A method and system for monitoring an electrotherapy treatment applied to a subject in need of such therapy. An ultrasound transducer array is positioned adjacent a tissue of the subject to which the electrotherapy treatment is to be applied. The electrotherapy treatment is administered to the tissue as a plurality of ultra-short electric pulses which generate an electric field in the vicinity of the tissue. The ultrasound transducer array detects acoustic signals which are induced by the electric field. The detected acoustic signals are then used to construct tomographic images which represent the electric field generated by the electrotherapy treatment during real-time.

The invention relates generally to systems and devices for material delivery, energy delivery, and/or monitoring electrophysiological activity, and method of use thereof. In particular, the present invention provides devices and systems, and methods of use thereof, configured to deliver therapeutic compositions, to provide electroporation and/or sonoporation to increase therapeutic efficiency, and to monitor electrophysiological activity, for example, before and after treatment.

A flexible electrode (1) for applying an electric field to the human body, comprising: a gripping portion (3); a deformable structure (5) having a first face (5a) fixed to the gripping portion (3); a flexible polymeric film (7) arranged on a flat second face (5b) of the deformable structure (5) and provided, on a flat face (7a) thereof facing outwards the electrode (1), with flat metal structures (10,11) defining at least one first electrode and one second electrode (A,B), surfaces (10a,11a) of the flat metal structures (10,11) facing outwards the polymeric film (7) being coplanar with the flat face (7a) of the polymeric film (7).

The present disclosure relates generally to electroporation systems and utilizing algorithms for electroporation pulse delivery including a patient's EKG/EGM monitoring. In some embodiments, an electroporation delivery system may include an electrocardiogram operatively connected to a processing device and a memory. One or more sensors may be operatively connected to the electrocardiogram for measuring electrical activity QRS complex of a patient's heart. One or more electrodes for treatment may be disposed in, at, or near the patient's heart, the one or more electrodes operatively connected to a pulse delivery mechanism. The electroporation delivery system may be configured to determine whether an electroporation pulse is deliverable to a patient based on the electrocardiogram.

Provided herein are methods of generating a biologically effective unipolar nanosecond electric pulse by superposing two biologically ineffective bipolar nanosecond electric pulses and related aspects, such as electroporation and/or therapeutic applications of these methods to non-invasively target electrostimulation (ES) selectively to deep tissues and organs.

A new method for the ablation of undesirable tissue such as cells of a cancerous or non-cancerous tumor is disclosed. It involves the placement of electrodes into or near the vicinity of the undesirable tissue through the application of electrical pulses causing irreversible electroporation of the cells throughout the entire area of the undesirable tissue. The electric pulses irreversibly permeate the cell membranes, thereby invoking cell death. The irreversibly permeabilized cells are left in situ and are removed by the body immune system. The amount of tissue ablation achievable through the use of irreversible electroporation without inducing thermal damage is considerable.

The present application relates to a flexible cosmetic article comprising at least one substrate (50) on which at least a first pair of electrodes (2,3) and a one-piece unit (12) are placed, the one-piece unit (12) comprising at least one electric power source (1,11) as well as a repositionable adhesive material (5) on at least one portion of its outer surface (33) facing the first pair of electrodes (2,3).

Methods and related systems for modulating neural activity by modulating neural activity in a nerve plexus of a subject are disclosed. Neural activity may be modulated by stimuli delivered via various types of stimulus sources. Neural modulation may be used, for example, to modulate an undesired sensation, such as pain. Delivery of stimuli for modulating neural activity may be controlled in part in based on an activity state of the subject.

A hand-held device for electrically powered skin treatment includes a housing which is adapted to be grasped by a hand of a user, a first outer electrode which is adapted to be in contact with the hand of the user when the device is held in the hand of the user for use, a second outer electrode disposed on a side of the housing where the second outer electrode is placeable on an area of skin to be treated, and an electrically operated vibrator where the electrically operated vibrator is fixed by a socket on a side wall of the housing and is adapted to vibrate the side wall together with the second outer electrode when operated so that during operation of the device, the device produces an intensified massaging effect on the area of skin to be treated.

A system and method for testing of skin electroporation using simulations of human skin has been described. The system is using a simulation protocol to provide an in-silico design of skin's upper layer stratum-corneum (SC) at molecular level. This model is then further used to design the skin electroporation strategy. An external electric field was applied across the lipid bilayer to form a pore in the lipid bilayer. The pore size and pore growth rate was calculated depending on the applied external electric field. The generated pore was then stabilized by varying the external electric field. Further, on removing the external electric field, the reformation of lipid bilayer and self-healing of human skin was also achieved. In another embodiment, the system is also configured to perform the virtual testing of a drug permeation through skin in presence of external electric field.