Methods for treating a subject for a parasympathetic bias mediated condition are provided. Aspects of the methods include modulating at least a portion of the subject's autonomic nervous system to increase the sympathetic/parasympathetic activity ratio in a manner effective to treat the subject for the parasympathetic bias mediated condition. In some instances, the subject is known to have parasympathetic bias. Also provided are devices that find use in practicing various embodiments of the methods.

Stimulation of neural activity in a nerve supplying the spleen, wherein the nerve is adjacent to the splenic artery at a position where the splenic artery is not in direct contact with the pancreas, can modulate pro- and anti-inflammatory molecules levels, thereby reducing inflammation and providing ways of treating disorders, such as disorders associated with inflammation. The invention provides improved ways of reducing inflammation with minimized off-target effects, in particular surgical trauma.

An implantable neurostimulator (INS) and method of use, the INS including an electrical lead having formed thereon at least a pair of bi-polar electrodes, wherein the electrical lead is configured for placement of the pair of bi-polar electrodes proximate protrusor muscles of a patient, a pulse generator electrically connected to the electrical lead and configured to deliver electrical energy to the pair of bi-polar electrodes, the pulse generator having mounted therein a sensor and a control circuit, and the sensor is configured to generate signals representative of an orientation of the pulse generator and communicate the signals to the control circuit and the control circuit is configured to determine the orientation of the pulse generator and deliver electrical energy to the bi-polar electrodes when the determined orientation correlates to a pre-determined orientation.

An implantable electrical stimulation device including an implant sized and configured to be implanted subcutaneously, the implant being configured to rectify a received pulse train of ultrasound into a single electrical pulse configured to stimulate a tibial nerve of a patient.

Devices, systems, and methods for pacing tissue are disclosed herein. In some embodiments, the devices, systems, and methods position a tip section of a catheter adjacent tissue within an anatomical structure. The tip section is attached to a distal end portion of a catheter shaft, has a maximum radial dimension that is larger than a maximum radial dimension of the catheter shaft, and includes a plurality of electrodes spatially distributed about the tip section. The devices, systems, and methods further select one or more groupings of individual ones of the plurality of electrodes and deliver stimulating energy to or through the adjacent tissue via the selected groupings of electrodes. The stimulating energy is sufficient to activate nerve tissue proximate the tip section but is insufficient to ablate the adjacent tissue. In this manner, devices, systems, and methods disclosed herein can be used to locate nerve tissue proximate the tip section.

An arrangement for reducing intraocular pressure includes a pulse signal source, a probe coupling, and at least one electrode. The probe coupling is configured to be supported on a portion of a living eye. The electrodes are supported on the probe coupling. The electrodes are operably coupled to receive a pulse signal from the pulse signal source.

The present disclosure relates to a method of generating visual percepts using conformal electrode arrays. The electrode arrays can be placed into the ventricular system or cerebral venous sinuses, which function as minimally invasive techniques for precise spatial and temporal localization of electrical activity within the brain, and precise electrical stimulation of brain tissue, to diagnose and restore function in conditions caused by abnormal electrical activity in the brain. The disclosure further comprises a system for using these arrays to generate time-varying electric fields to stimulate the visual pathways of the brain, including the optic radiations and the occipital cortex, in ways that lead to visual perception.

A method for screening a patient suffering from a urinary dysfunction for determining whether a patient is a viable candidate for therapy through the use of a neurostimulator. The neurostimulator is placed on the patient's skin and is operationally activated to transmit electrical or magnetic signals to a target nerve during therapy sessions held over an assessment time interval. During the therapy sessions, the patient provides therapeutic responses to the electrical or magnetic signals during the therapy sessions. Based upon the patient's therapeutic responses a determination is made to either implant the neurostimulator in the patient's body or to perform an alternative procedure.

There is provided a method of generating deep brain stimulation signals, the method comprising receiving a plurality of sensor signals from a corresponding plurality of sensors on or in a subject, and using the received sensor signals to generate a plurality of stimulation signals for application at a corresponding plurality of target sites in the brain of the subject. There is further provided a method of generating stimulation signals, the method comprising receiving a plurality of sensor signals from a corresponding plurality of sensors on or in a subject, and using the received sensor signals to generate a plurality of stimulation signals for application at a corresponding plurality of target sites on or in the subject using a model of the response of neurons in the subject to the stimulation signals that models neural tissue as a plurality of coupled populations of neurons.

Aspects of the present disclosure are directed to an implantable medical device including a housing containing components therein configured for delivering neurostimulation therapy, and an anchoring feature included with the housing. The implantable medical device also includes a lead having an electrode. In one aspect, the implantable medical device may include a guidewire passageway configured to allow the lead of implantable medical device to be introduced over a guidewire.