A device for delivering a fluid into a biological tissue includes hollow microneedles (10) projecting from a surface (12) of a substrate (14), and a guide element (18) spaced from the substrate. The guide element provides a tissue-contact surface (20) that defines a tissue contact plane oblique to the surface (12) of the substrate (14).

A magazine assembly (1) that stores a plurality of needles (56) configured to engage a medication pen (2) via an adapter (4) for medication delivery, the magazine assembly (1) comprising a magazine housing (20) enclosing a plurality of hub chambers (22) each enclosing one of a plurality of needle hubs (50), a connector (28) in each of the plurality of hub chambers (22), each connector (28) engages one of the plurality of needle hubs (50), and a plurality of enclosures (30) each sealing the plurality of hub chambers (22), wherein a selected enclosure of the plurality of enclosures (30) is removed to expose a selected needle hub (52) of the plurality of needle hubs (50), the adapter (4) attaches to the medication pen (2) to engage the selected needle hub (52) while disengaging the selected needle hub (52) from the hub chamber (22), and the selected needle hub (52) is removed from the magazine housing (20) to prepare the medication pen (2) for medication delivery.

The invention relates to an injection device which includes a handle and a guard which together enclose a movable cartridge which can contain liquid material to be injected, and further enclose a movable injector that includes a needle, the needle being attached to a housing where the housing is attached to the cartridge, the device also including a delivery mechanism whereby the needle is moved from a retracted to an extended position, and independently the volume of the chamber may be adjusted to expel the contents thereof through the needle and into a subject in need thereof. The injection device may be communicatively connected to a control unit so as to provide a dermal injection system.

Systems, instruments, methods, and compositions are described involving removing a portion of the epidermis within a donor site on a subject, and harvesting dermal plugs within the donor site. An injectable filler is formed by mincing the dermal plugs. The injectable filler is configured for injecting into a recipient site on the subject.

A hollow needle device includes a main body having a first surface on which hollow acicular bodies are formed and a second surface opposite to the first surface, a main body supporting member having an opening that accommodates the main body and including a drop-out prevention mechanism for holding the main body that has the hollow acicular bodies being protruded from one end of the opening, an injector supporting member disposed detachably in the opening of the main body supporting member, and a liquid-tight structure that establishes liquid tightness between the injector supporting member and an inner surface that defines the opening in the main body supporting member. The injector supporting member has a connection hole to which a protrusion of an injector is detachably connected liquid tightly to guide an injection solution supplied from the injector into the opening via the protrusion of the injector.

A handheld vascular access device for gaining access to a patient's vessel includes a hub, a plurality of access needles and a manifold. The hub has an inner wall and side walls that define a plurality of ports. Each of the plurality of ports has a proximal port end and a distal port end. The proximal port ends define a proximal cross-sectional area and the distal port ends define a distal cross-sectional area. The proximal cross-sectional areas are greater than the distal cross-sectional areas. Each of the plurality of ports taper from the proximal port end to the distal port end. The plurality of hollow access needles is arranged along a plane and fixedly coupled to the distal end of the hub. Each of the plurality of needles has a tip. The manifold removably engages the hub at the proximal end of the hub.

A microneedle skin care device includes a housing having a predetermined space formed therein; a sound wave module disposed inside the housing to provide sound wave vibration; a microneedle assembly configured to receive vibration of the sound wave module and vibrate in front and rear directions, the microneedle assembly having microneedles disposed at a front end; and a needle tip coupled to the front end of the microneedle assembly and having through-holes through which the microneedles selectively pass through formed corresponding to the microneedles.

Apparatus and methods for medicament delivery. The apparatus may include, and the methods may involve, a delivery device for delivering a target amount of the medicament from a distal end of the device. The device may include a rod for moving a plunger that discharges the medicament from the distal end. The device may avoid or reduce deformation of the plunger during the discharge. The plunger motion may be stopped by detent that interacts with the rod. The apparatus and the methods may provide an operator indication of progress of stages of operation. The device may feature triggers corresponding to stages of medicament displacement from the device, such as pre-delivery stages, including priming.

An optical circuit detects PPG signals reflected from skin tissue at one or more different wavelengths. A processing circuit integrated in the biosensor or in communication with the biosensor processes the PPG signals to obtain a level of vasodilation or a period of vasodilation. The processing circuit may determine a circulation level using a phase offset between the PPG signals and/or a correlation value between the PPG signals.

A biosensor is implemented in an earpiece and includes an activity monitoring circuit that detects an activity level of a user and an optical circuit that detects a plurality of spectral responses at a plurality of wavelengths from light reflected from skin of the user. The biosensor determines a heart rate and an oxygen saturation level using the plurality of spectral responses and determines whether the heart rate or the oxygen saturation level reaches a predetermined threshold for the activity level of the user. The biosensor generates an alert and transmits the alert wirelessly to a remote device.