A pre-filled drug delivery device, comprising a housing, a drug container within the housing and containing a drug; a plunger held within the drug container, movement of the plunger within the drug container being operative to dispense the drug from the drug container through an outlet; and a drive mechanism within the housing including a stored energy source and a plunger rod held in locked position against the stored energy source prior to activation of the device, wherein on activation of the device the stored energy source moves the plunger rod such that the plunger rod moves the plunger within the housing wherein the plunger rod comprises a longitudinal shaft formed from sheet metal, wherein the sheet metal defines a plane, and wherein the sheet metal is deformed so that the longitudinal shaft comprises an out-of-plane engagement surface, the out-of-plane engagement surface configured to engage a retaining surface on the housing or on a component of the drive mechanism, to hold the plunger rod in the locked position.

A dual chamber syringe facilitates selective drug mixing, dosing, and administration, as well as pre- or post-administration flushing with a single syringe instrument. A syringe barrel incorporates an outlet, as well as variable-volume, primary and secondary fluid chambers, separated by a floating stopper. The floating stopper defines a dome-shaped split septum with a central slit at its apex. The split septum is a bi-stable valve, closing the central slit by compression in its meridial dimension when the septum is in a first, relaxed state, and opening the central slit when the septum is buckled or flipped under tension in the meridial dimension in a second state. Buckling of the septum wall is caused solely by differential fluid pressure applied by a single plunger, without physical contact of the septum with any other structure within the syringe.

A plunger rod for use in a syringe barrel for driving a bung through the syringe barrel to expel a substance therefrom, the plunger rod including: a bung fixing configured to be received within a recess of a bung and including at least one laterally extending lug including a thread engagement surface configured to engage with a point on a track portion of a thread on a sidewall of the recess, wherein the lug is further configured to cross the thread on relative rotation between the plunger rod and the bung under a force applied by a user, such that the thread engagement surface of the lug engages the point of the track portion every full rotation of the syringe plunger relative to the bung.

A plurality of embodiments of mixing syringes are provided. Inventive key to all of the embodiments is a piston valve which divides a barrel to create a pair of chambers in which matter and liquid can be disparately and securely disposed before mixing. Each disclosed piston valve is actuated by force on an associated plunger rod which produces pressure within an associated syringe resulting in a change of the valve state from closed to open. In addition, each such valve comprises check valve action which is permissive to only distal flow through the syringe. Embodiments for both a basic mixing syringe and a mixing syringe with flush are disclosed. Considerations and methods for chamber filling without valve actuation are provided. A mixing syringe system with flush system utilizing a dual chamber syringe having a male luer fitting and a separate diluent containing vessel having a female luer fitting is also disclosed. In addition, a valve piston which comprises a proximally disposed skirt for providing an additional seal when the valve piston momentarily cants is disclosed. Further a valve piston, which comprises a plurality of rings, at least one of which is forced to further radially displace by a positive pressure differential applied against one of two opposing convex piston faces to thereby increase a seal between barrel wall and piston is disclosed.

A syringe system and components thereof are disclosed. The system may include a syringe body having a hollow lumen, a proximal open end, and a distal end. The syringe body may be configured to house a fluid therein. The syringe system may further include a plunger positioned in the hollow lumen of the syringe body, forming a seal with an inner wall of the syringe body. The plunger may include a removable piston having a shaft extending from the distal end towards the proximal open end, a stopper removably connected to a distal portion of the shaft, and at least one coupler attached to the distal portion of the shaft. The stopper may be configured to slidably move within the hollow lumen to facilitate movement of the fluid within the syringe body. The coupler may be configured to facilitate removal and attachment of the stopper from the piston.

There is provided drug delivery devices comprising a drug container assembly with a needle and automatic needle insertion and drug delivery mechanisms. Aspects of the devices described include a noise-generation mechanism to indicate the completion of drug delivery, a mechanism for triggering drug delivery following needle insertion, front-end activation of the device and a safety mechanism for covering the needle after use and methods of assembly of the devices.

There is provided drug delivery devices including a drug container assembly with a needle and automatic needle insertion and drug delivery mechanisms. Aspects of the devices described include a noise-generation mechanism to indicate the completion of drug delivery, a mechanism for triggering drug delivery following needle insertion, front-end activation of the device and a safety mechanism for covering the needle after use and methods of assembly of the devices.

A stopper adapted for attachment with a plunger rod for use within a syringe barrel is disclosed. The stopper includes a main body defining an open rearward end and a closed front end. The open rearward end is adapted to receive a front forward end attachment portion of the plunger rod. The stopper also includes a core member integrally formed with the main body adjacent the closed front end. The core member includes a nose portion having a conical tip configured for entering an outlet opening of the syringe barrel. The closed front end of the stopper has a profile configured to cooperate with an internal surface of the syringe barrel wall to prevent reflux and reduce dead space within the barrel.

A stopper for use within a medicament container, preferably a plastic container, is presented having a main body defining an open distal end and a closed proximal end, where the main body has a longitudinal axis L. A cup shaped tip portion is integrally formed with the main body adjacent the closed proximal end and a distally extending flexible skirt extends from a distal end outer surface of the main body, where the distally extending flexible skirt has a rib which extends radially outward around a perimeter of the distally extending flexible skirt. A proximally extending flexible skirt extends from a proximal end outer surface of the main body, where the proximally extending flexible skirt has at least two ribs which extend radially outward around a perimeter of the proximally extending flexible skirt and that are axially spaced apart along the proximally extending flexible skirt.

A method of manufacturing a sealing element for use in a fluid conveyance device comprising the steps of: forming an elastomeric sealing body including a first body portion defining at least one annular sealing rib, and a second body portion arranged on an end of the first body portion, the second body portion comprising an annular protrusion extending radially beyond the first body portion; and forming a layer of barrier material on a free end of the second body portion, wherein the forming steps are carried out in a single molding operation.