A multichannel stimulation system for regenerating damaged corneal nerves, includes: electrically contacting a contactor of the multichannel unit with the stimulation signal module; providing an electric pulse signal, by the stimulation signal module; transferring an electric pulse signal of a first duration time and an electric pulse signal of a seventh duration time to the first channel, and transferring an electric pulse signal; maintaining an adjusted magnitude of the absolute value of an electric pulse signal when the magnitude of the absolute value of the electric pulse signal desired by a user is adjusted; and confirming whether impedance measured between the first channel and an area where the first channel is attached and impedance measured between the second channel and an area where the second channel is attached exceed a reference impedance.

Described is a low voltage, pulsed electrical stimulation device for controlling expression of klotho, a useful protein, by tissues. Also described are methods of enhancing expression of klotho in cells.

A device and a method for stimulating skin regeneration is described which allows exploiting the combined action of the surface vasculature (given by the action of the vacuum) and of the cellular regeneration (given by the electromagnetic field generated by a capacitive system) combined with the skin electrostimulation applied, in this case, so as to amplify the biological effect of the electromagnetic field.

A system and method for pulsed electromagnetic fields (PEMF) tissue engineering enhances musculoskeletal tissue stimulation. A tissue engineering device may include both low and high pulse frequency signal generation components that may alternatively drive one or more coils to generate PEMFs. These PEMFs may be applied to bone tissue, tendons, ligaments, and/or cartilage. A prescribed treatment regimen using the tissue engineering device may include a first period of time where a first pulse frequency is used in treatment that supports tissue proliferation followed by a second period of time where a second pulse frequency (less than the first pulse frequency) is used in treatment that supports tissue differentiation. A treatment regimen may also include, with the frequency characteristic, applying a slew rate to the pulse characteristics that is on the order of around 30 to 100 Tesla per second to drive tissue differentiation in a targeted manner.

Improved in vivo brain therapy is provided with a system having a neural implant that delivers both electrical stimulation and stem cell therapy to the brain. The return electrode for electrical stimulation is spaced apart from the implant to prevent local short-circuiting of the electrical stimulation. After forming the implant, stem cells can be seeded upon it, and subsequently, the apparatus can be implanted in vivo. A cannula system allows for continued electrical stimulation and the ability to manipulate the stem cells within the host environment.

An apparatus includes multiple first reservoirs and multiple second reservoirs joined with a substrate. Selected ones of the multiple first reservoirs include a reducing agent, and first reservoir surfaces of selected ones of the multiple first reservoirs are proximate to a first substrate surface. Selected ones of the multiple second reservoirs include an oxidizing agent, and second reservoir surfaces of selected ones of the multiple second reservoirs are proximate to the first substrate surface.

An electrode head is disclosed that utilizes electrically conductive or dissipative fabric to exchange electrical energy with tissue. This electrode head may be used for any appropriate application, such as a catheter electrode, a return electrode, or the like. Any appropriate function may be provided by this electrode head, such as tissue ablation, tissue mapping, or providing an electrical ground.

An apparatus includes multiple first reservoirs and multiple second reservoirs joined with a substrate. Selected ones of the multiple first reservoirs include a reducing agent, and first reservoir surfaces of selected ones of the multiple first reservoirs are proximate to a first substrate surface. Selected ones of the multiple second reservoirs include an oxidizing agent, and second reservoir surfaces of selected ones of the multiple second reservoirs are proximate to the first substrate surface.

A system and method for pulsed electromagnetic fields (PEMF) tissue engineering enhances musculoskeletal tissue stimulation. A tissue engineering device may include both low and high pulse frequency signal generation components that may alternatively drive one or more coils to generate PEMFs. These PEMFs may be applied to bone tissue, tendons, ligaments, and/or cartilage. A prescribed treatment regimen using the tissue engineering device may include a first period of time where a first pulse frequency is used in treatment that supports tissue proliferation followed by a second period of time where a second pulse frequency (less than the first pulse frequency) is used in treatment that supports tissue differentiation. A treatment regimen may also include, with the frequency characteristic, applying a slew rate to the pulse characteristics that is on the order of around 30 to 100 Tesla per second to drive tissue differentiation in a targeted manner.

A stimulation device includes an adaptor component. The adaptor component couples a percutaneous lead to the stimulation device. The stimulation device may apply a stimulation signal to target tissue via the adaptor. A surgeon may place the stimulation device in a container and the adaptor component may be disposed outside of the container. Methods describe prolonged stimulation of target tissue via a stimulation device. The prolonged stimulation may be applied during and after a surgical procedure.