This document discusses, among other things, systems and methods for managing pain of a subject. A system includes a first sensor circuit to sense a first signal indicative of a functional state of the subject, a second sensor circuit to sense a second signal different from the first signal, and a controller circuit. The controller circuit may determine an operating mode of the second sensor circuit according to the sensed first signal, trigger the second senor circuit to sense the second signal under the determined operating mode, and generate a pain score using at least the second signal sensed under the determined operating mode. The pain score may be output to a patient or used for closed-loop control of a pain therapy.

A method of treating an overactive bladder condition includes providing a stimulation device having a generator enclosing a primary cell that is coupled to circuitry, and a lead coupling an electrode assembly to the generator, where the circuitry is operable to generate a stimulation signal with a duty cycle of between 0.1% and 2.5% and a total average current drain from the primary cell of between 0.1 μA and 5 μA, with the total average current drain including a background current plus a stimulation current weighted by the duty cycle; forming an incision in skin of a patient diagnosed with the overactive bladder condition; implanting the stimulation device in the patient by inserting the stimulation device into the incision in the skin of the patient; and closing the incision.

A system for attachment of a device to a bone is provided. The system includes an internal axial rod with a proximal and distal end that is configured to be inserted and secured into a bone cavity's distal end. The system can also include an internal-external transfer rod with a proximal and distal end mounted into the distal end of the axial rod and a central channel extending through the transfer rod from the proximal end to the distal end and a plurality of attachment rings for attaching at least one tissue or muscle group to the transfer rod. The system also includes a bio-compatible and bio-occlusive artificial membranes (BIOCAMS) lamina, wherein the lamina includes either a polyetheretherketone (PEEK) mesh, a biocompatible polymer, a carbon fiber polymer, an artificial tissue polymer, molded donor tissue, allogenic tissue, a collagen/hyaluronic acid-based tissue, or connective tissue biosynthetic substrate material suitable as webbing.

A neuromodulation device is configured with a set of testing program configuration instructions including therapeutic neuromodulation field-setting parameters. The device determines a custom priming program in response to the testing program configuration instructions. The custom priming program controls the neuromodulation device to generate a priming field with specific correspondence to the therapeutic neuromodulation field to be produced by the testing program.

According to various embodiments, systems, devices and methods for modulating targeted nerve fibers (e.g., hepatic neuromodulation) or other tissue are provided. Systems, devices and methods for cooling energy delivery members are also provided. The systems may be configured to access tortuous anatomy of or adjacent hepatic vasculature. The systems may be configured to target nerves surrounding (e.g., within adventitia of or within perivascular space of) an artery or other blood vessel, such as the common hepatic artery.

A medical device system for delivering a neuromodulation therapy includes a delivery tool for deploying an implantable medical device at a neuromodulation therapy site. The implantable medical device includes a housing, an electronic circuit within the housing, and an electrical lead comprising a lead body extending between a proximal end coupled to the housing and a distal end extending away from the housing and at least one electrode carried by the lead body. The delivery tool includes a first cavity for receiving the housing and a second cavity for receiving the lead. The first cavity and the second cavity are in direct communication for receiving and deploying the housing and the lead coupled to the housing concomitantly as a single unit.

The disclosure describes example devices, systems, and techniques for delivering electrical stimulation to a patient. In some examples, an IMD includes a housing having a main portion and projection extending from the main portion. The projection of the housing may carry an electrode. Stimulation circuitry may be disposed within the main portion of the housing where the stimulation circuitry may generate electrical stimulation deliverable via the electrode. Processing circuitry may be disposed within the main portion of the housing where the processing circuitry may control the stimulation circuitry to generate the electrical stimulation.

Medical devices and methods for making and using the same are disclosed. An medical device may include a medical device for renal nerve ablation. The medical device may include a catheter shaft having a distal region. An expandable balloon may be coupled to the distal region. An electrode assembly may be coupled to the balloon. The electrode assembly may include a first electrode pad including one or more electrodes. The first electrode pad may have a first lead-in edge, a first protruding edge, and a first transition region with a continuously changing curvature disposed between the first lead-in edge and the first protruding edge.

Neural stimulator systems with an external magnetic coil to produce changing magnetic fields is applied outside the body, in conjunction with one or more tiny injectable objects that concentrates the induced electric or magnetic field to a highly-targeted location. These systems include a driver circuit for the magnetic coil that allows for high voltage and fast pulses in the coil, while requiring low-voltage power supply that may be powered by a wearable or portable external device, along with the coil and driver circuit.

The present disclosure relates to thin-film lead assemblies and neural interfaces with stent-assisted deployment, and methods of microfabricating thin-film lead assemblies and neural interfaces. Particularly, aspects of the present disclosure are directed to a medical device having a thin-film neural interface, a stent, and a cable. The thin-film neural interface includes a first supporting structure, electrodes formed on the first supporting structure, and an encapsulation material encasing a portion of the first supporting structure. The cable includes a second supporting structure, conducive traces formed on the second supporting structure and electrically connected with the electrodes, and the encapsulation material encasing at least a portion of the second supporting structure. The stent is at least partially embedded in the encapsulation material encasing the portion of the first supporting structure, and the thin-film neural interface is helically wrapped around at least a portion of the stent.