delivery member and/or activation of the energy source. The lockout system may be configured to automatically change from the locked state to the unlocked state after a preselected time period has elapsed. An output element may generate a detectable output after the preselected time period has elapsed for notifying the patient.