Provided is a system and method for an anti-foaming needle assembly for avoiding foam generation when extracting a liquid from a vessel having a chamber with a bottom and opposite thereto an opening sealed with a penetrable and re-sealable stopper providing an inner surface above the chamber. More specifically, the anti-foaming needle assembly includes a needle base having: a first end and opposite thereto a second end and a sidewall there between, the second end structured and arranged for temporary connection to a syringe having a barrel and a plunger; a first needle having a hollow shaft and a first length extending from the first end to provide an open distal end above the first end, the first needle having a second end vented through the sidewall; and a second needle having a hollow shaft and a second length extending from the first end generally parallel to the first needle to provide, when inverted, a distal end above the first end and below the distal end of the first needle, the second needle having a second end in fluid communication with the second end of the needle base. An associated method of use is also provided.

An operation tool for a fluid injector includes a selective movement mechanism which moves the fluid injector between a first protruding position and a second protruding position in a housing of an outer cylinder. When the fluid injector is at the first protruding position, microneedles of a multi-microneedle device are protruded out to a first distance from the first open end. When the fluid injector is at the second protruding position to discharge a fluid via the microneedles, the microneedles are protruded out to a second distance from the first open end, which is shorter than the first distance. The selective movement mechanism includes a rotational-linear movement conversion mechanism which moves the fluid injector between the first and second protruding positions along a longitudinal center line of the outer cylinder based on a direction and an amount of rotation of the outer cylinder relative to the fluid injector.

A multi-needle module suitable for skin procedure at slope is disclosed. The multi-needle module includes: a housing part; and a plurality of needles configured to be disposed in parallel in the housing part, wherein tips of the needles have an arrangement along a plane S1, and the plane S1 is a plane inclined by a predetermined angle with respect to a plane P2 perpendicular to the needles.

A gel composition which can be used suitably for a microneedle that can release insulin according to the glucose concentration in a self-regulated manner and a microneedle using the same. An insulin delivery microneedle comprises a base part fabricated with silk fibroin, at least one needle part integrally provided on the base part, and an insulin reservoir. At least a tip portion of the needle part comprises a composite gel composition comprising a copolymer comprising a phenylboronic acid-based monomer unit and silk fibroin.

The present disclosure relates to an insertion type drug injection device capable of being inserted into a body for injecting a drug into a skin, including: a main body having an open insert part and formed in a tubular shape having a hollow space therein, a needle assembly formed in the insert part, provided with a plurality of needles, and including a pneumatic port and a drug injection port, and a drug injection pipe inserted into the main body and connected to a drug injection port of the needle assembly, and an air flowing pipe connected to the pneumatic port.

An attachable needle assembly (102) for use on a medication delivery pen (104), the needle assembly (102) comprising a housing (110) enclosing a hub (106) having a communication needle (108) configured to engage the medication delivery pen (104) and pierce a reservoir septum of the medication delivery pen (104), a communication septum (172, 176) of the needle assembly (102) defining a septum chamber (180, 182) that is in fluid communication with the communication needle (108), a plurality of needles (118) disposed in the communication septum (172, 176), a follower ring (130) that determines which needle (124) of the plurality of needles (118) is to be selected, and a snap ring (136) that exposes the selected needle (124) and moves the selected needle (124) in fluid communication with the septum chamber (180, 182), wherein when the housing (110) is in a first position, the plurality of needles (118) is not exposed, and when the housing (110) is in a second position, the selected needle (124) is in fluid communication with the septum chamber (180, 182) and exposed for medicament delivery.

A magazine assembly (1) that stores a plurality of needles (56) configured to engage a medication pen (2) via an adapter (4) for medication delivery, the magazine assembly (1) comprising a magazine housing (20) enclosing a plurality of hub chambers (22) each enclosing one of a plurality of needle hubs (50), a connector (28) in each of the plurality of hub chambers (22), each connector (28) engages one of the plurality of needle hubs (50), and a plurality of enclosures (30) each sealing the plurality of hub chambers (22), wherein a selected enclosure of the plurality of enclosures (30) is removed to expose a selected needle hub (52) of the plurality of needle hubs (50), the adapter (4) attaches to the medication pen (2) to engage the selected needle hub (52) while disengaging the selected needle hub (52) from the hub chamber (22), and the selected needle hub (52) is removed from the magazine housing (20) to prepare the medication pen (2) for medication delivery.

A biosensor includes an optical circuit that obtains a plurality of photoplethysmography (PPG) signals from light at different wavelengths that is reflected from or transmitted through tissue of a user. A processing circuit determines a measurement value for a nitric oxide (NO) level in blood flow using first and second PPG signals and determines an insulin response from caloric intake using the measurement value for the NO level in blood flow. The first PPG signal is obtained from light at a wavelength having a high absorption coefficient for NO in blood flow and the second PPG signal is obtained from light at a second wavelength having a low absorption coefficient for NO in blood flow. The processing circuit also determines one or more phases of digestion using at least one or more of the plurality of PPG signals.

An automatic robotic apparatus for conducting a minimally invasive surgical procedure includes a robotic arm having a movable member made as the multilink active actuator. The end portion of the multilink active actuator is provided with the connector to which the hollow head for a needle biopsy is attached. The operation of the U-shaped head is under full control of the robotic apparatus computer system. Results of pre-procedure studies of a site of interest and the progression of the surgical procedure are displayed on a monitor of the computer system.

An optical circuit detects PPG signals reflected from skin tissue at one or more different wavelengths. A processing circuit integrated in the biosensor or in communication with the biosensor processes the PPG signals to obtain a period of vasodilation, a level of vasodilation and rate of change of the level of vasodilation. The processing circuit compares the level of vasodilation to a normal range and determines an arterial stiffness index using the comparison and the rate of change of the level of vasodilation.