A device for promoting healing of an injury in a living being is provided. Such device is based upon an injury covering portion, which portion comprises an electroactive polymer, such as poled polyvinylidine difluoride (PVDF) or a copolymer of PVDF. The electroactive polymer has either pyroelectric properties, piezoelectric properties, or both.

A kit of parts for use in treatment of tissue by a contained plasma and/or plasma products is disclosed. The kit of parts includes a plasma generating device for use with a membrane dressing attached to tissue requiring treatment. The plasma generating device comprises a first cavity with an opening at one end formed between a grounded electrode and a cathode such that, in use, an arc discharge between the cathode and the grounded electrode ionizes a feed gas to produce at the open end a thermal plasma. Furthermore, the plasma generating device also comprises a second cavity with an opening at one end formed between a high voltage electrode and a grounded electrode such that, in use, a dielectric barrier discharge between the high voltage electrode and grounded electrode ionizes a feed gas to produce at the open end a non-thermal plasma. The membrane dressing is suitable for covering tissue in use, such as a diabetic ulcer, and comprises a sheet of impermeable material configured for forming a plasma containment compartment adjacent to the tissue. The membrane dressing also comprises one or more input connectors configured to admit plasma and/or plasma products through the membrane dressing. The plasma generating device and the one or more input convectors of the membrane dressing are configured to allow the plasma generating device and the input connector to be directly coupled or indirectly coupled through a connector tube to allow fluid communication of the plasma and/or plasma products produced at the openings of the cavities of the plasma generating device through the membrane dressing to, in use, allow conduction of the produced plasma into the membrane dressing. Advantages of such a kit of parts may be that the membrane dressing does not need to be removed to inspect the progress of the wound, nor does it need to be removed and replaced to manage the exudate. Such advantages helps to mitigate the problems of wound aggravation and maceration typically associated with well-known wound dressings, and also helps to encourage and facilitate wound healing.

The invention provides a variety of novel devices, systems, and methods of utilizing mixed-ionic-electronic conductor (MIEC) materials adapted to function with an applied current or potential. The materials, as part of a circuit, are placed in contact with a part of a human or nonhuman animal body. A sodium selective membrane system utilizing the MIEC is also described.

The invention provides a variety of novel devices, systems, and methods of utilizing mixed-ionic-electronic conductor (MIEC) materials adapted to function with an applied current or potential. The materials, as part of a circuit, are placed in contact with a part of a human or nonhuman animal body. A sodium selective membrane system utilizing the MIEC is also described.

An apparatus for treating venomous bites and stings of poisonous snakes, insects and other types of poisonous vectors with a titrated dose of electrons. The unit is small and easily portable and requires on a 9-vold DC battery for power. It does not require a lot of expertise to use. A bi-metallic switch provides for a limited (and calculated) dose delivery of electrons. The venom desensitizer destabilizes and de-organizes toxic metalloproteinases. This occurs through several physiological and chemical phenomena. It addresses oxidative stress occurring from bite trauma as well as venom toxins without causing negative side effects other than a brief electrical shock.

Generally discussed herein are systems, devices, and methods for providing a therapy (e.g., stimulation) and/or data signal using an implantable device. Systems, devices and methods for interacting with (e.g., communicating with, receiving power from) an external device are also provided.

Disclosed are methods, devices, and systems for treatment of an abnormal wound healing response. The methods, devices, and systems can be used to treat solid ulcerated tissue, such as diabetic foot ulcers (DFUs), arthritic tissue, muscle soreness, joint pain, varicose veins, obesity, and peripheral artery disease. Additionally, the methods, devices, and systems can promote the healing of xenograft, allograft, autograft, or engineered tissue following reconstruction surgery. The methods, devices, and systems include the ability to determine an optimal set of pulse parameters that are specific to wound healing. In embodiments, the methods, devices, and systems include components for guiding the user on electrode placement based on anatomical or electrical measurements, delivering a custom series of electric pulses, applying heat, and using feedback from physiologic measurements to control the device.

A method for treating a wart on skin of a patient includes guiding non-thermal, atmospheric pressure plasma over areas of the tissue having the wart for a length of time effective to give rise to an at least partial amelioration of the wart.

A method and wearable system and for enhancing human balance and gait and preventing foot injury through neurological stimulation of the foot and the ankle. Subthreshold stimulation for neurosensory enhancement is provided via electrodes or vibrational actuators, or combination thereof, disposed in or on a wearable a platform, such as an insole, sock shoe, removable shoe insert, or applied without the support of a platform, to the skin surface of an individual. Suprathreshold stimulation for therapeutic purposes, such as improving blood flow, is also provided by the vibrational actuators. The actuators and electrodes are driven by bias signals generated by a bias signal generator that is coupled to a controller. The signal generator under the control of the controller is adapted to generate a non-deterministic random signal, a repetitive pattern or series of patterns. The controller optionally includes a communication port for interfacing with an external computer for purposes of optimizing and programming the controller. The wearable system is powered by a power source.

A bioelectric device includes multiple first reservoirs and multiple second reservoirs joined with a planar substrate. Selected ones of the multiple first reservoirs include a reducing agent, and first reservoir surfaces of selected ones of the multiple first reservoirs are proximate to a first substrate surface. Selected ones of the multiple second reservoirs include an oxidizing agent, and second reservoir surfaces of selected ones of the multiple second reservoirs are proximate to the first substrate surface.