Various exemplary drug syringes with a mechanical stop for a second dose, drug products utilizing the same, and methods of using drug syringes with a mechanical stop for a second dose are provided. In general, a nasal drug delivery device is configured to dispense therefrom first and second doses of a drug therefrom into a nose. The drug delivery device includes a mechanical stop configured to provide a pause between the delivery of the first and second doses. During the pause, a user of the drug delivery device can move the drug delivery device from one nostril, into which the first dose was sprayed, to another nostril, into which the second dose can be sprayed. The mechanical stop is configured to hold the drug delivery device in a static delivery state.

Various exemplary drug holders (102, 200) for drug delivery devices (100), drug products utilizing the same, and methods of using drug holders for drug delivery devices are provided. In general, a nasal drug delivery device is configured to dispense therefrom at least one dose of a drug therefrom into a nose. The drug delivery device includes a drug holder that contains the drug therein that is delivered out of the drug delivery device. The drug holder can include two cavities (208, 210) therein that are fluidically sealed from one another prior to use of the drug delivery device to cause drug delivery. A first one of the cavities includes the drug therein, and a second one of the cavities includes a drug or air therein.

A reservoir for a nebulizer includes: a tank or bag containing multiple doses of a fluid to be nebulized, and an indicator device for counting or indicating a number of uses performed or still possible with the reservoir, where at least one of: the reservoir includes a connector for fluidically connecting the tank or bag with the nebulizer, the indicator device is actuated by moving the connector relative to the tank or bag, and the reservoir includes or forms an eccentrical linear guidance for a driving part for driving the indicator device.

A nebulizer for nebulizing a fluid is proposed. The nebulizer includes an indicator device with a rotatable indicator element for counting or indicating a number of actuations performed or still possible with the nebulizer and a rotatable shaft which rotatably drives the indicator element. The indicator device is non-detachably attached to the shaft and/or to an inner part of the nebulizer. The nebulizer may further include a positioning device that keeps the shaft in a defined rotational position and/or blocks the shaft from rotating backwards.

Device having a reservoir, a head provided with a dispensing hole, a stopper displaceable in the reservoir between a rest position and an actuation end position to dispense fluid product through the dispensing hole. The reservoir formed by a hollow, blind body having a base and a single opening which, in the rest position, is closed in a fluid-tight manner by the stopper, the device having an insert fixed in the head, the insert supporting a cannula for piercing the stopper and connecting the reservoir to the dispensing hole. The insert has at least one projection provided with a lower surface, the lower surface cooperating at the end of actuation with the reservoir in order to define the actuation end position of the stopper.

Methods are provided for acute treatment of agitation, including agitation in patients with schizophrenia or bipolar disorder, comprising administering to a subject with agitation an effective dose of a dry pharmaceutical composition comprising olanzapine, wherein the dose is administered by an intranasal delivery device that provides, following intranasal administration, (a) a mean peak plasma olanzapine concentration (C.sub.max) of at least 30 ng/mL, with (b) a mean time to C.sub.max (T.sub.max) of olanzapine of less than 0.5 hours. Dry pharmaceutical compositions and devices suitable for intranasal delivery of olanzapine are provided.

A nebulizer for a fluid, includes a container containing the fluid; a housing part which can be detached from the nebulizer for replacing the container; an inner part; a retaining element connected with and not detachable from the inner part, where the housing part is releasable fixed to the inner part by the retaining element; a delivery mechanism for dispensing the fluid; a manually depressible actuator member, which is a separate part from the retaining element and acts on the retaining element, and wherein the actuator member is depressed to elastically deform or flex the retaining element to allow detachment of the housing part.

A vapor-generating system includes a cartridge, a vapor-generating device and a piercing element. The cartridge includes a cartridge housing configured to hold a solid vapor-forming substrate within the cartridge housing interior, a liquid storage housing configured to hold a liquid vapor-forming substrate within the liquid storage housing interior, and a frangible seal on the liquid storage housing. The vapor-generating device includes a device housing at least partially defining a cavity, an electric heater, and a power supply. The piercing element is configured to pierce the frangible seal of the cartridge to expose the liquid storage housing interior to be in fluid communication with the electric heater based on the vapor-generating device coupling with the cartridge such that the device housing at least partially receives the cartridge into the cavity. The electric heater is located externally from the piercing element.

Methods are provided for acute treatment of agitation, including agitation in patients with schizophrenia or bipolar disorder, comprising administering to a subject with agitation an effective dose of a dry pharmaceutical composition comprising olanzapine, wherein the dose is administered by an intranasal delivery device that provides, following intranasal administration, (a) a mean peak plasma olanzapine concentration (C.sub.max) of at least 30 ng/mL, with (b) a mean time to C.sub.max (T.sub.max) of olanzapine of less than 0.5 hours. Dry pharmaceutical compositions and devices suitable for intranasal delivery of olanzapine are provided.

Device for dispensing a fluid product having a body (1) and dispensing head (2) provided with a dispensing opening (3) and axially movable with respect to the body (1) during actuation. The body (1) accommodates a reservoir (10) containing one or two doses of fluid product. The device has an electronic module (100) with a wireless communication module (101), a geographical location module (102), and a power source (103). The device has a system of sensors (200, 201, 202) for detecting and signaling, automatically, an attempt to actuate the device, when a first sensor (200) is activated. The wireless communication module (101) is adapted to make an automatic emergency call to an emergency number when the sensor system detects an attempt to actuate the. The first sensor is activated when it detects an actuation force greater than 5N or 10N.