A headset for ocular dermal therapy is used for one or more of reducing dark eye circles, rejuvenating eyelid skin, boosting micro circulation, enhancing transdermal eye serum adsorption, reduction of allergy related skin conditions around the islands, improving skin tone, eye muscle relaxation and stress relief. The headset has a pair of periorbital contact eye pads which are controlled by a controller to administer ocular dermal therapy to the skin of the eyelids and surrounding the eye.

The present disclosure relates generally to electroporation systems and utilizing algorithms for electroporation pulse delivery including a patient's EKG/EGM monitoring. In some embodiments, an electroporation delivery system may include an electrocardiogram operatively connected to a processing device and a memory. One or more sensors may be operatively connected to the electrocardiogram for measuring electrical activity QRS complex of a patient's heart. One or more electrodes for treatment may be disposed in, at, or near the patient's heart, the one or more electrodes operatively connected to a pulse delivery mechanism. The electroporation delivery system may be configured to determine whether an electroporation pulse is deliverable to a patient based on the electrocardiogram.

A system and method for testing of skin electroporation using simulations of human skin has been described. The system is using a simulation protocol to provide an in-silico design of skin's upper layer stratum-corneum (SC) at molecular level. This model is then further used to design the skin electroporation strategy. An external electric field was applied across the lipid bilayer to form a pore in the lipid bilayer. The pore size and pore growth rate was calculated depending on the applied external electric field. The generated pore was then stabilized by varying the external electric field. Further, on removing the external electric field, the reformation of lipid bilayer and self-healing of human skin was also achieved. In another embodiment, the system is also configured to perform the virtual testing of a drug permeation through skin in presence of external electric field.

The disclosure is directed to a device for electroporating and delivering one or more antigens and a method of electroporating and delivering one or more antigens to cells of epidermal tissues using the device. The device comprises a housing, a plurality of electrode arrays projecting from the housing, each electrode array including at least one electrode, a pulse generator electrically coupled to the electrodes, a programmable microcontroller electrically coupled to the pulse generator, and an electrical power source coupled to the pulse generator and the microcontroller. The electrode arrays define spatially separate sites.

A hand-held device for electrically powered skin treatment includes a housing which is adapted to be grasped by a hand of a user, a first outer electrode which is adapted to be in contact with the hand of the user when the device is held in the hand of the user for use, a second outer electrode disposed on a side of the housing where the second outer electrode is placeable on an area of skin to be treated, and an electrically operated vibrator where the electrically operated vibrator is fixed by a socket on a side wall of the housing and is adapted to vibrate the side wall together with the second outer electrode when operated so that during operation of the device, the device produces an intensified massaging effect on the area of skin to be treated.

A system for cosmetically treating a patient's skin or body with one or more EMS coils and/or RF electrodes mounted on a planar holder; a hydrogel containing gel pad, the gel pad being positionable between the holder and the skin tissue; wherein the gel pad being of a material that is biocompatible and conducts RF and/or EMS energy when EMS energy is applied from the one or more EMS coils; a programmable controller to activate the one or more EMS coils; the programmable controller, after the planar holder is applied to the skin tissue, being configured to activate one or more of the plurality of EMS coils to provide treatment in the form of stimulation to the skin tissue.

The present disclosure relates generally to electroporation systems and utilizing algorithms for electroporation pulse delivery including a patient's EKG/EGM monitoring. In some embodiments, an electroporation delivery system may include an electrocardiogram operatively connected to a processing device and a memory. One or more sensors may be operatively connected to the electrocardiogram for measuring electrical activity QRS complex of a patient's heart. One or more electrodes for treatment may be disposed in, at, or near the patient's heart, the one or more electrodes operatively connected to a pulse delivery mechanism. The electroporation delivery system may be configured to determine whether an electroporation pulse is deliverable to a patient based on the electrocardiogram.

A wearable device combines its existing functions (e.g., a headphone) with non-invasive autonomic modulation using tragus or other external auditory meatus stimulation. The wearable device can output audio to a user, such as music, podcast, etc., and further provide modulation of the vagus nerve via tragus stimulation or other external auditory meatus stimulation to treat various diseases.

Presented herein are techniques that enable electroporation of the cells of a recipient of a tissue-stimulating prostheses while the tissue-stimulating prosthesis is implanted in the recipient. Tissue-stimulating prostheses in accordance with embodiments presented herein are configured such that the stimulation electronics (e.g., current sources and integrated circuit) of the prosthesis are not exposed to the high voltages used in electroporation.

A high voltage pulse generator for electro-poration comprising: a capacitor bank in which the electric charge used to generate the pulses is stored; the capacitor bank has an output terminal on which a high voltage direct current HT is present; a voltage amplifier circuit which receives, at input, the high voltage direct current HT and is provided with an automatic gain control circuit designed to compare a reference voltage V.sub.HT-ref with the voltage supplied at output V.sub.OUT by the amplifier to maintain the voltage constant at output during generation of the pulses; a current amplifier circuit arranged downstream of the voltage amplifier circuit and provided with an electronic semiconductor switch communicating with a first terminal with the output of the capacitor bank and provided with a second terminal designed to communicate with an output of the pulse generator; the voltage present at the output of the voltage amplifier is supplied to the output of the pulse generator and is used to operate the switching during closing of the electronic semiconductor switch.