This application is generally related to systems and methods for providing a medical therapy to a patient by tracking patient activity and adjusting medical therapy based on occurrence of different types of activities performed by the patient while automatically rescheduling stimulation programs based on detected patient activity.

The disclosure describes devices and methods for providing transdermal electrical stimulation therapy to a subject including positioning a stimulator electrode over a glabrous skin surface overlying a palm of the subject and delivering electrical stimulation via a pulse generator transdermally through the glabrous skin surface and to a target nerve or tissue within the hand to stimulate the target nerve or tissue within the hand so that pain felt by the subject is mitigated. The pulses generated during the electrical stimulation therapy may include pulses of two different magnitudes.

The present invention concerns an optoelectronic stimulating device for use in a medical treatment involving delivering an electrical current to an electrically excitable tissue (Z.sub.bio) by means of two electrodes (3n, 3p) electrically coupled to said tissue, said optoelectronic stimulating device comprising: (a) a source (4) of electrical impulses, which is electrically connected to (b) a source of light emission (2), in optical communication with (c) a photovoltaic cell (1) electrically connected to two electrodes (3n, 3p) for establishing two electrical contacts with said tissue and thus forming an electrical stimulating circuit fed by the photovoltaic cell (1) which is energized by the radiation of the source of light emission (2).

Systems and methods are described including a system for electrostimulation. The system includes a patch (22), including a plurality of electrodes (24a, 24b), and a mobile device (28). A processor (30) of the mobile device is configured to receive an input from a subject (20) that indicates that the subject is experiencing a headache, and, in response to the input, while the patch is coupled to the subject, wirelessly communicate a control signal that causes the electrodes to stimulate the subject. Other embodiments are also described.

Vagal nerve stimulation devices and methods are provided for treating medical conditions, such as conditions associated with insufficient dopamine and/or endogenous opioids in the brain. A device includes one or more electrodes having a contact surface for contacting an outer skin surface of a patient and an energy source coupled to the electrodes. The energy source generates one or more electrical impulses and transmits the electrical impulses to the electrodes and transcutaneously through the outer skin surface of the patient at or near a vagus nerve. The one or more electrical impulses is sufficient to modulate the vagus nerve and release dopamine and/or endogenous opioids in a brain of the patient.

An applicator can include a dispenser for dispensing an amount of a therapeutic composition, which can include an amount of sugar or sugar alcohol and an amount of an alkalizing agent. In some cases, the alkalizing agent can include L-Arginine. In some cases, 75% or more of the composition by weight has a comedogenicity rating of 3 or less on a scale of 0-5. The dispenser can also have a power supply configured to provide power through a contact tip of the dispenser to provide nerve stimulation, such as using vibration, heating, cooling, and/or electrical stimulation.

Systems and methods for producing physiological effects in response to simulated stimuli on living organisms are disclosed herein. In one example, a non-intrusive delivery of drug-simulating signals causes physiological effects on a living organism.

A neuromodulation system for treatment of physiological disorders. The system includes one or more stimulators for stimulating one or more cranial nerves; one or more detectors configured for detecting a predetermined physiological state; and a control unit that controls nerve stimulation by the one or more stimulators so that it is synchronized with the at least one predetermined physiological state detected by the one or more detectors. A method of neuromodulating a patient for treatment of physiological disorder. The method includes the steps of detecting a predetermined physiological state and applying stimulation to one of the cranial nerves during the predetermined physiological state by one or more stimulators of a neuromodulation system.

Respiratory sinus arrhythmia, or another bodily function that indicates a patient's parasympathetic tone, is used to control the delivery of vagal nerve stimulation to the patient for treating disorders that can be reflected and influenced by the behavior of the autonomic nervous system.

Provided herein are devices, systems, and methods for treating urological and gastrointestinal disorders, including bedwetting, through stimulation of the dorsal or plantar surface of the foot, including the superficial peroneal nerve and branches thereof, such as the dorsal intermediate and medial cutaneous nerves, or the medial and/or and lateral plantar nerves. The device facilitates placement of electrodes on the foot. Also provided herein is a system including the device, a pulse generator, and a controller, and methods of manufacturing and using the same.