A needle and syringe system that provides ultra-low dosage waste and automatic needlestick protection. A syringe assembly is provided that contains a barrel and a plunger. A tubular spacer is disposed in the barrel. A needle head assembly is provided that includes a collar and a needle. A safety slide is positioned between the needle and the collar. The safety slide has a sheathing tube that surrounds part of the needle. The safety slide can move relative the needle. In a first position, the sheathing tube does not extend beyond the sharpened end of the needle. In a second position, the sheathing tube extends beyond the sharpened end of the needle. When advanced, the plunger head moves the tubular spacer. The tubular spacer passes over the base of the needle and presses against the safety slide. The safety slide is moved from the first position to the second position.

A needle and pre-filled syringe system that provides ultra-low dosage waste and automatic needlestick protection. A syringe assembly is pre-filled with an injection material. A needle head assembly attaches to the syringe assembly. A spacer is disposed between the needle head assembly and the syringe assembly. The spacer has a central opening. The needle head assembly supports a needle with a needle base. When assembled, the needle base passed into the central opening of the spacer. The needle head assembly also contains a safety slide that can selectively cover the needle. During an injection, pressure and/or contact with the plunger head causes the spacer to contact and move the safety slide. The safety slide moves to cover the needle during the injection procedure, therein rendering the needle safe before the injection process is even complete.

Examples include a medicament delivery device including a housing, a medicament delivery member assembly configured to be moved from an initial position to a penetration position and from the penetration position back to the initial position, a penetration and withdrawal mechanism, an activation mechanism, and a stop mechanism, where the penetration and withdrawal mechanism includes a driver operably connected to the medicament delivery member assembly and to the activation and stop mechanism, a drive element operably connected to the driver, a biased force element connected to the drive element, and a switching element arranged between the driver and the drive element, where operation of the stop mechanism allows the biased force element to interact with the drive element, causing movement of the switching element such that the driver is moved in an opposite direction and moves the medicament delivery member assembly back to the initial position.

A syringe cartridge comprising a reservoir part and an extension extending from said reservoir part, said extension defining a fluid path and comprising a molding and a first needle extending from said molding, the extension turning to a finite angle with respect to an axis of said reservoir part and wherein at least part of said first needle is likewise at said finite angle, at least some of said part of said first needle at said finite angle being enclosed within said molding of said fluid path.

A drug delivery device may be used with the cartridge and includes a skin-contacting surface. In use the longitudinal axis of the interior of the cartridge may be disposed substantially parallel to the skin-contacting surface.

A stopper includes a main body portion defining an open rearward end configured to receive the plunger rod, an engagement portion provided along an inner circumference of the main body portion configured to engage at least a top portion of the plunger rod, a closed front end forming a flexible roof, and a first perimetrical skirt extending around an outer circumference of the main body portion toward the closed front end of the main body portion. When fluid pressure is increased inside the syringe barrel during an injection, the flexible roof expands in a radial direction toward an inner wall of the syringe barrel, the first perimetrical skirt is forced against the inner wall of the syringe barrel, and an engagement between the plunger rod and the engagement portion forces the main body portion to expand in the radial direction toward the inner wall of the syringe barrel.

Drug delivery systems with reduced hold-up volumes are provided. The drug delivery systems include a cartridge configured to hold a liquid drug. A cartridge stopper is positioned in a first portion of the cartridge. A needle guide component is positioned within the cartridge stopper. A needle is positioned within a central opening of the needle guide. A plunger is positioned in a second portion of the cartridge. The plunger includes a fluid path pocket facing and aligned with the central opening of the needle guide component. The plunger is driven toward the cartridge stopper to expel the liquid drug from the cartridge through the needle. An end of the needle can be positioned within the fluid path pocket when the plunger is pushed against the cartridge stopper, ensuring that only a small volume of the liquid drug remains in the cartridge when delivery of the liquid drug is completed.

A reduced profile syringe assembly is provided that includes an overall profile that is substantially similar to a profile of a syringe barrel. The syringe assembly includes a plunger rod that is significantly disposed within the syringe barrel when filled for use, with the plunger rod adapted to be retracted from the syringe barrel during dispensing of contents of the syringe barrel.

A drug delivery device may include sterile needle covered by removable a sterility preserving protector. The device optionally includes skin contact surface and a needle protector for preventing a stick hazard upon removal of the skin contact surface from an injection site or angle without Removing completely. Optionally, the needle protector may include a shield that interferes with replacement of the needle protector. In some embodiments, the needle cover may interfere with deployment of the needle protector.

A discharger includes a dispensing element and a housing. The housing has a static piston connected to the dispensing element at least in a fluid conducting manner. The static piston has a piercing tip and is arranged within the housing.

A trigger operated syringe (100) for intramammary injection of antibiotics has a fluid containing syringe cartridge (203) activated by a plunger (206) which is inserted into the syringe cartridge (203A) and expels fluid when the trigger (205) is pulled. A syringe cartridge holding mechanism (223) holds the syringe cartridge in place until the trigger (205) is released and the plunger (206) retracted. Single syringe cartridge (203) and multiple syringe cartridge (204) versions are disclosed. The plunger moves in a direction which is effectively perpendicular to the direction of movement of the trigger, allowing for ease of injection to a cow's teats, and ejection of the spent cartridges.