Electromechanical substance delivery devices are provided which implement low-power electromechanical release mechanisms for controlled delivery of substances such as drugs and medication. For example, an electromechanical device includes a substrate having a cavity formed in a surface of the substrate, a membrane disposed on the surface of the substrate covering an opening of the cavity, and a seal disposed between the membrane and the surface of the substrate. The seal surrounds the opening of the cavity, and the seal and membrane are configured to enclose the cavity and retain a substance within the cavity. An electrode structure is configured to locally heat a portion of the membrane in response to a control voltage applied to the electrode structure, and create a stress that causes a rupture in the locally heated portion of the membrane to release the substance from within the cavity.

An adaptive transdermal iontophoretic introduction system for the beauty field is provided. Specifically, the system includes an iontophoretic introduction system, and a control and drive electronic system. The control and drive electronic system includes an operation system, a central processing system, an electrode drive system, a sensing system and a data communication system. The adaptive transdermal iontophoretic introduction system provides personalized transdermal drug delivery according to the actual condition of a user's skin, optimizes the dose, depth and speed of the transdermal drug delivery in real time, and maximizes the product usage effect and safety.

A handheld sinus treatment device provides sinus relief treatment to a user. The handheld sinus treatment device includes a wireless receiver configured to receive wireless signals including control data from a handheld personal electronic device. The user positions a treatment electrode of the handheld sinus treatment device at a treatment location on the user's face corresponding to a sinus nerve node. The handheld sinus treatment device provides electrical sinus treatment stimulation in accordance with the control data.

A microcurrent treatment device includes an adaptive trigger circuit configured to dynamically determine a triggering threshold for applying a therapeutic microcurrent via a treatment electrode to a nerve node on a person's face for treatment of a sinus condition.

The disclosure relates to a flexible active species generator comprising: a first electrode of a conductive metal thin film; a second electrode of a ground electrode; a flexible dielectric layer of an insulator formed between the first electrode and the second electrode; and a plasma resistant functional layer formed between the dielectric layer and the second electrode, wherein the first electrode and the second electrode are electrically connected to an external power supply to generate an atmospheric pressure plasma to generate active species. The flexible active species generator has a plasma resistant function to prevent deformation and decomposition of an insulator caused by the plasma as well as an active species generating function from atmospheric pressure plasma, and has durability and safety, which is thus applicable to articles, foods, garments and human body in various forms.

A transdermal delivery system (1) configured to deliver an active agent to human or animal tissue, comprising a penetrative electrode (2) of one polarity that provides an electrical contact (3) beneath the stratum corneum (20); a surface electrode (4) of the opposite polarisation to that of the penetrative electrode (2) that provides an electrical contact to the external surface of the skin (21) on the opposite side of the stratum corneum (20) to the electrical contact (3) of the penetrative electrode (2); a dispenser (5) configured to deliver of an active agent to the external surface of the skin (21) adjacent to an electrical contact of the surface electrode (4); a method of delivering the active agent to the tissue of a human or animal body using the transdermal delivery system (1) and an electrode assembly (10) for use in preparing the transdermal delivery system (1).

An oral appliance for the treatment of sleep disorders, such as obstructive sleep apnea, in a user is presented. The oral appliance may include a mouthpiece configured to receive a user's dentition. The mouthpiece may include an oxygen sensor, a pressure sensor, an airflow sensor, an actigraphy sensor, a noise detector, and at least one stimulator for providing stimulation to a user's tongue in the event of decreased oxygen saturation levels, increased pressure applied to occlusal surfaces of the user's dentition, decreased actual airflow levels and/or increased noise levels. The mouthpiece may be provided with pharmaceutical compound reservoirs that deliver pharmaceutical compounds to the oral mucosa of the user, which compounds treat symptoms of sleep apnea. The mouthpiece may further include a microprocessor that receives data from the oxygen sensor, pressure sensor, airflow sensor, actigraphy sensor and noise detector, and activates the at least one stimulator and/or pharmaceutical compound reservoirs.

A device for the cosmetic treatment of keratin materials with an electric current, including: a current generator (1), a reservoir (3) containing a cosmetic composition (P), an end piece (2) comprising an electrode (4) and at least one applicator member (6, 7), said applicator member (6, 7) delimiting an outer wall (61, 71) that is able to be filled with product contained in the reservoir (3), a counter electrode (5), a system for regulating the quantity of composition (P) exiting the reservoir (3) on the basis of the impedance measured between the electrode (4) and the keratin materials, the electrode (4) and the applicator member (6, 7) being designed such that the composition (P) is the only conductive substance in contact with the skin while the device is being used.

A sweat sensor device (200) includes one or more sweat sensors (220) and a seal (280) covering the one or more sweat sensors (220). The seal (280) is adapted to protect the sweat sensors (220) from outside contaminants when the device (200) is placed on the skin (12). The sweat sensor device (200) may include an absorbing medium (230) to absorb sweat from the skin (12) that is covered by the seal (280). The seal (280) can be permeable to gas, permeable to water and impermeable to at least one aqueous solute, or selectively permeable to at least one aqueous solute. The sweat sensor device (200) may include an artificial sweat stimulation mechanism (345) for stimulating sweat when the device (200) is placed on the skin (12).

The present technology includes systems and methods for treating pain by pulsing heat into a volume of tissue containing thermoreceptors. The pulsed heat may be configured to induce stimulation of thermoreceptors. The pulsed heat may also be applied at a frequency configured to induce desensitization of at least a subset of the thermoreceptors.