The invention relates generally to systems and devices for material delivery, energy delivery, and/or monitoring electrophysiological activity, and method of use thereof. In particular, the present invention provides devices and systems, and methods of use thereof, configured to deliver therapeutic compositions, to provide electroporation and/or sonoporation to increase therapeutic efficiency, and to monitor electrophysiological activity, for example, before and after treatment.

This document describes methods and materials for improving treatment of hypertension. For example, this document describes methods and devices for electroporation of nerves in the renal area to treat hypertension.

The disclosure is directed to a device for electroporating and delivering one or more antigens and a method of electroporating and delivering one or more antigens to cells of epidermal tissues using the device. The device comprises a housing, a plurality of electrode arrays projecting from the housing, each electrode array including at least one electrode, a pulse generator electrically coupled to the electrodes, a programmable microcontroller electrically coupled to the pulse generator, and an electrical power source coupled to the pulse generator and the microcontroller. The electrode arrays define spatially separate sites.

A device for delivery of electrical pulses to a desired tissue of a mammal. The device comprises a pulse generating device and an electrode device connected to the pulse generating device. The pulse generating device is configured to determine conductance and phase angle values between one electrode and a reference electrode of the electrode device when the electrode device is inserted into the desired tissue and when pulses based on alternating currents having different frequencies are generated between the electrode and the reference electrode. Based on the determined conductance and phase angle values, the pulse generating device is configured to determine the type of tissue the electrode device penetrates, to determine one or more parameters of electrical pulses to be delivered to the desired tissue and to generate the electrical pulses having the determined one or more parameters.

A method and apparatus are provided for delivering an agent into a cell through the application of nanosecond pulse electric fields (nsPEF's). The method includes circuitry for delivery of an agent into a cell via known methods followed by the application of nanosecond pulse electric fields to said cell in order to facilitate entry of the agent into the nucleus of the cell. In a preferred embodiment, the present invention is directed to a method of enhancing gene expression in a cell comprising the application of nanosecond pulse electric fields to said cell. An apparatus for generating long and short pulses according to the present invention is also provided. The apparatus includes a pulse generator capable of producing a first pulse having a long duration and low voltage amplitude and a second pulse having a short duration and high voltage amplitude.

Techniques for High-Frequency Irreversible Electroporation (HFIRE) using a single-pole tine-style internal device communicating with an external surface electrode are described. In an embodiment, a system for ablating tissue cells in a treatment region of a patient's body by irreversible electroporation without thermally damaging the tissue cells is described. The system includes at least one single-pole electrode probe for insertion into the treatment region, the single-pole electrode probe including one or more tines. The system further includes at least one external surface electrode for placement outside the patient's body and configured to complete a circuit with the single-pole electrode probe. The system also includes a control device for controlling HFIRE pulses to the single-pole tine-style electrode and the skin-surface electrode for the delivery of electric energy to the treatment region. Other embodiments are described and claimed.

Devices and methods can be used to treat dermatologic disorders using low dose DC electroporation. Such electroporation is essentially non-thermal modulation. In some implementations, the devices and methods described herein can be used for anti-aging treatments. In some implementations, the devices and methods described herein can be used for detecting/screening of various types of skin cancers. In some implementations, the devices and methods described herein can be used for therapy delivery for the treatment of early or pre-malignant skin cancers.

Methods and apparatuses (systems, devices, etc.) for treating biological tissue to evoke one or more desirable biological and/or physiological effects using pulsed electric fields in the sub-microsecond range at very low electric field strength (e.g., less than 1 kV/cm) but at high (e.g., megahertz) frequencies.

Provided is a facial massage device including: a massage head (1) that includes: a bearing element (20) that is intended to be placed against the face and that defines a bearing surface (S), at least one massage finger (21), each including a working head (22) intended to come into contact with the face and each being mobile between: a retracted position (R) in which the working head (22) is located short of the bearing surface (S) towards the inside of the massage head (1), an extended position (E) in which the working head (22) is located beyond the bearing surface (S) towards the outside of the massage head (1), means (25) for manoeuvring each massage finger (21) designed to move each of the massage fingers (21) alternately between the extended position (E) and the retracted position (R) thereof, and a drive housing (2) that carries the massage head (1) and that includes an electric motor (6) that actuates drive means (7) designed to transmit the drive from the electric motor (6) to the manoeuvring means (25), wherein the drive housing (2) is located opposite the working heads, relative to the bearing element (20).

A pharmaceutical device for electric-field assisted administration of Tapentadol and/or of a physiologically acceptable salt thereof, the device comprising at least one pair of electrodes consisting of an active electrode and a counter electrode (1a and 2a and/or 1b and 2b), optionally at least one additional electrode as an auxiliary electrode, at least one drug reservoir (3) containing at least a portion of the Tapentadol and/or a physiologically acceptable salt thereof, and means (4) for applying the device to skin (5).