Devices, systems, and methods for removing targeted lesions from vessels. In at least one embodiment of a device for removing a stenotic lesion from a vessel, the device comprises a sizing portion capable of measuring a luminal size parameter when at least part of the device is positioned within a lumen of a luminal organ, a typing portion, wherein at least part of the at least one typing portion is capable of physically touching a portion of the luminal organ or a structure therein, and a treatment portion capable of removing at least part of a stenotic lesion from the luminal organ.

A syringe assembly or inflation device that includes a detachable housing. A pressure-sensing syringe assembly or inflation device can include both a syringe barrel and a housing that is coupled to the syringe barrel in a locked configuration. The inflation device can transition from the locked configuration to the unlocked configuration in which the housing is separable from the syringe barrel. Related methods are also disclosed.

Systems and methods and devices are provided for arresting or reversing the effects of myocardial remodeling and degeneration after cardiac injury, without the potential drawbacks associated with previously existing systems and methods, by at least partially occluding flow through the superior vena cava over multiple cardiac cycles, and more preferably, by adjusting the interval or degree of occlusion responsive to a sensed level of patient activity. In some embodiments, a controller is provided that actuates a drive mechanism responsive to a sensed level of patient activity to provide at least partial occlusion of the patient's superior vena cava, while a data transfer circuit of the controller provides bi-directional transfer of physiologic data to the patient's smartphone or tablet to permit display and review of such data.

The disclosure relates to devices and methods for the treatment of edema, which devices use a restrictor for flow compensation. Devices and methods of the invention further use a flow-restrictor in the circulatory system, upstream of an intravascular pump, to balance pressure changes induced by the pump and to compensate for downstream flow. The device may be provided as an indwelling, intravascular catheter with a mechanical pump such as an impeller and a selectively deployable restrictor such as an inflatable balloon. Congestive heart failure or edema is treated by operating the pump in an innominate vein and using the restrictor for flow compensation, to restrict the upstream flow and thus amplify or maintain pressure reduction at the lymphatic outlet.

Some embodiments of a balloon catheter device for introduction into a body vessel, in particular the coronary sinus, can include a catheter shaft which carries an inflatable balloon on its distal portion and in which a plurality of different lumens are formed. In particular embodiments, a system for treating heart tissue can include a coronary sinus occlusion catheter configured for improved deliverability to the coronary sinus and for thereafter performing intermittent occlusion of the coronary sinus.

Some systems and methods for operating a vessel occlusion catheter may include a control and inflation device to control the filling of the balloon in such a manner that the vessel wall will not be overstressed while the safe occlusion of the blood vessel is achieved.

Devices used to pressurize, depressurize, or otherwise displace fluid are disclosed. The devices may be configured to displace fluid in order to inflate or deflate a medical device, such as a balloon. The devices further include a crank member for providing a mechanical advantage when pressurizing or otherwise displacing fluid. The devices further include adding reinforcement fibers and slip agents to polymeric materials.

A dilation catheter system is provided to dilate the ostium of a paranasal sinus or some other anatomical passageway (e.g., within the ear, nose, or throat, etc.). The system may include a dilation catheter, a dilator, a guide catheter, and an inflator. The dilation catheter may be positioned between the dilator and the inflator. The guide catheter is configured to guide the dilator into the affected passageway. The inflator may then be actuated to transfer fluid from the inflator, through the dilation catheter, and into the dilator. The transfer of fluid may inflate the dilator to an expanded state to open or dilate the affected passageway. The inflator may include a body, a plunger assembly, and locking features that selectively secure the position of the plunger assembly relative to the body by moving along a path that is transverse to a longitudinal axis defined by the plunger assembly.

Systems and methods are provided for treating conditions such as heart failure and/or pulmonary hypertension by at least partially occluding flow through the superior vena cava for an interval spanning multiple cardiac cycles. A catheter with an occlusion device is provided along with a controller that actuates a drive mechanism to provide at least partial occlusion of the patient's superior vena cava, which reduces cardiac filling pressures, and induces a favorable shift in the patient's Frank-Starling curve towards healthy heart functionality and improved cardiac performance. The system may include sensors to determine the degree of occlusion of the superior vena cava. The occlusion system may be used to reduce volume in a heart and facilitate a cardiac procedure. The occlusion system may be used to relieve an overloaded chamber during and/or after deploying a VAD.

A medical system for assisting in the planning and/or performance of the reconstruction of normally symmetrical body parts of a patient comprises a measuring unit for measuring a first surface and a second surface for determining a topography of the first and second surfaces, a storage unit for storing the determined topographies of the first and second surfaces, an evaluation unit for establishing a mirror image of the stored topography of the first surface and for calculating deviations of the stored topography of the second surface from the first surface mirror image, and a control unit for outputting guidance information for at least one medical instrument on the basis of the calculated deviations of the topography of the second surface, in order to reconstruct the topography of the second surface according to the mirror image of the topography of the first surface.