A humidification system has a humidification source and a main gases flow path. The main gases flow path has a low pressure region and a high pressure region. In some embodiments, each of the low pressure region and the high pressure region has an aperture. The pressure difference between the apertures promotes a gases flow between the main gases flow path and the humidification source, and results in humidifying the gases in the main gases flow path.

In general terms the present invention proposes a manifold 100 for delivery of medicament powder from a dispenser device. The manifold 100 comprises a first chamber 102 comprising a first chamber inlet 102A and a first chamber outlet 102B. The first chamber 102 is arranged to direct a first flow of air 110 from the first chamber inlet 102A to the first chamber outlet 102B. The manifold 100 also comprises a conduit 104 having a conduit inlet 104A and a conduit outlet 104B. The first chamber outlet 102B and conduit inlet 104A are arranged such that when a supply of medicament powder is positioned proximal thereto the first flow of air 110 is directed from the first chamber outlet 102B to the conduit inlet 104A via the supply of medicament powder to entrain the medicament powder and provide a flow of air entrained with medicament powder through the conduit 104. The manifold 100 has a bleed inlet 106 in a wall of the conduit 104 outside of the first chamber 102 arranged to direct a second flow of air 112 into the conduit 104 to disruptively impact the flow of air entrained with medicament powder through the conduit 104.

[FIG. 1C]

In one aspect of the present disclosure, an apparatus for delivering a powdered agent into a subject's body may include a powder chamber housing the powdered agent. The apparatus also may include a chassis in fluid connection with the powder chamber. The chassis may include a first passage for receiving a pressurized gas, a second passage for receiving the powdered agent from the powder chamber, and a junction in fluid communication with the first passage and the second passage. At least a first portion of the pressurized gas is introduced into the powdered agent at the junction to fluidize the powdered agent.

Systems and methods for generating nitric oxide are disclosed. A nitric oxide (NO) generation system includes at least one pair of electrodes configured to generate a product gas containing NO from a flow of a reactant gas; and a controller configured to regulate the amount of nitric oxide in the product gas produced by the at least one pair of electrodes by utilizing duty cycle values of plasma pulses selected from a plurality of discrete duty cycles to produce a target rate of NO production based on an average of discrete production rates associated with each of the plurality of discrete duty cycles.

A breathing assistance device with improved pressure characteristics provides a high level of CPAP per unit of supplementary respirable gas consumed while maintaining low CPAP fluctuations throughout the breath cycle utilizing a frustrum-shaped air channel to accelerate air flow. In some embodiments, a manometer is provided for monitoring pressure and/or a pressure relief valve is provided as a safety measure against overpressure delivered to a patient. In some embodiments, the device is disposable for one-time or single patient use.

A breathing assistance device with improved pressure characteristics is capable of providing a high level of CPAP per unit of supplementary respirable gas consumed while maintaining low CPAP fluctuations throughout the breath cycle. The invention also includes a manometer for monitoring pressure and a safety pressure relief valve as additional safety measures against overpressure delivered to a patient. In some embodiments, the device is disposable for one-time or single patient use.

An ambulatory assist ventilation (AA V) apparatus and system are disclosed for the delivery of a respiratory gas to assist the spontaneous breathing effort of a patient with a breathing disorder. The AA V system includes a compressed respiratory gas source, a respiratory assist device for controlling respiratory gas flow to the patient, a patient circuit tubing and a low profile nasal interface device, which does not have a dead space or hollow area where CO2 can collect, for delivering the respiratory gas to the patient, wherein the nasal interface device is fluidly connected to the respiratory assist device via tubing for receiving the respiratory gas therefrom.

In one aspect of the present disclosure, an apparatus for delivering a powdered agent into a subject's body may include a powder chamber housing the powdered agent. The apparatus also may include a chassis in fluid connection with the powder chamber. The chassis may include a first passage for receiving a pressurized gas, a second passage for receiving the powdered agent from the powder chamber, and a junction in fluid communication with the first passage and the second passage. At least a first portion of the pressurized gas is introduced into the powdered agent at the junction to fluidize the powdered agent.

A valve assembly attached to a capacitor such that pressurizing the capacitor to a first positive pressure threshold induces the valve assembly to open, the pressurized air is released to the patient, and then as the pressure in the capacitor drops to a second pressure threshold the valve closes and the capacitor begins to build pressure until the first positive pressure threshold is achieved and the process repeats. Relative to the valve assembly and integrated therein, is an incrementally adjustable index knob to vary the rate of a biasing force performing work against the actionable valve face of the diaphragm functional surface to set the performance of the valve assembly, thereby increasing the potential for correct operation across a range of oscillating rates supporting a broad spectrum of patient therapies and types.

A transportable lung ventilator allowing for automatic selection between oxygen and air for feeding a venturi type ventilation system comprising a monobloc body with at least one medical oxygen inlet; at least one compressed air inlet; and at least one ambient air inlet; at least a selector valve integrated with the monobloc body and adapted to allow, selectively, the passage of medical oxygen or compressed air; a venturi system, internal to the monobloc body, comprising an injector nozzle and a venturi tube, the injector nozzle receiving the medical oxygen or the compressed air passing through the selector valve and generating a jet towards the venturi tube, the jet dragging ambient air through the ambient air inlet to generate a mixture of gases to be ventilated to a patient; a fraction of inspired oxygen sensor that measures the concentration of oxygen in the gas mixture; and an electronic control system that controls the selector valve to allow the passage of medical oxygen or compressed air based on the oxygen concentration measured by the fraction of inspired oxygen sensor.