A system for serially injecting liquids includes a syringe body defining a syringe proximal opening and a distal needle interface, proximal and distal stopper members, forming proximal and distal chambers. The system also includes a first liquid in the distal chamber and a second liquid in the proximal chamber, and a plunger configured to be manually manipulated to insert the proximal stopper member distally. Moreover, the system includes a needle hub assembly coupled to the syringe body, the needle assembly including a needle. The needle defines a needle interior, and distal, middle and proximal openings. The distal, middle and proximal openings are fluidly coupled through the needle interior. Manipulating the plunger member to insert the proximal stopper member initially expels the first liquid from the distal chamber, then serially expels the second liquid from the proximal chamber.

A dual-needle syringe capable of preventing infection, including: an infusion needle shaft (3) configured to aspirate a liquid from a drug container (30); an injection needle shaft (5) having a sharp point of one end inserted into a body, and the other end connected to the syringe (10), through which the liquid filled in the syringe (10) is injected into a body; a hub barrel (7) engaged to a barrel (15) of the syringe (10) to infuse the liquid, which is aspirated from the drug container (30) through the infusion needle shaft (3), into the syringe (10) through the injection needle shaft (5), the hub barrel having an infusion needle shaft hub (21) and an injection needle shaft hub (23) which can be separated from each other before the liquid is injected; and a filter (9) configured to filter foreign substances contained in the liquid.

An approach is provided for delivering therapeutic materials to an intervertebral disc via a sub-ligamentous space. The approach includes positioning a tool at an interface of a longitudinal ligament and an outer surface of the intervertebral disc, in which the interface is the sub-ligamentous space. The tool may include a first needle and a second needle housed within the first needle. An insertion end of the first needle may include a shallow beveled end. The approach includes inserting the insertion end of the first needle into the sub-ligamentous space. The approach includes deploying the second needle from within the first needle into at least one of an annulus and a nucleus of the intervertebral disc. The approach includes delivering the therapeutic materials to the at least one of the annulus and the nucleus.

The present invention is an auto-injector for the administration and self-administration of drugs by subcutaneous, intramuscular or intra-dermal injection and for drug solutions or suspensions. The auto-injector may comprise three modules for ease of assembly, the modules principally including a standard cartridge module with stopper and septum, a power source and indicator module that pushes against the cartridge stopper pressurizing contents, an injection progress indicator and a needle shuttle comprising of two needles, one needle being the injection needle and one needle being the septum needle. A needle guard ensures that the needle is always covered thus hiding the needle before and after the injection and that prevents needle stick injurie.

A delivery system for delivering a drug depot to a site within a patient, the system comprising: a cannula; a delivery stylet configured and dimensioned to be receivable by and slidable forwardly and backwardly within the cannula including to a position wherein a distal portion of the stylet protrudes beyond the distal end of the cannula; a drug depot retainable by the stylet at the distal end of the stylet, the drug depot being visualizable by a diagnostic imaging beam or modality; and an actuator for ejecting the drug depot from the stylet to a site within the body using fluid pressure. Also disclosed are methods using, and uses of, the delivery system, including for treating scoliosis.

An injector may include a container having a wall with an interior surface defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a sterile container needle that is in fluid communication with the container in a delivery state, but may or may not be in fluid communication with the container in a storage state. Further, the injector may include an actuator that is adapted to move the container needle from the storage state to the delivery state.

An indwelling needle for subcutaneous administration configured to be indwelled in subcutaneous tissue for subcutaneously administering a medicinal solution includes an inner needle including an inner needle main body at a distal end of which a sharp needle tip is formed, and an inner needle hub on a proximal end side of the inner needle main body, and an outer needle including an outer needle main body having a lumen through which the inner needle is inserted, and an outer needle hub on a proximal end side of the outer needle main body in which a hub insertion portion in which the inner needle hub is mounted is formed. The needle tip of the inner needle protrudes 2.5 to 9 mm in an axial direction from a distal end of the outer needle in a state in which the inner needle hub is mounted in the outer needle hub.

A transfer device for living organisms is used for placing an object in a living organism. The transfer device for living organisms includes a tubular needle extending in one direction, and a pushing member located inside the needle. The needle is configured to capture an object therein from an opening at a tip of the needle. The pushing member is configured to be movable relative to the needle from inside the needle toward the opening.

A microneedle injection and infusion apparatus, and a method of using same. The apparatus can include a housing, a microneedle array holder for holding a microneedle array, and a shuttle that holds a cartridge (e.g., that contains an active agent). The microneedle array holder can be movable between a retracted position and an extended position. The shuttle can be movable between a first position in which the cartridge is not in fluid communication with a fluid path and a second position in which the cartridge is in fluid communication with the fluid path. The apparatus can further include an actuator movable between a first position and a second position. The method can include moving the actuator to its second position to allow the shuttle to move toward its second position, wherein movement of the shuttle toward its second position allows the microneedle array holder to move to its extended position.

A two piece adapter for extrusion of cylindrical core-shell structures using conventional biomedical needles includes first and second adapter pieces. The first adapter piece includes first and second (core and shell) inlet ports. The core inlet port leads directly to a male Luer fitting attachable to a core needle and surrounded by a threaded chamber. The shell inlet port is led, via a side chamber, into the side of the threaded chamber. The second adapter piece attaches to the bottom of the threaded chamber and is configured to attach to a shell needle, so that the shaft of the core needle sits inside the shaft of the shell needle.