A heart support net in one aspect of the present disclosure includes a reception part configured to receive a heart and to be attached to an outer side of a ventricle. The reception part includes: a first conductive part; a second conductive part; and a non-conductive part. The first conductive part and the second conductive part are each knitted into mesh with a conductive yarn. The non-conductive part is knitted into mesh with a non-conductive yarn.

Representative embodiments of the present invention provide for novel, minimally invasive implantable devices and methods for targeted tissue drug delivery of cardiovascular drugs.

Various embodiments of a ventricular assist system and a method of using such system are disclosed. The system includes a pump adapted to be connected to a heart of a patient, an outflow cannula including a first end adapted to be connected to an outlet of the pump and a second end adapted to be connected to an artery of the patient, and an electrode disposed on an outer surface of the outflow cannula and adapted to be disposed adjacent to an exterior wall of the heart. The system further includes a controller electrically connected to the pump and the electrode, where the controller is adapted to provide a pacing signal to the electrode.

A process of treatment of internal organ oedema is using an electric current delivering electrode system comprising electrodes to be positioned at two places on the outer surface of the internal organ and/or in a liquid carrying vessel of the internal organ and delivering electric current to induce electro-osmosis between the electrodes. An electrode assembly system for this treatment by electro-osmosis includes, in addition to the two electrodes, a control unit adapted to control the current flow between the two electrodes.

A method for increasing left ventricular torsion by multi-point pacing includes fitting a plurality of pacemaker points at an epicardium of a heart such that the plurality of pacemaker points are positioned proximate an apex of a left ventricular muscle of the heart and sequentially pacing the plurality of pacemaker points. The left ventricular muscle of the heart twists in response to the sequential pacing. A system for implementing multi-point ventricular pacing is also provided.

Representative embodiments of the present invention provide for novel, minimally invasive implantable devices and methods for targeted tissue drug delivery of cardiovascular drugs.

Systems and methods for determining parameters and/or configurations for implantable pulse generator and/or lead(s) for the cardiac conduction system. The method includes configuring a stimulation vector. The method also includes configuring an AV delay to be less than an intrinsic AV delay, controlling a pulse generator to deliver pacing with a pacing amplitude, determining a sensing signal from artifacts of the pacing, adjusting the pacing amplitude based on the determined sensing signal and a capture signal, and determining the pacing threshold based on the adjusted pacing amplitude. The method further includes configuring the AV delay to a percentage of an intrinsic AV delay, controlling the pulse generator to deliver pacing with the AV delay, determining a sensing signal from artifacts of the pacing, adjusting the AV delay based on the determined sensing signal, and configuring the pulse generator with the adjusted AV delay.

Systems, methods, and devices to facilitate insertion of certain leads with electrode(s) into patients are described. Leads can be implanted to work in conjunction with a cardiac pacemaker or cardiac defibrillator. A lead for cardiac therapy may be inserted into an intercostal space associated with the cardiac notch of a patient. Devices for delivery may include, for example, a delivery system coupled with an electrical lead and having a handle, a component advancer and insertion tips. The handle is configured to be actuated by an operator and the component advancer is configured to advance an electrical lead into the patient. The insertion tips can be configured to close around the electrical lead within the component advancer, to push through biological tissue, and to open to enable the lead to advance into the patient. The electrical lead can also be maintained in a particular orientation during the advancement into the patient.

A core-shell nanowire, a method of forming the core-shell nanowire and a stretchable composite comprising the core-shell nanowire are provided. The core-shell nanowire comprises a core comprising a conductive metal and a shell comprising a biocompatible metal. The method of forming the core-shell nanowire comprises a step of forming a core-shell nanowire by carrying out epitaxial growth of a biocompatible metal on a surface of a core comprising a conductive metal. The stretchable composite comprises a first core-shell nanowire/polymer composite comprising first core-shell nanowires and a first polymer, a first insulating layer disposed on the first core-shell nanowire/polymer composite, and a second core-shell nanowire/polymer composite disposed on the first insulating layer and comprising second core-shell nanowires and a second polymer.

A cardiac net with at least one electrode enhances the pacing effect on a ventricle. The cardiac net with at least one electrode includes non-conductive portions formed by weaving non-conductive or conductive thread, defibrillation electrodes, and pacing electrodes, which are connected to one another. The defibrillation electrodes are configured to cover the circumference of the heart substantially horizontally, and are placed on an upper side and a lower side of the heart. The pacing electrodes are placed between the defibrillation electrodes and used for sensing the motions of the heart and pacing the ventricle. The pacing electrodes are configured to cover the circumference of the heart substantially horizontally so as to overlay the center of a spiral wave reentry. This configuration allows excitatory stimulus to be applied to the heart from the circumference thereof, thereby enabling the pacing electrodes to perform effective pacing.