There is disclosed an apparatus for treating a sexual dysfunctional female patient, comprising an implanted stimulation device adapted to stimulate at least a part of the sexually responsive tissue of the vulva or the wall of the vagina of the patient by movement of said stimulation device and contact between said stimulation device and the sexually responsive tissue or the wall of the vagina. A system and an operation method for the treatment of female sexual dysfunction are also disclosed.

A system and method are provided for performing predictive permeation on the skin of a patient, particularly where the skin has no corneum. For this purpose, a device is provided which has an elongated probe, with an electrode array that extends along an active segment of the probe. Also, a voltage source is connected to the electrode array to generate an electric field. Operationally, an electro-conductive emulsion is applied onto the skin of the patient where the predictive permeation procedure is to be performed and the probe is positioned to contact the skin to be treated. The emulsion then interacts with the electric field that is generated by the electrode array to increase the permeability of the skin. Particles from a blood sample of the patient are included in the emulsion, and are introduced into the skin during the predictive permeation procedure to increase skin density.

Methods for treating urinary stress incontinence by non-invasively delivering energy to one or more submucosal regions of vaginal tissue to induce remodeling within the vaginal tissue are provided. In some embodiments, the energy delivery results in heating of the target tissue to a temperature that ranges from about 38° C. to about 46° C. In some embodiments, the subject methods involve cooling a mucosal epithelial layer over the vaginal tissue. In some embodiments, a reverse thermal gradient is produced as the mucosal epithelium is cooled while energy is delivered to the underlying vaginal tissue.

An intravaginal electrical stimulation device for treating pelvic pain in a female patient comprises a set of intravaginal components and an external controller. The intravaginal components include a frame, at least one pair of paracervical electrodes embedded in the proximal portion of the frame, an intravaginal capsule, an electrode plug that plugs into a socket in the proximal end of the capsule, and connecting wires that electrically couple the electrode plug to the paracervical electrodes. The intravaginal components are designed to inserted into the patient's vagina so that the paracervical electrodes are in direct contact with the vaginal epithelium in the lateral vaginal fornices. Electronics, including a microprocessor and an electrical stimulation generator, are configured to generate and transmit low-voltage electrical current to the paracervical electrodes to create an electrical field that neuromodulates the pelvic and paracervical nerves, the nerves that innervate the uterus, and other anatomical structures of the lower pelvis, which tends to reduce or eliminate pelvic pain. The set intravaginal components are configured so that a woman can easily insert them into her vagina (with or without a medical practitioner being present). The external controller, which communicates with the intravaginal components over a wireless data communication channel, sends instructions to and receives status updates from the microprocessor inside the intravaginal capsule. The external controller may be operated by the female patient to control the electrical profile (e.g., frequency, amplitude and duration) of the electrical stimulation delivered to her body, and thereby cause the intravaginal components to deliver well-controlled, personalized, electrical stimulation to her pelvic and paracervical nerves when she is experiencing pain, or when she anticipates the onset of pelvic pain due to, for example, menstruation or sexual intercourse.

A device for providing fractional treatment of a body orifice includes a source of fractionated energy and a source of electrical muscle (EMS) energy. A programmed controller controls the application of fractionated and/or EMS energy. A probe is inserted by its distal end into the body orifice. The source of fractionated energy is positioned for transmitting fractionated energy from the source of fractionated energy through the probe to tissue in the vicinity around the body orifice; and, the source of EMS is positioned for transmitting EMS energy from the source of EMS energy through the probe to tissue in the vicinity around the body orifice. The programmed controller is configured to control the activation of fractionated energy and EMS energy one of simultaneously or sequentially.

In an aspect of the present disclosure, a system and method for controlling uterine contractions is disclosed including receiving data from at least one sensor by a wireless apparatus inserted into the patient's vagina adjacent the cervix. The data includes an indication that a contraction of the uterus is imminent. The method further includes in response to receiving the data, causing a generator circuit of the wireless apparatus to supply electrical energy to an energy applicator of the wireless apparatus that is configured to apply the supplied electrical energy to the uterus of the patient via the cervix of the patient to control contractions of the patient's uterus.

The systems and methods described herein generally relate to adjusting a neurostimulation (NS) therapy based on drug pharmacokinetics of a patient. The systems and methods deliver an NS therapy to a portion of electrodes of a lead positioned proximate to neural tissue of interest, which is associated with a target region. The NS therapy is defined by stimulation parameters. The systems and methods determine a trigger event indicative of a drug being administered to a patient. The drug is configured to affect at least one of the neural tissue of interest or the target region. The systems and methods adjust one or more of the stimulation parameters based on the PS profile.

In an aspect of the present disclosure, a system and method for controlling uterine contractions is disclosed including receiving data from at least one sensor by a wireless apparatus inserted into the patient's vagina adjacent the cervix. The data includes an indication that a contraction of the uterus is imminent. The method further includes in response to receiving the data, causing a generator circuit of the wireless apparatus to supply electrical energy to an energy applicator of the wireless apparatus that is configured to apply the supplied electrical energy to the uterus of the patient via the cervix of the patient to control contractions of the patient's uterus.

Methods for effectuating ovarian denervation include advancing a disruptor intravaginally to access an ovarian nerve and applying the disruptor to the ovarian nerve to denervate the ovarian nerve to limit ovarian sympathetic neural activity and control hormonal secretion.

A transvaginal stimulation device comprises a probe body sized to fit entirely within a vaginal cavity of a female patient. The probe body has a stimulating side defined by a length and a width of the probe body. The transvaginal stimulation device further comprises a pair of electrodes disposed on the stimulating side of the probe body and laterally spaced from each other. A method for treating stress urinary incontinence in a female patient comprises inserting the intravaginal device into a vaginal cavity of the female patient, positioning the pair of electrodes against an anterior wall of the vagina of the female patient, and conveying stimulation energy between the pair of electrodes to stimulate at least one muscle of a urethral sphincter muscle of the female patient without substantially stimulating pelvic floor muscles of the female patient.