Systems and methods for providing vibration and temperature therapy via a therapy device is disclosed. According to one embodiment, a therapy device includes a pad comprising an adhesive layer configured to adhere to a skin surface of a user. The therapy device includes a control unit coupled to the pad. The control unit is configured to provide temperature therapy to the skin surface of the user and provide vibration therapy to the skin surface of the user. The pad includes a coupling connector configured to removably couple the control unit. The pad can include a heat generation module comprising a resistive wire and a heat spreader. The pad can include one or more electrical stimulation modules, wherein each electrical stimulation module comprises a conductor and a pad. The pad includes a temperature sensor coupled to the heat generation module. The adhesive layer can be coupled to the heat spreader.

The present invention provides a thin and flexible device and method of use thereof for wound treatment and infection control. The integrated surface stimulation device may comprise wireless stimulation system in a disposable and/or reusable flexible device for widespread use in multiple therapeutic applications. The invention would be situated on the skin surface of a patient and would be activated so as to reduce the overall occurrence of infections and/or increase wound healing rates. As provided, the device will comprise an integrated power supply and pre-programmable stimulator/control system on a flexible polymeric substrate layer with areas of stimulating electrodes, applied using techniques such as those found in additive manufacturing processes. The device is especially valuable in treating biofilm-based infections.

A planar flexible electrode arrangement for a dielectric barrier plasma discharge has a central region (107) and an edge region (108) and at least one planar electrode (102) to which a high-voltage potential can be applied and which is embedded in a planar dielectric (101) that forms an upper face (103) and a contact face (104), wherein the planar dielectric (101), at least in the edge region (108), has the shape of a spiral-shaped wound-up strip (109) and the at least one electrode (102) is formed by at least one electrical conductor (114) that extends in the longitudinal direction of the wound-up strip (109) and that opens into an end face of the strip (109), which conductor (114) is surrounded, with the sole exception of the end face of the strip (109), by the dielectric of the strip (109) and, in the region of the end face of the strip (109), is electrically insulated from the surroundings by a cover element (116). The electrode arrangement can be adapted easily, and without tools, in its bearing surface to the size of the area of a surface that is to be treated, by virtue of the fact that material recesses (111) are present across the width of the strip (109), and that the material of the dielectric (101) and of the at least one conductor (114) is chosen such that the strip (109), together with the at least one conductor (114), can be torn off across its width along the material recesses (111).

A floating type plasma electrode pad includes the plasma electrode made of a conductive metal thin film, a flexible dielectric thin film layered on the plasma electrode, and made of a polymer material, the dielectric thin film being spaced apart from the skin by a predetermined distance such that microdischarge is generated in a space defined between the dielectric thin film and the skin, and a spacer layered on the dielectric thin film, to space the dielectric film from the skin by the predetermined distance.

The invention provides a variety of novel devices, systems, and methods of utilizing mixed-ionic-electronic conductor (MIEC) materials adapted to function with an applied current or potential. The materials, as part of a circuit, are placed in contact with a part of a human or nonhuman animal body. A sodium selective membrane system utilizing the MIEC is also described.

Described is a low voltage, pulsed electrical stimulation device for controlling expression of klotho, a useful protein, by tissues. Also described are methods of enhancing expression of klotho in cells.

Provided herein are systems, devices and methods for the treatment of fungus. In particular, provided herein are systems, devices and methods employing energy to nail and tissue structures to treat fungal infection.

This invention corresponds to an electrical and magnetic tissue stimulation device comprising a multi-source distribution circuit, a decoupled output stage circuit connected to the multi-source distribution circuit and to a control unit; the control unit is connected to the multi-source distribution circuit and to the decoupled output stage circuit, where the control unit generates PE and Out outputs for electrical and magnetic stimulation of a tissue. The invention also has a multi-source distribution circuit that comprises a control unit connected to a source output selector. A voltage regulator circuit is connected to a current limiter. The current limiter is connected to a capacitor, to a capacitor bank and to the source output sector, wherein the control unit controls the source output selector by means of an output control signal bus, the source output selector connects or disconnects one or more capacitors from the capacitor bank.

In a treatment arrangement for treating a surface, with a planar electrode array (2,2′), to which an electrical voltage can be fed, and with a planar shielding layer (1) which is made of an insulating plastic and which ate least partially surrounds the electrode array (2,2′), a reliable and fixed connection between the electrode array (2,2′) and shielding layer (1) is achieved by the fact that electrode array (2,2′) is made of a pourable plastic provided with plastic additives and that, in the region of a boundary layer (22) between electrode array (2,2′) and shielding layer (1), the plastics of the electrode array (2,2′) and of the shielding layer (1) are connected to each other by material bonding.

Disclosed are apparatuses and methods for reducing or limiting bleeding (e.g., blood loss and/or bleeding time) in an animal by trigeminal stimulation. The apparatuses and methods may activate one or more branches of the trigeminal nerve. This activation may be invasive or non-invasive.