Systems, devices and methods are disclosed for the treatment of injured peripheral nerves or other tissue using electrical stimulation. The systems can be used either in intraoperative or peri-operative settings and incorporate the use of either a plurality of monopolar electrodes with a patch used as return or a plurality of bipolar electrodes such as a cuff. The systems can provide hands-free delivery of electrical stimulation therapy over a predetermined set of time.

Embodiments disclosed herein relate to systems and methods for detecting faults in leads and automatically reconfiguring a stimulation pattern of the leads based on a detected fault.

Apparatus, comprising (1) a first controller comprising at least one first-controller antenna configured to transmit a first wireless power signal having a first signal power; and a first-controller control unit configured to use battery power to drive the first-controller antenna; (2) a second controller, comprising at least one second-controller antenna, configured to transmit a second wireless power signal having a second signal power; and a second-controller control unit, configured to use mains electricity power to drive the second-controller antenna; and (3) an implant, comprising one or more electrodes; at least one implant antenna configured to receive 1-10 percent of the first signal power, and to receive 0.01-1 percent of the second signal power; and circuitry configured to drive the one or more electrodes responsively to the received 1-10 percent of the first signal power, or the received 0.01-1 percent of the second signal power.

A premodulated interferential current, particularly for spinal cord stimulation, is generated using a pulse generator having multiple electrodes. The premodulated current, which is delivered through at least one of the electrodes, includes a train of biphasic pulses having a repetition frequency, wherein each biphasic pulse includes a stimulating phase and a balancing phase. The premodulated current includes an amplitude modulation envelope having an envelope beat frequency smaller than the repetition frequency of the biphasic pulses, wherein the modulation envelope is generated in the pulse generator.

Electrical stimulation of a target (e.g., nervous tissue) is performed, wherein balance phases are automatically determined, and at least one of the electrodes is indirectly monitored during therapy delivery. The stimulation system is further configured to generate correction currents when a voltage accumulated at associated double layer capacitances crosses pre-defined thresholds so as to reduce or cancel the accumulated voltages without therapy interruption. A finer automatic determination of balance phases permits minimizing the stimulus artifact for evoked response sensing. Closed-loop neurostimulation may be performed based on such evoked responses.

A system, including: an implantable neural stimulator including electrodes, at least one antenna and an electrode interface; a radio-frequency (RF) pulse generator module comprising an antenna module configured to send an input signal to the antenna in the implantable neural stimulator through electrical radiative coupling, the input signal containing electrical energy and polarity assignment information that designates polarity assignments of the electrodes in the implantable neural stimulator; and wherein the implantable neural stimulator is configured to: control the electrode interface such that the electrodes have the polarity assignments designated by the polarity assignment information, create one or more electrical pulses suitable for modulation of neural tissue using the electrical energy contained in the input signal, and supply the electrical pulses to the electrodes through the electrode interface such that the electrodes apply the electrical pulses to the neural tissue with the polarity assignments designated by the polarity assignment information.

One aspect relates to a process for preparing a shaped metal product, wherein a monolithic metal precursor surrounded by a sacrificial outer element is formed to smaller dimensions, and the sacrificial material is subsequently removed. One aspect further provides a composite for preparing a shaped metal product, and a shaped metal product. Such shaped metal products can be used to manufacture an active implantable medical device or sensor.

Systems, devices and methods are disclosed for the treatment of injured peripheral nerves or other tissue using electrical stimulation. The systems can be used either in intraoperative or peri-operative settings and incorporate the use of either a plurality of monopolar electrodes with a patch used as return or a plurality of bipolar electrodes such as a cuff. The systems can provide hands-free delivery of electrical stimulation therapy over a predetermined set of time.

Techniques for sensing neural responses such as Evoked Compound Action Potentials (ECAPs) in an implantable stimulator device are disclosed. A first therapeutic pulse phase is followed by a charge recovery phase that includes at least one high-impedance passive charge recovery duration. The ECAP is sensed during the high-impedance passive charge recovery duration. The time period of the passive charge recovery is lengthened and the high-impedance passive recharge duration entirely overlaps the ECAP (i.e., the neural response duration) at the sensing electrode.

An implantable device has a hermetically sealed enclosure, an electronic device within the hermetically sealed enclosure, and a plurality of feedthrough conductors in mechanical contact with the hermetically sealed enclosure and exposed outside of the hermetically sealed enclosure. The implantable device also has a flexible substrate with a plurality of therapy contacts, and a plurality of continuously conductive elements extending along the flexible substrate from the array of therapy contacts and terminating at a plurality of connection pads. Each of the continuously conductive element is integral with at least one therapy contact and at least one connection pad to electrically communicate the noted therapy contact(s) and the noted connection pad(s). The thickness of each continuously conductive element may be between about 5 and 190 microns. The implantable device also has a plurality of mechanical welded couplings that each couple at least one of the connection pads.