A sealant delivery apparatus for use in a lung access procedure to aid in preventing pneumothorax includes a sealant applicator device and an injection needle assembly. The injection needle assembly has a hub and an elongate hollow stylet. The hub is configured for removable connection to the sealant applicator device. The elongate hollow stylet is configured to facilitate fluid communication with at least one output port of the sealant applicator device to receive a multi-component sealant. The elongate hollow stylet has a proximal portion, a distal portion having a closed distal end, and a plurality of side ports proximal to the closed distal end. The plurality of side ports radially extend from a lumen and through a side wall of the elongate hollow stylet in the distal portion. The plurality of side ports are in fluid communication with the at least one output port of the sealant applicator device.

An injection delivery device involves a body, a medication-containing vial within at least a portion of the body, the medication-containing vial having an open end and a closed end opposite the open end. The open end of the vial includes a seal that prevents medication contained therein from exiting the vial until delivery of the medication to a target injection site is desired. The injection delivery device also includes a plunger positioned near the open end of the vial and a needle having a passage therethrough, wherein the needle, plunger and vial are positioned relative to each other such that, during delivery of an injection, a portion of the passage will be within the plunger, and the plunger and needle will remain stationary relative to each other while the vial moves relative the plunger in a direction towards the target injection site.

A device, a method, and a system for non-intrusive percutaneous delivery of analgesia into gingiva is disclosed. The disclosure includes a frame supporting a pressable reservoir filled with liquid anesthetic and has a plurality of hollow needles terminating at or adjacent a base portion. The method may have one or more two modes. This dual modality includes a first mode, wherein a topical anesthetic disposed along or adjacent the base portion may be applied to the gingiva. During a second mode, the pressable reservoir is manually compressed, whereby the needles are urged toward the patient, entering the gingiva and delivering the anesthetic. These two modes provide for an anesthetic process at the beginning of dental procedures in preparation for the final larger dose using a hypodermic needle.

A therapeutic hybrid microneedle patch mimics the inherent counter-regulatory effects of β-cells and α-cells for blood glucose management by dynamically releasing insulin or glucagon contained within the microneedles of the therapeutic hybrid microneedle patch. The two types of microneedles in the therapeutic hybrid microneedle patch share a co-polymerized matrix but comprise different ratios of the key monomers to be ‘dually-responsive’ to both hyper- and hypoglycemic glucose conditions. In a type 1 diabetic mouse model, the therapeutic hybrid microneedle patch effectively controls hyperglycemia while minimizing the occurrence of hypoglycemia in the setting of insulin therapy and simulated delayed meal or insulin overdose. In other embodiments, multiple patches are applied to achieve similar results.

Some embodiments are directed to a needle assembly including at least N injection needles where N is at least four and a multiple of two. The needle assembly also includes a first liquid port adapted to be connected to an injection device, and N second liquid ports connected to one of the N injection needles. N/2 main liquid pathways each have an entrance connected to the first liquid port and an exit, further including N/2 secondary liquid pathways that have two extremities each opening on one of the N second liquid ports, and a mid portion connected to the exit of one of the main liquid pathways. The main liquid pathways and the secondary liquid pathways define N liquid flow paths between the first liquid port and the N second liquid ports dimensioned so a pressure drop between them is similar.

Skin can be treated by piercing skin with a plurality of needles of an injection device and ejecting a dose of fluid therethrough. The device can include a housing, a plunger disposed in the housing, a cartridge disposed in the housing, and one or more dosing chambers. The plurality of needles can be coupled to the housing and be in fluid communication with the cartridge. Advancement of the plunger can cause a dose of fluid to be ejected from the plurality of needles.

A system comprising a handpiece and drive system configured to removably couple to a proximal end of a housing. A scalpet assembly is configured to removeably couple to the housing, and includes a scalpet array comprising at least one scalpet configured for rotation. The scalpet array is configured to harvest dermal plugs via fractional resection. A collection chamber is configured to collect the dermal plugs, and to house formation of an injectable filler by mincing the dermal plugs, and mixing the dermal plugs with a carrier. The injectable filler is configured for bulk fill. The collection chamber includes a loading port, and a cannular syringe is configured to mate with the loading port to receive the injectable filler, and to deliver the injectable filler for the bulk fill.

A fluid delivery device for administering a first medicament and a second medicament includes a first fluid reservoir configured to contain the first medicament and a second fluid reservoir configured to contain the second medicament. The fluid delivery device may include one or more basal drive mechanisms to provide a basal delivery of one or more of the first and second medicaments. The fluid delivery device may further include one or more bolus drive mechanisms to provide a bolus delivery of one or more of the first and second medicaments.

A hypodermic device is disclosed comprising a chamber, an array of hypodermic needles and a threaded Luer lock connector. The chamber comprises a distal outer surface and a proximal outer surface. The array of hypodermic needles projects outward from the distal outer surface of the chamber. Each hypodermic needle comprises a bore extending from a receiving end of the hypodermic needle to a delivery end of the hypodermic needle along a longitudinal axis. The bore in each of the hypodermic needles is in fluid communication with a hollow space in the chamber. The threaded Luer lock connector is in fluid communication with an opening at the proximal outer surface of the chamber. A first end of the threaded Luer lock connector is connected to the proximal outer surface of the chamber.

The invention relates to an injection device which includes a handle and a guard which together enclose a movable cartridge which can contain liquid material to be injected, and further enclose a movable injector that includes a needle, the needle being attached to a housing where the housing is attached to the cartridge, the device also including a delivery mechanism whereby the needle is moved from a retracted to an extended position, and independently the volume of the chamber may be adjusted to expel the contents thereof through the needle and into a subject in need thereof. The injection device may be communicatively connected to a control unit so as to provide a dermal injection system.