Described here are devices, systems, and methods for treating one or more conditions (such as dry eye) or improving ocular health by providing stimulation to nasal or sinus tissue. Generally, the devices may be handheld or implantable. In some variations, the handheld devices may have a stimulator body and a stimulator probe having one or more nasal insertion prongs. When the devices and systems are used to treat dry eye, nasal or sinus tissue may be stimulated to increase tear production, reduce the symptoms of dry eye, and/or improve ocular surface health.

An embodiment herein relates to a wearable device comprising three strips of medical-grade, hypoallergenic adhesive wherein two of the strips lie above and below the mouth, and the third strip connects the first two and bridges the gap across the lips, keeping them closed. The strips are connected by hook and loop attachments, allowing them to be removed and reattached as needed when used. The wearable device may have additional features, included but not limited to being reusable, containing electrodes to stimulate muscles, various sensors, a handheld device, added ointment or skin-absorbed medication, a nasal dilator, different colors, and/or cloth padding for added comfort.

Systems, apparatus, and methods are described for delivering a therapeutic substance to a target area within or proximate to a nasal cavity of a subject, including a reservoir configured to contain the therapeutic substance and a delivery interface by which the therapeutic substance is delivered to the target area. In some embodiments, systems, apparatus, and methods described herein can deliver a therapeutic substance using iontophoresis and/or electroosmosis.

Devices for therapeutic nasal neuromodulation and associated systems and methods are disclosed herein. A system for therapeutic neuromodulation in a nasal region configured in accordance with embodiments of the present technology can include, for example, a shaft and a therapeutic element at a distal portion of the shaft. The shaft can locate the distal portion intraluminally at a target site inferior to a patient's sphenopalatine foramen. The therapeutic element can include an energy delivery element configured to therapeutically modulate postganglionic parasympathetic nerves at microforamina of a palatine bone of the human patient for the treatment of rhinitis or other indications. In other embodiments, the therapeutic element can be configured to therapeutically modulate nerves that innervate the frontal, ethmoidal, sphenoidal, and maxillary sinuses for the treatment of chronic sinusitis.

Described here are devices, systems, and methods for treating one or more conditions (such as dry eye) or improving ocular health by providing stimulation to nasal or sinus tissue. Generally, the devices may be handheld or implantable. In some variations, the handheld devices may have a stimulator body and a stimulator probe having one or more nasal insertion prongs. When the devices and systems are used to treat dry eye, nasal or sinus tissue may be stimulated to increase tear production, reduce the symptoms of dry eye, and/or improve ocular surface health.

According to an embodiment, a microcurrent sinus treatment device includes a hand holdable case configured to substantially contain active portions of a circuit for applying a sequence of voltage pulses to nerve nodes near the sinuses of a user. The hand holdable case includes a forward end terminating in a therapeutic electrode, and a return electrode comprising a portion of or disposed on a surface of the hand holdable case. The hand holdable case includes a dielectric spacer disposed between the therapeutic electrode and the return electrode, and a rearward portion of the hand holdable case terminating at an end a distance less than about four inches from the therapeutic electrode tip. The dielectric spacer and the return electrode may form a tapered surface narrowing toward the therapeutic electrode from a point of maximum girth disposed between the forward end and the rearward end of the hand holdable case.

Presented herein are systems, methods, and techniques related to delivery of simulated flavor sensations to a user while consuming (e.g., eating, drinking) food items. The perception of flavor is a multisensory experience as it involves not only taste, but other sensory experiences such as sight, sound, smell, and touch. Delivery of one or more sensory experiences to a user as the user is consuming a food item is able to augment how the user experiences the food item's flavor. For example, changing a smell or color a food item has affects how users perceive it when being consumed Changing perceptions through stimulating various senses can alter expectations significantly and in unexpected ways when delivering or combining stimuli. Accordingly in some embodiments, the present disclosure provides for technologies (e.g., device(s), systems and/or method(s)) for delivering simulated flavor sensations while consuming food items (e.g., solid food items, a beverage).

Described herein are polymer formulations for facilitating electrical stimulation of nasal or sinus tissue. The polymer formulations may be hydrogels that are prepared by a UV cross-linking process. The hydrogels may be included as a component of nasal stimulator devices that electrically stimulate the lacrimal gland to improve tear production and treat dry eye. Additionally, devices and methods for manufacturing the nasal stimulators, including shaping of the hydrogel, are described herein.

Described here are devices, systems, and methods for treating one or more conditions, such as allergic rhinitis, non-allergic rhinitis, nasal congestion, ocular allergy, and/or symptoms associated with these conditions, by providing stimulation to nasal or sinus tissue. In some variations, the handheld devices may have a stimulator body and a stimulator probe having one or more nasal insertion prongs, and the nasal insertion prongs may be configured to deliver an electrical stimulus to the tissue.

Described herein are devices and methods of use thereof for treating dry eye, tired eye, or other forms of ocular discomfort such as from contact lenses. The methods generally include applying spatially and/or temporally patterned stimulation to one or more anatomical structures located in an ocular or nasal region. The electrical stimulation may elicit a reflex that activates the lacrimal gland or may directly activate the lacrimal gland or nerves innervating the lacrimal gland to produce tears. The devices may be implantable or handheld, and may be configured to deliver the spatially and/or temporally patterned stimulation patterns described.