A method for photothermolysis that includes applying galvanic current energy to skin at an area of a hair follicle and applying pulsed optical energy to the skin at the area of the hair follicle at an energy level and duration so as to cause thermal destruction of a hair papilla.

Electroporation devices and methods of making the same. An electroporation device includes a plurality of independently controllable or addressable electrode pairs, a plurality of reaction chambers, each reaction chamber including a first chamber, a second chamber and a porous substrate separating the first chamber from the second chamber, and each reaction chambers being disposed between one of the plurality of independently controllable or addressable electrode pairs, a plurality of first microfluidic channels configured to deliver a cargo solution from a cargo inlet port to the plurality of first chambers, and a plurality of second microfluidic channels configured to deliver a cell culture from a cell inlet port to the plurality of second chambers. In operation, application of a voltage to an electrode pair permeabilizes the membranes of the cells adhered to the porous substrate in the reaction chamber disposed between the electrode pair.

Catheter systems and methods for the selective and rapid application of DC voltage to drive irreversible electroporation are disclosed herein. In some embodiments, an apparatus includes a voltage pulse generator and an electrode controller. The voltage pulse generator is configured to produce a pulsed voltage waveform. The electrode controller is configured to be operably coupled to the voltage pulse generator and a medical device including a series of electrodes. The electrode controller includes a selection module and a pulse delivery module. The selection module is configured to select a subset of electrodes from the series of electrodes. The selection module is configured identify at least one electrode as an anode and at least one electrode as a cathode. The pulse delivery module is configured to deliver an output signal associated with the pulsed voltage waveform to the subset of electrodes.

A wearable device combines its existing functions (e.g., a headphone) with non-invasive autonomic modulation using tragus or other external auditory meatus stimulation. The wearable device can output audio to a user, such as music, podcast, etc., and further provide modulation of the vagus nerve via tragus stimulation or other external auditory meatus stimulation to treat various diseases.

A system and method of controlling electrotransfer delivery of therapeutic molecules to targeted groups of cells. The system has an array of two or more physically contiguous electrodes configured to be inserted into biological tissue and a pulse generator configured to selectively drive the two or more electrodes as one or more anodes and one or more cathodes for application of electrical pulses. The physical configuration of the electrodes, selection of electrodes and anodes and cathodes, and applied electrical pulse parameters, control contours of gradients within the electric field for the target treatment region adjacent the array. A first selection of electrodes to drive as anodes and cathodes using one or more electric pulses is determined, and or the selected electrodes, electrical pulse parameters for one or more electric pulses to generate a first shaped electric field for a target treatment region adjacent the array are determined. A second selection of electrodes to drive as anodes and cathodes using one or more electric pulses is determined, and for the selected electrodes, electrical pulse parameters are determined for the one or more electric pulses to generate a second shaped electric field for a target treatment region adjacent the array. The pulse generator is controlled to apply a first sequence of one or more unipolar pulses using the first selection of electrodes driven as anodes and cathodes to generate a first shaped electric field, and a second sequence of one or more unipolar pulses using the second selection of electrodes driven as anodes and cathodes to provide a second shaped electric field.

Methods and related systems for modulating neural activity by cyclically modulating neural activity in peripheral neural structures are disclosed. Neural activity may be modulated cyclically by stimuli delivered via various types of stimulus sources. In an aspect, activity of a sensory nerve is modulated. Neural modulation may be used, for example, to modulate an undesired sensation, such as pain, or an immune or inflammatory response or process. Delivery of stimuli for modulating neural activity may be controlled in part in response to an input from a user input device.

The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.

The present invention relates to apparatus for topical application of material for cosmetic purposes (10). The apparatus for topical application of material (10) comprises measurement apparatus configured to measure a property of skin of a human or animal subject and actuating apparatus configured to change a permeability of the skin of the human or animal subject in dependence on the measured property of the skin. The apparatus for topical application of material (10) further comprises application apparatus configured to apply material for cosmetic purposes to the skin whilst substantially no iontophoretic current flows through the skin and after the permeability of the skin has been changed.

The subject of the invention is a microprobe for selective electroporation comprising at least two metal electrodes (A) immersed in a glass rod (E), characterised in that the glass rod (E) made of a primary glass is 50 μm to 2 mm in diameter, preferably 50 μm to 500 μm, the metal electrodes (A) made of a metal alloy are formed as rods with diameter of 1 μm to 100 μm, preferably 20 μm to 30 μm, wherein endings of those rods are exposed, wherein the primary glass and the metal alloy are matched in such manner that dilatometric softening temperature DTM of the primary glass is highly similar to the temperature of melting for the metal alloy.
The invention also includes a method of manufacturing of such a microprobe.

A patch for a therapeutic electrical stimulation device includes a shoe connected to the first side of the patch, the shoe including a body extending in a longitudinal direction from a first end to a second end, and having first and second surfaces, the first end of the shoe defining at least two ports, and the first surface of the shoe defining a connection member. The patch also includes at least one conductor positioned in the ports of the first end of the shoe. The shoe is configured for sliding insertion into a receptacle defined by a controller so that the conductor is connected to the controller to deliver electrical current from the controller, through the conductor, and to the electrodes, and the connection member is at least partially captured by a detent defined by the controller in the receptacle to retain the shoe within the receptacle.