An implantable neurostimulator system including an electrical lead having formed thereon a pair of bipolar electrodes, the electrical lead is configured for placement of the pair of bipolar electrodes proximate protrusor muscles of a patient. The system also includes a pulse generator electrically connected to the electrical lead and configured to deliver electrical energy to the pair of bipolar electrodes, the pulse generator having mounted therein a sensor configured to detect one or more physiological parameters, a memory, a control circuit, and a telemetry circuit. The system also including a communications telemetry module (CTM) in communication with the telemetry circuit and configured to receive a data collected by the sensor and data related to delivery of electrical energy to the bipolar electrodes, and an external programmer in communication with the CTM and configured to display a user interface the data collected by the sensor and data related to delivery of electrical energy to the bipolar electrodes.

Provided is an oral care product comprising an effective amount of a soluble orally acceptable sulfate, e.g., sodium or potassium bisulfate, in a buffered, electrically conductive medium, which product is useful in a method for in situ production of per sulfate (S.sub.2O.sub.8.sup.2−), and methods of making and using the same, for example for whitening the teeth.

Devices for treating obstructive sleep apnea include appliances for securing to one or more teeth of a patient and connected to a lingual bridge configured to change shape and apply pressure to a patient's tongue, preventing backward movement of the tongue and blockage of the patient's airway. The lingual bridge is composed of a shape memory alloy to allow the bridge to change shape once deployed in a patient's oral cavity and exposed to increased temperature in the patient's mouth. Pulse generators and electrodes are included to electrically stimulate the nerves and muscles of the tongue to assist in keeping the tongue from moving backward in the mouth during sleep.

A mouthpiece for inhibiting breathing through a mouth of a user-wearer is disclosed herein. The mouthpiece for inhibiting breathing through a mouth of a user-wearer includes a blocking sheet, a relief port, and a flex recess. The blocking sheet may be made of a flexible material impermeable to air, and is configured to fit within the mouth of the user-wearer between the front teeth and the lips as well as the cheek area. The mouthpiece creates improved airflow for CPAP users by restricting airflow through the mouth.

An oral cleaning unit, e.g. a head for an oral cleaning and/or treatment device, includes electrodes for generating an RF field for providing an oral cleaning and/or treatment function. The unit includes at least a first and second protruding structure, which protrude in a same general direction away from a base or support structure. Each comprises one or more electrodes. The protruding structures are arranged facing one another and separated by a space or gap which is configured so as to be able to receive a tooth pushed or inserted therein between the first and second protruding structures, and with the protruding structures extending on either side of the tooth, i.e. straddling the tooth. This allows the RF electrodes comprised by the protruding structures to reach to a location at least part way down side faces of the tooth, closer to interproximal spaces, enabling interproximal spaces to be better cleaned, and optionally also to be sensed using RF energy/fields interacting with dental features, when the electrodes are suitably driven by an RF signal.

A device for increasing a concentration of at least one analyte in an advective flow of biofluid includes an agent for enhancing a paracellular permeability of an epithelial tissue; and an iontophoresis electrode and a counter electrode, which are adapted to increase the concentration of said analyte in the advective flow of the biofluid. A method of sensing an analyte in a biofluid includes increasing a paracellular permeability of an epithelial tissue layer; and inducing electro-osmotic flow by reverse iontophoresis to increase a concentration of said analyte in an advective flow of the biofluid, wherein said advective flow is driven by at least one of saliva generation, sweat generation, or reverse iontophoresis.

Systems and techniques for wireless implantable devices, for example implantable biomedical devices employed for biomodulation. Some embodiments include a biomodulation system including a non-implantable assembly including a source for wireless power transfer and a data communications system, an implantable assembly including a power management module configured to continuously generate one or more operating voltage for the implantable assembly using wireless power transfer from the non-implantable assembly, a control module operably connected to at least one communication channel and at least one stimulation output, the control module including a processor unit to process information sensed via the at least one communication channel and, upon determining a condition exists, to generate an output to trigger the generation of a stimulus.

A neuromodulation lead that is biased towards a substantially omega shape when fully deployed is provided. The neuromodulation lead includes a left set of electrodes disposed on a left portion of the lead body of the neuromodulation lead and a right set of electrodes disposed on a right portion of the lead body of the neuromodulation lead. The neuromodulation lead can be positioned in the plane between the genioglossus muscle and the geniohyoid muscle.

A method for delivery of oral iontophoretic or reverse-iontophoretic effect by electrical current in combination with electrokinetic elements (e.g., ions, charged molecule(s) (such as a medication or a bioactive agent), and/or charged molecular complexes that may include uncharged molecules), the electrical current causing a motive force on such elements to and from biological tissues and fluids.

A treatment device that shortens the time period until healing is determined even when a bone defect or a root apex lesion is generated in an apical area. The treatment device includes a file holder, a high-frequency signal generating circuit, and a control circuit. The file holder holds a file to be located in the site to be treated. The high-frequency signal generating circuit passes a high frequency current through the file. The control circuit controls a frequency of the high frequency current to be passed through the file from the high-frequency signal generating circuit. The control circuit controls the frequency of the high frequency current to be passed through the file within a range of 1.001 MHz to 11.700 MHz.