An apparatus and process for extracorporeal treatment of blood comprising a treatment unit, a blood withdrawal line, a blood return line, a preparation line and a spent dialysate line. A control unit is configured to calculate values of a parameter relating to treatment effectiveness based on measures of lactate or citrate or acetate concentration in the spent dialysate line.

An apparatus and process for extracorporeal treatment of blood comprising a treatment unit, a blood withdrawal line, a blood return line, a preparation line and a spent dialysate line. A control unit is configured to calculate values of a parameter relating to treatment effectiveness based on measures of lactate or citrate or acetate concentration in the spent dialysate line.

A dialysis machine (e.g., a peritoneal dialysis (PD) machine) can include a control unit configured to operate in a hybrid automated mode during a PD treatment. A processor in the control unit is configured to engage a pump during a fill phase of the PD cycle. The volume of fluid (e.g., dialysate) transferred to a patient line during the fill phase is monitored. After a dwell period, the pump is disengaged at the start of a drain phase of the PD cycle. Disengaging the pump can include: configuring valves of a disposable cassette to bypass the pump chambers of a disposable cassette; activating a bypass valve to shunt the patient line to a drain line; or moving a roller assembly of a peristaltic pump. The fluid transferred from the patient line to the drain line is monitored during the drain phase of the PD cycle.

A dialysis machine (e.g., a peritoneal dialysis (PD) machine) can include a control unit configured to operate in a hybrid automated mode during a PD treatment. A processor in the control unit is configured to engage a pump during a fill phase of the PD cycle. The volume of fluid (e.g., dialysate) transferred to a patient line during the fill phase is monitored. After a dwell period, the pump is disengaged at the start of a drain phase of the PD cycle. Disengaging the pump can include: configuring valves of a disposable cassette to bypass the pump chambers of a disposable cassette; activating a bypass valve to shunt the patient line to a drain line; or moving a roller assembly of a peristaltic pump. The fluid transferred from the patient line to the drain line is monitored during the drain phase of the PD cycle.

An assembly with a blood pump and a control unit to control the flow rate at the blood pump includes a device that is designed to deliver a parameter of the breathing cycle or a parameter associated with the breathing cycle. In this way, it is also made possible for a parameter that correlates to the breathing cycle to be used to control the blood pump, in order to proactively prevent problems associated with the drainage.

A peristaltic pump includes a motor, a rotor coupled to the motor, a housing in which the rotor is arranged, and an opening and closing mechanism. The mechanism includes a tube pressuring portion, a slider, and a pivotable cover coupled to the housing and the slider and the mechanism is connected to the slider and the tube pressuring portion such that a tube engaging surface of the tube pressuring portion slides towards and away from the rotor upon closing and opening of the pivotable cover. The opening and closing mechanism further includes a slider moving element attached to the slider, the pivotable cover including a rotating shaft having an extension configured to engage the slider moving element for moving the slider and also the tube pressuring portion away and towards a top of the housing in response to a respective opening and closing of the pivotable cover.

A peristaltic pump includes a motor, a rotor coupled to the motor, a housing in which the rotor is arranged, and an opening and closing mechanism. The mechanism includes a tube pressuring portion, a slider, and a pivotable cover coupled to the housing and the slider and the mechanism is connected to the slider and the tube pressuring portion such that a tube engaging surface of the tube pressuring portion slides towards and away from the rotor upon closing and opening of the pivotable cover. The opening and closing mechanism further includes a slider moving element attached to the slider, the pivotable cover including a rotating shaft having an extension configured to engage the slider moving element for moving the slider and also the tube pressuring portion away and towards a top of the housing in response to a respective opening and closing of the pivotable cover.

The present disclosure provides systems and methods for controlling gas-enrichment, e.g., oxygen-enrichment, therapy. One or more sensors and/or one or more imaging systems may be used to measure or determine one or more physiological parameters of the patient. Feedback regarding one or more physiological parameters or microvascular resistance may be provided for titrating or controlling the gas-enrichment therapy.

The present disclosure provides systems and methods for controlling gas-enrichment, e.g., oxygen-enrichment, therapy. One or more sensors and/or one or more imaging systems may be used to measure or determine one or more physiological parameters of the patient. Feedback regarding one or more physiological parameters or microvascular resistance may be provided for titrating or controlling the gas-enrichment therapy.

A cardiac pump is arranged to mimic triphasic operation. The pump uses a fluid line formed from flexible tubing, along with a reciprocating actuator arranged to move between a free orientation and an occluding orientation. This allows a portion of the fluid line to be selectively occluded during movement of the actuator, enabling blood or other fluids to be peristaltically forced fluid towards a fluid outlet. The direction of operation of the actuator, and the selection of appropriate occluding or free orientations, allows the pump to be operated in a triphasic manner.