The present invention relates to an electric toothbrush that includes a head part and a handle part having a shape connectable to the head part and supplying a driving voltage to the head part according to a user's control. The head part may include a toothbrush head formed with a plurality of bristle holes where toothbrush bristles are disposed and a first through hole and a second through hole spaced apart from each other, a head body extending from the toothbrush head and having an inner passage connected to the first through hole and the second through hole, a head cover which closes the inner passage of the head body, and a first electrode rod and a second electrode rod inserted through the inner passage of the head body, whose one ends being positioned in the first through hole and the second through hole, respectively, and the other ends being exposed to the outside through the head cover, respectively.

Methods of lowering heart rate during physical activity for a user in need of an increase in their smallest concentric airway cross-sectional area include providing the person with a mandibular repositioning device having a maxillary tooth covering having a driver flange protruding laterally outward on a right and left side proximate a backmost teeth mold and a mandibular tooth covering having a protrusive flange extending cranially therefrom positioned to have a posterior side engaged with the anterior side of each driver flange. The anterior side of each driver flange has a convex curvature, and the posterior side of each protrusive flange has a concave-to-convex curvature from its base toward its most cranial point and a convex portion of the concave-to convex curvature engages the convex curvature of the driver flange in a rest position, and downward movement of the mandibular piece moves the user's mandible forward as well.

The present technology is generally directed to wearable devices for treating sleep apnea, and associated systems and methods. In some embodiments, a system for treating sleep apnea comprises an implantable device and a wearable device. The implantable device can be implantably positionable at a patient's head and/or neck, proximate to the patient's oral cavity, and include a signal generator configured to generate an electrical signal, an electrode coupled to the signal generator to direct the electrical signal to the patient's tissue, and a power receiver device coupled to the signal generator. The wearable device can include a power source and a power transmission device coupled to the power source and configured to transmit power wirelessly to the implantable device.

Neural stimulation is provided according to a closed loop algorithm to treat sleep disordered breathing (SOB), including obstructive sleep apnea (OSA). The closed loop algorithm is executed by a system comprising a processor (which can be within the neural stimulator). The closed loop algorithm includes monitoring physiological data (e.g., EMG data) recorded by a sensor implanted adjacent to an anterior lingual muscle; identifying a trigger within the physiological data, wherein the trigger is identified as a biomarker for a condition related to sleep (e.g., inspiration); and applying a rule-based classification (which can learn) to the trigger to determine whether one or more parameters of a stimulation should be altered based on the biomarker.

Systems and techniques for wireless implantable devices, for example implantable biomedical devices employed for biomodulation. Some embodiments include a biomodulation system including a non-implantable assembly including a source for wireless power transfer and a data communications system, an implantable assembly including a power management module configured to continuously generate one or more operating voltage for the implantable assembly using wireless power transfer from the non-implantable assembly, a control module operably connected to at least one communication channel and at least one stimulation output, the control module including a processor unit to process information sensed via the at least one communication channel and, upon determining a condition exists, to generate an output to trigger the generation of a stimulus.

Disclosed herein is an apparatus for facilitating application of varying pressure to a body of an individual, in accordance with some embodiments. Accordingly, the apparatus comprises pumps, actuators, and a valve. Further, the pumps are attached to the body using a coupling assembly. Further, the coupling assembly is configured to be attached to the body. Further, the coupling assembly comprises an interior cavity. Further, a first pump of the pumps is configured for drawing a first amount of air from the interior cavity. Further, a second pump of the pumps is configured for drawing a second amount of the air from the interior cavity and blowing a third amount of the air in the interior cavity. Further, the actuators are configured for actuating the pumps. Further, the valve is configured for allowing entering and exiting of an amount of the air from the interior cavity through the valve.

Described is a low voltage, pulsed electrical stimulation device for modulating expression of BMP9 protein(s) by cellular tissues.

Techniques for placing implantable electrodes to treat sleep apnea, and associated devices, systems, and methods are disclosed herein. A representative method includes percutaneously implanting one or more signal delivery devices, each at or near a respective target signal delivery location in a patient. Each signal delivery device can include one or more electrodes, and individual ones of the electrodes can be positioned to produce a net positive protrusive motor response of the patient's tongue. The representative method further includes providing power to one or more of the electrodes from a wearable power source to cause the electrode(s) to deliver an electrical signal to the respective target signal delivery location(s) to produce the net positive protrusive motor response.

Intraoral electrical stimulation devices are disclosed. A representative device, which can be used to treat sleep apnea, includes an intraoral attachment body, a guide element carried by the attachment body and having a constrained guide path, and an electrode movably supported relative to the guide element and movable along the constrained guide path to a plurality of positions. A positioning member is coupleable to the electrode to move the electrode along the constrained guide path, and a signal generator is coupleable to the electrode to direct a stimulation signal to the electrode.

An apparatus includes multiple first reservoirs and multiple second reservoirs joined with a substrate. Selected ones of the multiple first reservoirs include a reducing agent, and first reservoir surfaces of selected ones of the multiple first reservoirs are proximate to a first substrate surface. Selected ones of the multiple second reservoirs include an oxidizing agent, and second reservoir surfaces of selected ones of the multiple second reservoirs are proximate to the first substrate surface.