An electromedical adapter, an electromedical electrode and an electromedical pulse generator are provided for the field of medical electrical stimulation. In order to connect a non-coiled electrode portion (3) to a coiled electrode portion (2), in particular the adapter (1) is provided, having at least one contact element (5) which can be contacted by a coiled electrode portion (2) of an electrode (4) in such a way that the coiled electrode portion (2) surrounds, i.e. radially surrounds, a longitudinal axis of the main body (7) of the adapter with the at least one coiled conductor (8) thereof.

Amyloid fibers-based electrodes and apparatuses comprising the same. Additionally, methods for manufacturing amyloid fibers-based electrodes.

An implantable device is provided, comprising: a substrate; an integrated circuit attached to the substrate; and an ultrasonic transducer configured to receive ultrasonic waves that power the integrated circuit, wherein the ultrasonic transducer is attached to the substrate via one or more electrodes, and wherein the total electrode surface area in contact with the ultrasonic transducer is smaller than the surface area of a face of the ultrasonic transducer to which the one or more electrodes are attached. For example, the ultrasonic transducer may be a cubic piezoelectric crystal, and the electrodes may be positioned at the edges of a face of the cubic piezoelectric crystal, at the center of a face of the cubic piezoelectric crystal, or at the corners of a face of the piezoelectric crystal.

One embodiment of the present invention provides a flexible neural electrode having improved adherence to an object by using a three-dimensional structure. A neural electrode based on the three-dimensional structure of a flexible substrate, according to one embodiment of the present invention, comprises: a first polymer layer, which is formed from a polymer material, is flexible, and functions as a base; at least one photoresist part, which is formed on one portion of the surface of the first polymer layer and forms a three-dimensional structure; a second polymer layer which is formed on the photoresist part and the rest of the surface of the first polymer layer, and which comprises protrusion parts caused by the photoresist part; a metal thin film layer formed by patterning a metal thin film on the surface of the second polymer layer and the surface of the protrusion parts; and a third polymer layer which is formed on the surface of the second polymer layer and the metal thin film layer so as to function as a covering, and which comprises measurement holes formed so that one portion of the metal thin film layer formed at the ends of the protrusion parts is exposed to the outside.

An interface structure for a biological environment including at least one composite electrical impulse generating layer comprising a matrix phase of a piezo polymer material, a first dispersed phase of piezo nanocrystals, and second dispersed phase of carbon nanotubes, the first and second dispersed phase presented through the matrix phase. The piezo polymer material and piezo nanocrystal convert mechanical motion into electrical impulses and accept electrons to charge the composite impulse generating layer. The carbon nanotubes provide pathways for distribution of the electrical impulses to a surface of the composite impulse generating layer contacting the biological environment. The carbon nanotubes further provide for the delivery of the byproducts of the free radical degradation from the biological environment to both piezo-nanocrystals and piezo-polymer.

This disclosure describes the methods, devices, and systems of treating diseased tissue with integrated nanosecond pulse irreversible electroporation. Methods and systems as disclosed provide MRI compatible shielded electrodes and electrode leads to prevent emanating radiofrequency noise and improve image quality, disconnecting the electrode from the cable linkage to the pulse generator reduce electromagnetic interference and image artifacts, placing electrodes strategically within a guide cannula to minimize distortion from heterogeneities or maximize ablation within the tissue, utilizing conductive fluids, innate or external, such as cerebral spinal fluid or grounding pads to provide a pathway for current return, and for timing of the electrical waveforms with inherent brain electrical activity.

An insertion device is proposed for implanting a flexible implantable strip in the cortex of a living being in a reliable and accurate manner. The insertion device comprises a wire maintained within a lumen of a penetration member so that a free tip portion configured to engage an anchoring hole of the implantable strip protrudes from a distal end of the penetration member Thanks to reduced dimensions of the tip portion of the wire compared to that of the implantable strip, removing the wire from the lumen results in the implantable strip being released from the penetration member while still adhering to the cortex. The wire may be withdrawn by pulling at an end portion opposite to the tip portion. The penetration member can be chosen among a needle and a tube

A neurostimulation system senses electrographic signals from the brain of a patient, extracts features from the electrographic signals, and when the extracted features satisfy certain criteria, detects a neurological event type. A mapping function relates the detected neurological event type to a stimulation parameter subspace and a default stimulation parameter set where the values of the stimulation parameters define an instance of stimulation therapy for the patient. The decision whether to implement a stimulation parameter subspace or a default stimulation parameter set may be informed by integrating other information about a state of the patient. A stimulation parameter subspace or stimulation parameter set may optimized by testing it against various thresholds until certain effectiveness criteria is satisfied. The neurological event type may be one of several electrographic seizure onset types.

Disclosed herein are improved neural depth probes for detection and stimulation, along with various related improved components, devices, methods, and technologies. More specifically, the devices are layered depth electrodes with at least two layers, with each of the layers containing at least one thin-film trace disposed thereon. Each of the devices can also have a plurality of layers with at least two traces on each layer and contacts coupled to each trace.

Cortical network structure that mediates response to brain stimulation, and associated systems and methods are disclosed herein. In one embodiment, a method for brain stimulation includes: delivering an input stimulus to an area of the brain, via a cortical implant; in response to delivering the input stimulus, generating neural signals in the brain; and generating a predicted outcome of the input stimulus. The predicted outcome is based on a set of data derived from a model that combines: protocol features that are brain agnostic, and network features that are based on interactions between neural nodes of the brain.