Self-puncturing liquid drug cartridges and an associated inhaler are used to deliver one or more separate doses of an aerosolized liquid drug. A cartridge includes a needle assembly coupled to a drug container. The needle assembly includes a hollow needle and is reconfigurable from a first configuration to a second configuration upon insertion of the cartridge into the inhaler. In the first configuration, the hollow needle does not extend into the container. In the second configuration, the hollow needle extends into the container. The inhaler includes an aerosol generator that includes a vibratable membrane that aerosolizes liquid drug ejected from the cartridge for inhalation by a patient.

Methods and devices for handling a fluid and delivering the fluid to the eye. The device has a vibrating element with a plurality of openings through which a fluid is ejected when the vibrated. An enclosure defines a chamber which holds a single application of the fluid. The enclosure may be biased against the vibrating element with a spring load developed in whole or part by the resilient structure of the enclosure. The chamber may be substantially empty after the single application.

An inhaler article includes a tubular housing defining a holder body extending along a longitudinal axis from a mouthpiece end to a consumable receiving end. The holder body includes an inner tube extending along the longitudinal axis and within the tubular housing from a tube intake end to a tube exhaust end. The tube intake end is proximate the consumable receiving end. The inner tube defines an air flow lumen with two or more air flow apertures extending through a wall of the inner tube. An air blocking feature is positioned in the air flow lumen and between two of the air flow apertures. A vibration inducing element disposed on the inner tube proximate to the tube exhaust end or the tube intake end, the vibration inducing element comprises an aperture through the wall of the inner tube and having a tapered or angled downstream aperture edge.

A nicotine powder consumable article includes an elongated consumable body extending between a proximal end and a distal end. A capsule is fixed within the elongated consumable body. The elongated consumable body contacts the capsule. The capsule contains particles comprising nicotine or a pharmaceutically acceptable salt thereof. A first plug of material is disposed within the elongated consumable body and between the capsule and the proximal end. A second plug of air porous material is disposed within the elongated consumable body and between the capsule and the distal end. The second plug of air porous material is not in air-flow communication with the first plug of material.

The present invention provides methods and a BFS/FFS system for delivering either one or more substances within at least one body cavity, characterized by a vial comprising V.sub.sub [ml] of said substances; said vail selected from a pierceable container, a blow-fill-seal and a form-fill-seal, having fluid inlet and a fluid discharging outlet of diameter D [mm], configured for placement in proximity to said body cavity; said fluid inlet configured by means of size and shape to interface in a sealable manner a puncturing member, configured to, upon coupling to said fluid inlet, piercing the same, thereby providing said substances in a fluid communication, via a valve, with a chamber configured to accept pressurized fluid at volume V.sub.PF [ml] and pressure P.sub.PF [barg]; said valve is commutable from an CLOSE to an OPEN CONFIGURATION within a short period of time, <500 milliseconds (dT); at said OPEN CONFIGURATION, said pressurized fluid flows from said chamber, via said fluid inlet, entrains said substances by one of the followings: (i) one portion m.sup.V.sub.PF/n, n=portion (%, v/v), m=1, (ii) a plurality of portions, m.sup.V.sub.PF/n, m2, or (iii) the whole V.sub.PF, n,m=1 erupts via said fluid discharging outlet to within said body cavity.

The present invention relates to an inhalation device (1), to the use thereof, and to a kit comprising the inhalation device. The inhalation device (1) has an air inlet (14), an air outlet (15) designed as a mouthpiece or nosepiece, and a recess (17) which is designed to receive a container (2) with an inhalable substance. An air duct (L) extends from the air inlet (14) through the recess (17) to the air outlet (15). Moreover, the inhalation device (1) has at least one hollow mandrel (16, 16) which protrudes into the recess (17) and from which at least one air delivery line (14, 14) extends to the air inlet (14) or at least one air outlet line (15) extends to the air outlet (15). The inhalation device (1) is characterized in that the inhalation device (1) has two limbs (11, 12), each with a work end (11, 12) and with an actuation end (11, 12), wherein the limbs (11, 12) are connected by means of a joint (13) which lies between the work ends (11, 12) and the actuation ends (11, 12). Furthermore, the recess (17) is defined between the mutually facing sides of both limbs (11, 12) at the work ends (11, 12), wherein the at least one hollow mandrel (16, 16) is arranged inside the recess (17) on one of the mutually facing sides of both limbs (11, 12). The air inlet (14) and the air outlet (15) are arranged at the work end (11, 12) on a side, directed away from the recess (17), of at least one of the limbs (11, 12).

The multi-chambered well dosage form and device disclosed herein can be single or multi dose capable for administration of pharmaceuticals of a range of particle sizes. The present dosage devices and systems provide for improved efficiency and patient ease of use owing to its compact size and simple design, low cost, and consistent, contamination free dosing of dry powder medicaments or other agents. The present disclosure provides a multi-chambered dosage form containing dry powder medical composition containing chamber well with an internal piercing device and one or more adjacent gas-filled chamber wells to aid the dispense of the powder contents to the user and in certain embodiments, without the requirement of an external energy sources common with active devices known in the art. Said methods, systems and devices provide increased ejection fraction and hence greater efficiency of drug delivery above that as provided by current devices.

A fluid dispenser device with a main body (10); a reservoir (21) containing a dose of powder; a reservoir opening mechanism (80); a dispenser orifice (5); a movable support mechanism (50) to displace a reservoir (21) against the opening mechanism on actuation and displaceable between a non-dispensing position and a dispensing position, urged towards the dispensing position, and held in the non-dispensing position by a blocking mechanism (100). An inhalation trigger system (60) is provided that has a deformable air chamber (61) and a trigger element (600) that co-operates firstly with the air chamber (61) and secondly with the blocking mechanism. The fluid dispenser device further includes an electronic dose counter or indicator device (300) including a sensor (306) to detect displacement or deformation of a portion of the fluid dispenser device, generated while the user is inhaling or after the user has inhaled.

An aerosol-generating system may include a liquid storage portion, a vaporizer, and a pump. The liquid storage portion may be configured to store a liquid aerosol-forming substrate. The vaporizer may be configured to volatilize the liquid aerosol-forming substrate. The pump may be configured to pump air into the liquid storage portion so as to push out a volume of the liquid aerosol-forming substrate from the liquid storage portion and to supply the volume of the liquid aerosol-forming substrate to the vaporizer. A method for generating an aerosol may be performed with the system.

Cartridges for vaporizer devices are provided. In one exemplary embodiment, the cartridge can include a reservoir housing having a first housing end and a second housing end opposite the first housing end, an airflow tube that extends through the reservoir housing, and first and second seals that are each substantially impermeable to fluid, in which the first seal is substantially secured to the first housing end and the second seal is substantially secured to the second housing end. The reservoir housing is configured to hold vaporizable material and the first and second seals are configured to be selectively compromised to allow access to the vaporizable material within the reservoir housing for vaporization into vaporized material. Vaporizer devices are also provided.