A hermetically sealed feedthrough assembly for an active implantable medical device having an oxide-resistant electrical attachment for connection to an EMI filter, an EMI filter circuit board, an AIMD circuit board, or AIMD electronics. The oxide-resistant electrical attachment, including an oxide-resistant sputter layer 165 is disposed on the device side surface of the hermetic seal ferrule over which an ECA stripe is provided. The ECA stripe may comprise one of a thermal-setting electrically conductive adhesive, an electrically conductive polymer, an electrically conductive epoxy, an electrically conductive silicone, an electrically conductive polyimide, or a thermal-setting electrically conductive polyimide, such as those manufactured by Ablestick Corporation. The oxide-free electrical attachment between the ECA stripe and the filter or AIMD circuits may comprise one of gold, platinum, palladium, silver, iridium, rhenium, rhodium, tantalum, tungsten, niobium, zirconium, vanadium, and combinations or alloys thereof.

An implantable medical device (IMD) includes one or more stimulation engines (SEs) and selectively connectable output switching circuitry for driving a plurality of output nodes associated with a respective plurality of electrodes of the IMD's lead system when implanted in a patient. The output switching circuitry may be configured to facilitate self-test mode (STM) functionality in the IMD (e.g., when it is in a hermetically sealed package) by using a dual mode switch in series with a stimulation engine selection switch with respect to each output node in the output switching circuitry under mode selection control.

A peripheral nerve interface including a microclip having a substantial U-shape and including an upper entry portion for entry of a nerve into the microclip and a lower seating portion for seating the nerve in the lower seating portion of the microclip; a stretchable microelectrode array including a plurality of electrodes, wherein the stretchable microelectrode array has a proximal end portion fixed to the microclip and a portion that is moveable and dragged into the upper entry portion and then the lower entry portion of the microclip in response to the microclip be positioned on the nerve; and an interface connected to a distal end of the stretchable microelectrode array and configured to interface with an external device for applying electrical stimulation to the nerve seated in the lower seating portion and for recording electrical characteristic of the nerve seated in the lower seating portion via the plurality of electrodes in the stretchable microelectrode array.

We report a method of treating an epileptic seizure in a patient, comprising: detecting said epileptic seizure, based on body data from said patient; and reducing a flow of blood to a brain of said patient in response to said detected seizure; wherein said reducing is effected by: increasing the parasympathetic input to said patient's heart, such as by electrically stimulating a parasympathetic nervous structure, applying cooling energy to a sympathetic nervous structure, or administering a cholinergic or a sympatho-blocking agent to said patient. We also report a medical device system configured to implement the method. We also report a non-transitory computer readable program storage unit encoded with instructions that, when executed by a computer, perform the method.

Systems and techniques for wireless implantable devices, for example implantable biomedical devices employed for biomodulation. Some embodiments include a biomodulation system including a non-implantable assembly including a source for wireless power transfer and a data communications system, an implantable assembly including a power management module configured to continuously generate one or more operating voltage for the implantable assembly using wireless power transfer from the non-implantable assembly, a control module operably connected to at least one communication channel and at least one stimulation output, the control module including a processor unit to process information sensed via the at least one communication channel and, upon determining a condition exists, to generate an output to trigger the generation of a stimulus.

Disclosed are gastrointestinal dysfunction treatment protocols and kits for the testing, diagnosis, clinical intervention (diet, medications, temporary gastric electrical stimulation, and/or permanent gastric electrical stimulation), clinical feedback and/or associated treatment parameter adjustment for treating gastrointestinal dysfunctions in a patient. Embodiments of the present disclosure relate to how neuromodulation via gastric electrical stimulation, performed anywhere in the gastrointestinal (GI) tract, can help modulate inflammation and its resultant effects. Modulating inflammation via neuromodulation and gastric electrical stimulation enables treatment of a plurality of gastrointestinal dysfunctions.

A system for cardiac electrical stimulation treatment, comprising: an implantable pulse generator; one or more leads extending from the pulse generator to the heart for applying cardiac electrical stimulation; a controller programmed with at least one treatment plan for applying cardiac electrical stimulations, the controller configured to automatically update the treatment plan in response to actual cardiac activity by updating one or more parameters including: a time period during which cardiac electrical stimulations are applied; a rate of cardiac electrical stimulations; an amount of energy delivered at each cardiac electrical stimulation.

A gastric electric stimulation (GES) system is disclosed which includes a processing system, and at least one of a left vagus nerve sensor (L/R Sensors) and a right vagus nerve sensor coupled to the processing system, the processing system is configured to receive a model which statistically correlates sensed compound nerve action potential (CNAP) parameters measured from at least one of left and right vagus nerves of subjects within a population to feedback surveys of the subjects corresponding to a plurality of gastric symptoms and symptom parameters, receive one or more gastric symptoms of a subject outside of the population (Subject.sub.out), determine CNAP parameters that correspond to the gastric symptoms with least severity (CNAP.sub.min), measure CNAP activity of the Subject.sub.out from the L/R sensors while modifying GES parameters for the Subject.sub.out, select the GES parameters that corresponds to the CNAP.sub.min (GES.sub.out), and output the GES.sub.out.

Described herein are noninvasive electrical stimulation devices, systems and methods for stimulation of the Vagus nerve through its auricular branch to provide beneficial physiological responses in subjects, including alleviation, mitigation or elimination of symptoms of various disorders, including metabolic and inflammatory disorders.

Embodiments of the instant invention relate to applying motor learning to promote remyelination following demyelination in a subject having a condition or disease. In certain embodiments, applying motor learning alone or in combination with vagus nerve stimulation (VNS) induces the production of new and preserves surviving oligodendrocytes. In accordance with certain embodiments of the disclosure, motor learning, when properly timed, enhances oligodendrogenesis after injury and recruits mature oligodendrocytes to participate in remyelination through the generation of new myelin sheaths. In other aspects of the disclosure, VNS paired with motor learning enhances remyelination following demyelination.